Gambini is back! Hot on the heels of rescuing his cousin Bill and Bill's friend, Stan, from an Alabama electric chair, our wildly inappropriate hero, Vincent Gambini, heads home to Brooklyn, where he attempts to establish a successful law career. Meanwhile, Lisa aches to have a wedding band placed around her finger, and her biological clock is still ticking away like mad. Vinny and Lisa have been together 10 long years. She's waited so very patiently for him to complete law school and pass the bar. Winning his first case was the last piece of the puzzle, and now nothing can stand in the way of true love, except that between them they don't have two nickels to rub together, and Vinny is about as romantic as a box of frogs.

In the course of building his practice, Vinny is reunited with Joe, his walking, talking embarrassment of a brother; Lisa's nudging parents, Ma and Augie; and his dear old friend Judge Henry Molloy, who refers him the mother of all capital murder cases. Theresa Cototi is young and pretty but far from innocent, and darn her luck...her boyfriend has just been scraped off the pavement after taking a header from eight stories up. You'd better believe she's going to trial, charged with murder one.

Aided by Lisa and a ragtag team of misfits, Vinny defends his client against overwhelming odds. Our endearing neophyte attorney must match wits with a cunning DA and a formidable influence peddler who appears to anticipate his every move. In the balance hangs the life of a woman he believes to be innocent. Or is she? Yes, Vinny may have finally won his first case, but his and Lisa's story is far from over. Am I sure? Yeah! I'm pos-i-tive!