A new JAMA study examines the association between severe maternal morbidity in a first birth and the probability of a subsequent birth. Authors Neda Razaz, PhD, and Eleni Tsamantioti, MD, MMedSc, both from the Karolinska Institute in Sweden, discuss this and more with JAMA Associate Editor Melissa A. Simon, MD, MPH.

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• Association of Severe Maternal Morbidity With Subsequent Birth
• Severe Maternal Morbidity and Subsequent Birth—Understanding and Informing a Woman’s Choice

Elevated lipoprotein(a) levels increase the risk of atherosclerotic cardiovascular disease (ASCVD) and aortic stenosis. Cleveland Clinic’s Steven E. Nissen, MD, speaks with JAMA Executive Editor Gregory Curfman, MD, about how zerlasiran produced more than 80% reductions in time-averaged lipoprotein(a) concentration.

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• Zerlasiran—A Small-Interfering RNA Targeting Lipoprotein(a)

Preterm birth is the greatest cause of neonatal mortality and morbidity, with infants born extremely preterm at highest risk. Author Brett J. Manley, PhD, the Royal Women’s Hospital, Melbourne, Australia, discusses a new study of the effect of intratracheal corticosteroid administration on survival free of bronchopulmonary dysplasia in preterm infants, with JAMA Deputy Editor Tracy A. Lieu, MD, MPH.

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• Intratracheal Budesonide Mixed With Surfactant for Extremely Preterm Infants

Preventing obesity in early childhood is challenging for clinicians and families. Authors Eliana M. Perrin, MD, MPH, of Johns Hopkins University, and William J. Heerman, MD, MPH, of Vanderbilt University, join JAMA Deputy Editor Tracy Lieu, MD, to discuss "A Digital Health Behavior Intervention to Prevent Childhood Obesity: The Greenlight Plus Randomized Clinical Trial."

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• A Digital Health Behavior Intervention to Prevent Childhood Obesity

A new study published in JAMA found that drug-related supply chain issue reports were 40% less likely to result in meaningful drug shortages in Canada compared with the US. Authors Kate Suda, PharmD, MS, of University of Pittsburgh School of Medicine, and Mina Tadrous, PharmD, PhD, of University of Toronto, discuss this and more with JAMA Deputy Editor Joseph S. Ross, MD, MHS.

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• Differences in Drug Shortages in the US and Canada
• Understanding Drug Supply Shortages in the US and Canada

In the US, childbirth typically occurs in hospitals or accredited birth centers. President of the American College of Obstetricians and Gynecologists Stella Marie Dantas, MD, speaks with JAMA Deputy Editor Linda Brubaker, MD, MS, about newly proposed advanced birth centers that would permit higher-risk births, with concerns for patient safety and rural obstetric care access.

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• Advanced Birth Centers and the Effect on Maternity Care

The Declaration of Helsinki originated in 1964, developed by the World Medical Association (WMA). Process Chair Jack S. Resneck Jr, MD, discusses the 2024 updates to the Declaration of Helsinki with JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS.

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• Revisiting the Declaration of Helsinki—A Patient-Centered Perspective
• Future-Proofing Research Ethics—Key Revisions of the Declaration of Helsinki 2024
• The Revision of the Declaration of Helsinki Viewed From the Americas—Paving the Way to Better Research
• Declaration of Helsinki—Revisions for the 21st Century
• Facilitating Efficient and Ethical Trials at the Intersection of Research and Clinical Care
• The 2024 Revision to the Declaration of Helsinki

Transfusion strategy for patients with acute brain injury, telehealth care, acute kidney injury after cardiac surgery, and weaning ventilatory support are the topics of 4 trials published in JAMA and presented at the 2024 European Society of Intensive Care Medicine meeting. JAMA Associate Editor Christopher Seymour, MD, MSc, joins Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, to discuss.

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• Shifting Balance of the Risk-Benefit of Restrictive Transfusion Strategies in Neurocritically Ill Patients—Is Less Still More?
• Evaluating Complex Technological Innovations in Critical Care—Current Challenges and Future Directions
• Impact of Adsorptive Blood Purification on Kidney Outcomes
• Ventilator Weaning Strategies—Managing Interaction Between Randomized Treatments
• Restrictive vs Liberal Transfusion Strategy in Patients With Acute Brain Injury
• Effect of Tele-ICU on Clinical Outcomes of Critically Ill Patients
• Extracorporeal Blood Purification and Acute Kidney Injury in Cardiac Surgery
• Frequency of Screening and Spontaneous Breathing Trial Techniques