Janee lives with Ebstein's Anomaly, a rare congenital heart defect that has shaped every stage of her life. Diagnosed at birth and undergoing open-heart surgery at just seven years old, Janee shares the physical realities of living with arrhythmias, repeated hospital admissions, and the possibility of needing a heart transplant in the future. Yet throughout our conversation, what stands out most is not the medical complexity, but her remarkable resilience and positivity.

Janee reflects openly on growing up feeling different, hiding her surgical scar, and believing she had to keep her condition to herself. She explains how finding the congenital heart disease (CHD) community transformed her self-confidence, helping her realise she was not alone. That journey eventually inspired her to create The Heart Connection, a non-profit supporting adults living with congenital heart disease through practical care packages and a growing community of understanding.

This episode explores identity, belonging, fear, hope, and the extraordinary impact of finding people who truly understand your experience. Janee's warmth, honesty and determination shine throughout, making this an inspiring conversation about turning personal challenges into support for others.

The song that Janee chose is I Lived by OneRepublic.

This episode of On One Condition follows Jenny Trefzger’s journey through persistent abdominal and groin pain after surviving stage IV colon cancer.

After years of scans, colonoscopies, PET imaging, blood tests, spine evaluations, pain procedures, and repeated reassurances that cancer had not returned, Jenny eventually encountered the possibility of Anterior Cutaneous Nerve Entrapment Syndrome (ACNES), a frequently overlooked cause of chronic abdominal wall pain.

The conversation explores the emotional burden of living with a cancer history, the challenge of distinguishing new symptoms from recurrence anxiety, and the importance of hands-on examination, self-advocacy, and specialist expertise.

Despite a long and frustrating diagnostic journey, Jenny is optimistic that she has found the right team who will be able to treat her chronic pain.

The song that Jenny chose is At The Limit by Yuki Hayashi.

This episode is both about Carolina and her daughter Mariana’s journey with Pfeiffer Syndrome, and about how rare disease families can truly impact healthcare.

Carolina shares the long and emotionally exhausting path to diagnosis, the repeated hospitalizations and surgeries Mariana endured, and the emotional impact of raising a child with a visible rare disease.

What stands out throughout the conversation is Carolina’s extraordinary resilience and compassion. Rather than allowing fear and trauma to define their lives, she transformed her family’s experience into advocacy, education, and systemic change through the organizations she founded, including Born a Hero.

The episode explores difficult but important topics: medical gaslighting, delayed diagnosis, the emotional toll on caregivers, bullying, mental health, and the urgent need for patient-centred healthcare. Yet despite the challenges, the conversation is filled with hope, warmth, and humanity. Carolina repeatedly returns to the power of kindness, collaboration, community, and listening to patients and families.

It is ultimately a story about turning pain into purpose, and about how rare disease families often become the strongest advocates, educators, and changemakers.

The song that Carolina chose is The Truth by Megan Woods.