Epigenetics is the science of living DNA, charting the chemical pathways that spur DNA into action by turning genes on and off. While the Human Genome Project of the early 2000s was hailed as the key to understanding human heredity and disease, that historic effort was just the beginning. It has taken epigenetics to fill in the picture, explaining how the fixed code of our genome is implemented in countless living processes.

The promise of America is that the country is based on an idea, one where everyone is created equal and equally free to chart their own course. From 13 newly independent states ratifying a national constitution to the heated debates in the halls of Congress today, American politics is about negotiation over what our country is—and where we are going.

Thought experiments are “what if” scenarios that invite us to look carefully at how we think and view the world. They’ve been used throughout history by philosophers and other thinkers to explore our intuitions and ways of reasoning, to find solutions to problems, and to expand our knowledge of ourselves and the world. In these 24 eye-opening lectures, Professor Breyer takes you deeply into the historical tradition of thought experiments, shining a light on both the purpose and the outcomes of these compelling mental voyages.

Throughout the 24 lectures of Banned Books, Burned Books: Forbidden Literary Works, author and book critic Professor Maureen Corrigan of Georgetown University will take you on a tour of some of the most challenged and controversial works of literature, from the plays of Shakespeare to 21st-century best-sellers—even including the dictionary and classic fairy tales. You will trace the history, in the United States and Great Britain, of the challenges to books, the censoring of books, book bans, and even burnings.

The issues addressed by macroeconomics are all around you, all the time—from taxes to inflation to mention of the GDP on the nightly news. By learning the principles of macroeconomics, you’ll be able to go beyond simply hearing the terms to better understanding their relationships to each other and how they create the economic environment in which you live. In fact, macroeconomics with its “big-picture glasses” allows you to better ask—and better try to answer—the biggest questions of our time, questions that impact the lives of billions of people.

Railways are one of the most important inventions in modern history. From the 1825 opening of the Stockton and Darlington Railway in England, trains revolutionized both travel and trade and radically changed the way we experience the world. In the 24 richly illustrated lectures of How Railways Transformed the World, you’ll experience the amazing world and impact of railways, from the early 19th century to today’s futuristic trains, including extensive material on the pleasure and appeal of rail travel today.

The Middle Ages was a time of major historical shifts and transformations. This amazing era reverberates with discoveries, innovations, events, and historical processes that are integral to the world we know now. In these 24 enthralling lectures, Professor Salisbury leads you on a sumptuous tour of this incredible historical epoch, making clear that the remarkable historical currents and advances of the Middle Ages unfolded not only in the West, but across the globe, from Europe, Africa, and the Middle East to Asia, the Americas, and beyond.

Sales is not about being pushy, aggressive, or unethical. In fact, you might be surprised to learn that “sales” is about nurturing, solving problems, helping, and building relationships. When you learn the right strategies to sell something, you’ll make your own life better because we are all constantly selling—whether it’s getting a promotion, working on a team project, or even just selecting the restaurant of your choice with friends.

In London in the Time of Dickens, you’ll get the unique opportunity to experience the British capital through the eyes of a literary master whose work is inextricably tied to the city and its rich history. Throughout 12 lectures taught by Professor Lillian Nayder of Bates College, you’ll tour the city of London in a time of rapid transformation through the life and work of Charles Dickens, uncovering the history of the metropolis, while also witnessing the everyday experiences of Londoners from all walks of life as Dickens represents them.

In Understanding Cognitive Biases, you will learn how to recognize biases for what they are, counteract them when necessary, and even use them to your advantage in some instances. In 24 fascinating lectures, Dr. Alexander B. Swan uses examples from psychology experiments, history, politics, movies, TV, comics, social media, and more to illustrate dozens of cognitive biases that affect us all.

Imagine a Museum of Lost Art. If this imaginary museum contained just the artwork we knew was lost— whether from theft, purposeful destruction, vandalism, war, or the forces of nature—it would still contain more masterpieces than those in all the world’s current museums combined. Imagine that! In Lost Art: The Stories of Missing Masterpieces, art historian Noah Charney guides you through just such an imaginary museum. In 12 fascinating lectures, you will hear the stories behind the theft and/or destruction of some of the world’s most famous pieces of art.

10 interview-based episodes that take ancient designs and applies them to modern lives. Your expert is Prince EA, an artist and inspirational speaker who’s spent the greater part of his career thinking about the ancient world.

In 20 captivating lectures, Professor Suzanne Pilaar Birch shares her expertise and passion for discovery as she peels back the years to expose the emergence and lives of early humans. You will learn about their environmental challenges, the methods they used to meet their basic needs, cultural development, and the fascinating advances in our own technologies that have allowed us to take their few physical remains and develop a much fuller picture.

To examine the connection between the storytelling impulse and our implicit desire to understand our lives and our place in the world, you will go on a globe-spanning, time-travelling, media-traversing tour in the 12 lectures of Storytelling and the Human Condition. Your guide is award-winning journalist, author, and storyteller Alexandra Hudson, founder of Civic Renaissance, a community of lifelong learners, which she invites you to join at Civic-Renaissance.com. In this course, she will illuminate the many ways stories shape our lives throughout history and across cultures.

Think of Cultured: A World History of Cheese as a 10-episode cheese course, or a cheese plate large enough to contain a well-rounded sampling of great cheeses from around the world. Janet Fletcher, a noted food writer and publisher of the Planet Cheese blog, provides deeper (and delectable) insights into a familiar food you only think you know. Included in this Audible Original are peeks at the nine steps of cheesemaking, the 10 most important cheese families, and tips on how to taste cheese with the same refined palate as a professional cheese judge.

The brain is a marvelous and complex organ that takes decades to fully mature, and no stage in that long process is more critical than the one we call the “toddler” years. During this period—from about one year old to three years old—a child transforms from a helpless infant into a running, chatting, insatiably curious little person with distinctive traits and interests. So, what is happening in the brain during this metamorphosis? How do humans acquire the motor, linguistic, and social skills that define this vital childhood period? Lise Eliot offers answers to these intriguing questions.

Mescaline, LSD, and psilocybin mushrooms. There’s been a lot of discussion in the medical world lately about the potential benefits of these and other drugs for certain medical conditions, such as anxiety and depression. As we consider the place of psychedelics in the future, we can draw insight and guidance from the history of how psychedelics have been described, sought after, applied, and prohibited over the centuries. Erika Dyck, professor of history at the University of Saskatchewan, introduces you to the world of hallucinogens.

Why are we scared of ghosts, zombies, vampires, demons, and monsters, when we know they are not real? Why do dark attics give us the creeps? How do writers and directors know exactly what anxieties to tap into, so that we break out in goosebumps, cover our eyes, and cringe? Shannon Scott invites you into the spooky, creepy, and sometimes surprising world of the horror genre to examine how popular scary movies and books manipulate our collective and individual fears—not only to frighten us, but also to address taboo subjects, and to reflect and comment on the state of our society.

From spirituality to politics and science, the occult has had an astonishing influence on the human experience across the centuries. It may surprise you to learn that everyday activities like attending church services or reading your daily horoscope all fit the broad definition of the occult. As you will see in the 24 illuminating episodes of Secrets of the Occult, the mystic and obscure are threaded through our ordinary lives in more ways than you may realize.

After Romeo and Juliet, Elizabeth Bennet and Fitzwilliam Darcy might just be the world’s most famous fictional couple. The story of how they fall in love—Pride and Prejudice—has left an indelible imprint on popular culture. Readers, novelists, playwrights, filmmakers, and even zombies can’t leave Pride and Prejudice alone. Which raises the question: Why has this novel, of all Jane Austen’s works, remained the general favorite?

The glorious repertoire for solo piano includes many of classical music’s most beloved masterpieces. In these 24 musically rich lectures, you’ll dig deeply into this magnificent tradition, in an in-depth exploration of the art of listening. With Professor Kautsky’s inspired guidance and expert playing, you’ll highlight key works of each composer, and unpack their structure, the musical materials that drive them, and the specific features that affect listeners so strongly, giving you a clear grounding in how to approach and hear this great music.

Sleep neurologist Jennifer Molano explores many different aspects of sleep, helping you better understand common sleep issues and providing practical tips to improve sleep in your life. Over the course of six lectures, she will reveal what drives our sleep-wake cycle, what “healthy sleep” is, how our sleep cycles change over time, why sleep is important in regulating systems in our brains and bodies, and what symptoms may occur with sleep disturbances.

Though it ended five centuries ago, the medieval era continues to permeate our world in far-reaching ways. Whether we pay attention to them or not, the influences and imprints of the Middle Ages are all around us, sometimes evident and sometimes less so. In these 36 revealing lectures, you’ll learn how to recognize the medieval impacts on the modern world, and to grasp their significance and implications. The Medieval Legacy offers you a deep look at a stunning millennium of change and innovation which continues to inform our contemporary world.

Heidi Sormaz has a PhD in psychology from Yale University with an emphasis on cognitive psychology, and she’s been a meditation and yoga practitioner and teacher for two decades. She is also a reformed over-thinker, so, she knows exactly what you’re going through—or what you’re (over)thinking, so to speak. Over the 12 engaging lessons of Overcome Your Overthinking, Heidi not only provides the science behind cognitive behavioral therapy but she’ll also arm you with a toolbox of exercises and techniques that are most effective at breaking the spell of overthinking.

England: From the Fall of Rome to the Norman Conquest takes you through the mists of time to the rugged landscape of the British Isles. Over the course of 24 sweeping lectures, Professor Jennifer Paxton of The Catholic University of America surveys the forging of a great nation from a series of warring kingdoms and migrating peoples. From Germanic tribes to Viking invasions to Irish missionaries, she brings to life an underexamined time and place.