When the Dickenson clan sits down for Thanksgiving dinner in 2016, it is the last holiday where their tight-knit family will ever be the same. Oldest brother Pete and his wife are expecting their first child. Youngest sibling Sophie is too busy running her restaurant. The Little Plum, to bother with any kind of social life. And middle child Charlie’s happy, uncomplicated life as a midwestern science professor is upended when his wife Annette is diagnosed with a terminal illness. Knowing this will be her last Thanksgiving, Annette asks Sophie to look after Charlie after she’s gone.

As one of the most popular influencers on social media, Mia Bell has lived her life online for years. With her celebrity dog and gorgeous fiancé, she is planning the ultimate virtual wedding - expensive, elaborate, and entirely paid for by sponsors. But off-camera, her world is far from picture perfect. After being jilted by her fiancé and faking her nuptials to please her sponsors, Mia finally has had enough. She heaves her phone off a cliff, ready to live - and maybe find love - offline for a change.

Overworked and underappreciated, single mom Amy Byler needs a break. So when the guilt-ridden husband who abandoned her shows up and offers to take care of their kids for the summer, she accepts his offer and escapes rural Pennsylvania for New York City. Usually grounded and mild mannered, Amy finally lets her hair down in the city that never sleeps. She discovers a life filled with culture, sophistication, and - with a little encouragement from her friends - a few blind dates.

Celeste Mason is the Pinterest stay-at-home supermom of other mothers’ nightmares. Despite her all-organic, SunButter-loving, free-range kids, her immaculate home, and her volunteering awards, she still has time to relax with a nice glass of pinot at the end of the day. The only thing that ruins it all is her workaholic, career-obsessed neighbor, who makes no secret of what she thinks of Celeste’s life choices every chance she gets.

Alexis Spencer thinks she has it all figured out. Even when life gets her down, she’s never too far away from another inspirational quote to rationalize her failures and ignore all her problems. Her boyfriend breaks it off, she loses her job, her closest friends are a distant memory, and her college debt is still as high as the day she left. In typical fashion, she blames the world for her problems, including her 18-year-old self who should have just tried harder and put their life on a better track.