What if the biggest risk factor for cancer, heart disease, and dementia isn't your genes, diet, or blood pressure but aging itself? Listen in as biogerontologist Dr. Matt Kaeberlein reveals how understanding the biology of aging could add not just years to our lives, but healthy decades, and why your dog might hold some of the most important clues.

In this episode, Therese Markow and Dr. Matt Kaeberlein discuss aging research. He explains that aging is characterized by damage accumulation and loss of resilience, leading to functional decline. Matt highlights the hallmarks of aging, such as deregulation of nutrient sensing and DNA damage, and the potential of interventions like rapamycin to slow aging. He notes that biological age is a significant risk factor for major diseases, and that understanding and addressing aging biology could significantly extend human lifespan. They also discuss the Dog Aging Project, with 55,000 participating dogs, which aims to uncover genetic and environmental factors influencing health and longevity in pets.

Key Takeaways:

• Our bodies are constantly being exposed to stress, and stress can move us out of the optimal zone of function. When we're young, we're very resilient and able to come back to optimal function. As we get older, we lose that resilience.

• When we slow aging in laboratory animals, we prevent the onset and progression of all of the major age-related functional declines and diseases simultaneously, because we've slowed biological aging. Based on what's possible in mice, it is estimated that we could potentially gain 2-3 additional decades of life if we can achieve this in humans.

• There is a genetic component to longevity; however, how big that genetic component is to longevity is hotly debated. The environment is also a large contributor.

"Biological age is the single greatest risk factor for nine of the top 10 killers in the United States, and it's not a small effect. The magnitude of effect from biological aging dwarfs all of the other risk factors combined…it's useful to appreciate how important biological age is to the risk of developing many of the chronic diseases and functional declines that limit quality and quantity of life for most people." — Dr. Matt Kaeberlein

Episode References:

• Dog Aging Project: https://dogagingproject.org/

• Dog Aging Institute: https://dogaginginstitute.org/

• Longevity for Dogs: https://www.youtube.com/@LongevityForDogs

Connect with Dr. Matt Kaeberlein:

Professional Bio: https://halo.dlmp.uw.edu/people/matt-kaeberlein/

Publications: https://pubmed.ncbi.nlm.nih.gov/?term=%22kaeberlein+m%22[author]

YouTube: https://www.youtube.com/@mkaeberlein

LinkedIn: https://www.linkedin.com/in/mkaeberlein/

Connect with Therese:

Website: www.criticallyspeaking.net

Bluesky: @CriticallySpeaking.bsky.social

Instagram: @criticallyspeakingpodcast

Email: theresemarkow@criticallyspeaking.net

Audio production by Turnkey Podcast Productions. You're the expert. Your podcast will prove it.

In this episode, Therese Markow and psychologist Dr. Elizabeth Scott discuss narcissism, its clinical definition, and the characteristics of "malignant narcissism". Dr. Scott explains that narcissism involves patterns of grandiosity, a need for constant admiration, a lack of empathy, high levels of manipulation, and the narcissist's "kryptonite" - criticism. They view themselves as the victim, never at fault. Despite their arrogance, they are very insecure. Dr. Scott also discusses why treatment is challenging and why therapy often focuses on managing symptoms rather than the deeper core issues. They can't see that they have a problem, and thus are resistant to treatment.

Key Takeaways:

• The myth of Narcissus illustrates the danger of excessive self-focus, which is the hallmark of narcissism in clinical terms and is becoming increasingly common in some aspects of our modern society.

• Narcissists are very good at manipulation. They consciously will do things to sort of manage their image in the eyes of others. They may appear to show empathy at times in a relationship, but it's usually more of a means to an end than a genuine concern for the feelings of others.

• Criticism is like kryptonite to a narcissist, so even the mildest critique can provoke a strong defensive reaction: anger, denial, or shifting the blame to somebody else.

• You cannot change a narcissist's behavior, but you can control your own responses to it. Think about limits and then give yourself leeway within those to protect your own mental health.

"[Narcissists] might mimic empathetic behaviors to achieve their own ends, but it's more about manipulation than genuine caring. So they can understand maybe what empathy looks like, but not really get how it feels and how it's supposed to feel and how those behaviors are supposed to be rooted in something inside them." — Elizabeth Scott, Ph.D.

Connect with Elizabeth Scott, Ph.D.:

Twitter: https://x.com/ElizabethScott

Facebook: https://www.facebook.com/AboutStressManagement/

Website: https://drelizabethscott.com/

Instagram: https://www.instagram.com/dr.elizabethscott/

Book: 8 Keys to Stress Management: https://www.amazon.com/Keys-Stress-Management-Mental-Health-ebook/dp/B00AJUKO5M

Connect with Therese:

Website: www.criticallyspeaking.net

Bluesky: @CriticallySpeaking.bsky.social

Instagram: @criticallyspeakingpodcast

Email: theresemarkow@criticallyspeaking.net

Audio production by Turnkey Podcast Productions. You're the expert. Your podcast will prove it.

Do you ever feel exhausted by home life, even when the chores look "even"? This episode uncovers the hidden mental load running beneath every household and reveals how it quietly shapes stress, careers, and relationships.

Today, Therese Markow and Dr. Allison Daminger discuss her research on cognitive labor, which reveals gender inequality in household decision-making. Allison interviewed 92 couples, and they discuss the results found between both queer and heterosexual couples throughout the study. These decisions were categorized into 10 domains, ranging from maintenance to health to childcare. Throughout the episode, Allison emphasizes the need for couples to recognize and address the imbalances, suggesting starting with low-hanging fruit and fostering a growth mindset to achieve a more equitable division of labor.

Key Takeaways:

• In different-sex households, cognitive labor is overwhelmingly shouldered by women, with roughly 80% of such homes being woman-led across domains like schedules, childcare coordination, finances, and home maintenance.

• Same-sex couples tend to divide cognitive labor more deliberately and flexibly, often discussing who does what and viewing roles as changeable rather than fixed by gender stereotypes.

• Unequal cognitive labor carries real costs - chronic exhaustion, career compromises, and relationship strain - making it crucial for couples to name this work, question "it just happened this way" narratives, and experiment with small, intentional rebalances in specific domains.

• Women's lives changed dramatically in the second half of the twentieth century, in a way that men's lives did not. However, there is now an emerging trend that seems to show more men feeling a pull toward the traditional household cognitive load often carried by women.

"One reason that my research has resonated with a lot of people is that it's given them language to explain something that they experience every day. People know that they're doing a lot, but until they recognize this as a form of work that is taxing, it can be easy to kind of downplay what you're contributing to your family, especially when it feels like you and your partner are sharing the physical work relatively equitably." — Dr. Allison Daminger

Connect with Allison:

Professional Bio: https://www.allisondaminger.com/about

Substack: https://allisondaminger.substack.com/

Website: https://www.allisondaminger.com/

LinkedIn: https://www.linkedin.com/in/allisondaminger

Book: What's On Her Mind: The Mental Workload of Family Life - https://bookshop.org/p/books/what-s-on-her-mind-the-mental-workload-of-family-life-allison-daminger/585e2aa7eac0a0ea

Connect with Therese:

Website: www.criticallyspeaking.net

Bluesky: @CriticallySpeaking.bsky.social

Instagram: @criticallyspeakingpodcast

Email: theresemarkow@criticallyspeaking.net

Audio production by Turnkey Podcast Productions. You're the expert. Your podcast will prove it.