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  • Leucovorin for Autism Spectrum Disorder: Is There Any Evidence Behind the Hype? - Frankly Speaking Ep 501

    Leucovorin for Autism Spectrum Disorder: Is There Any Evidence Behind the Hype? - Frankly Speaking Ep 501
    2026/09/07

    Credits: 0.25 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-501

    Overview: Leucovorin has gained growing attention as a treatment for autism spectrum disorder (ASD), despite limited supporting evidence. In this episode, we discuss the rationale behind its use, review the current literature, and examine the American Academy of Pediatrics’ guidance on this treatment for ASD, giving you confidence to counsel families and engage in meaningful shared decision-making.

    Episode resource links:

    • Discuss the rationale for using leucovorin in treatment of autism spectrum disorder (ASD)
    • Review current evidence and practice guidelines regarding leucovorin and ASD
    • Examine data and recent national trends in prescription rates of leucovorin for ASD

    Guest: Anne Powell, MD Music Credit: Matthew Bugos

    Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com

    The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.
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    12 分
  • 500th Episode: Hot Topics, Then and Now - Frankly Speaking Ep 500 (Audio Only)

    500th Episode: Hot Topics, Then and Now - Frankly Speaking Ep 500 (Audio Only)
    2026/09/03
    Credits: 0.75 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-500 Overview: To celebrate our 500th episode, each member of our team revisits a popular topic from the podcast’s earlier installments—GLP-1s, cervical and breast cancer screening, diet and exercise, contraception, hypertension, and lipid management—to trace how the evidence and guidelines have changed since it was first covered. Whether you’re catching up or reinforcing what you know, this milestone episode helps you bring the latest evidence into everyday patient care. Guest: Robert Baldor, MD, Alan Ehrlich, MD, Susan Feeney, DNP, FNP-BC; FAANP, Jillian Joseph, PA, Mariyan L. Montaque, DNP, FNP-BC, Jill Terrien PhD, ANP-BC, FAAN Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com Episode resource links: Zhou H et al. Evaluation and Comparison of the PREVENT and Pooled Cohort Equations for 10‐Year Atherosclerotic Cardiovascular Risk Prediction. Journal of the American Heart Association Volume 14, Number 4Goff DC et al. 2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association task force on practice guidelines. Circulation. 2014;129:S49–S73.Circulation. 2018 Jul 24;138(4):345-355. eClinicalMedicine 2025: 103741.Curry, J. (2018). Screening for cervical cancer: US Preventive Services Task Force Recommendation Statement. JAMA.320(7):674-686. doi:10.1001/jama.2018.10897 https://www.ncbi.nlm.nih.gov/pubmed/30140884 Perkins RB, Wolf AMD, Church TR, et al. Self-collected vaginal specimens for human papillomavirus testing and guidance on screening exit: An update to the American Cancer Society cervical cancer screening guideline. CA Cancer J Clin. 2026;e70041. doi:10.3322/caac.70041 Screening for Cervical Cancer (2026). Obstetrics & Gynecology, 148(1), e63-e67. https://doi.org/10.1097/AOG.0000000000006257 Jad Zeitouni, Nosayaba Osazuwa-Peters, Yusuf Dundar, Gregory Zimet, Mark A. Varvares. (2025). Two decades of the HPV vaccine: its promise, progress, prospects, projections, and posterity, The Lancet Regional Health - Americas, (51), https://doi.org/10.1016/j.lana.2025.101243Diabetes, Obesity and Metabolism 28, no. 6 (2026): 5043–5057, https://doi.org/10.1111/dom.70698. Relationship of early rapid weight loss to efficacy and safety of tirzepatide and semaglutide for obesity: SURMOUNT-5 post hoc analysis. Am J Med. 2026 Jul;139(7):913-921. doi: 10.1016/j.amjmed.2026.03.010US Preventive Services Task Force; Nicholson WK, Silverstein M, Wong JB, et al. Screening for breast cancer: US Preventive Services Task Force recommendation statement. JAMA. 2024;331(22):1918–1930. Trentham-Dietz A, Chapman CH, Jayasekera J, et al. Collaborative modeling to compare different breast cancer screening strategies: a decision analysis for the US Preventive Services Task Force. JAMA. 2024;331(22):1931–1946.Giaquinto AN, Sung H, Miller KD, et al. Breast cancer statistics, 2022. CA Cancer J Clin. 2022;72(6):524–541. Qaseem A, Harrod CS, Balk EM, et al. Screening for breast cancer in asymptomatic, average-risk adult females: a guidance statement from the American College of Physicians (Version 2). Ann Intern Med. 2026.: American Cancer Society. Breast Cancer Facts & Figures 2022–2024. Atlanta, GA: American Cancer Society, 2022. Hu X, Chehal PK, Kaplan C, et al. Racial differences in patient-reported symptoms and adherence to adjuvant endocrine therapy among women with early-stage, hormone receptor-positive breast cancer. JAMA Netw Open. 2022;5(8):e2225485. Torres JM, Sodipo MO, Hopkins MF, Chandler PD, Warner ET. Racial differences in breast cancer survival between Black and White women according to tumor subtype: a systematic review and meta-analysis. J Clin Oncol. 2024;42(35):4225–4234. Bailey ZD, Krieger N, Agénor M, Graves J, Linos N, Bassett MT. Structural racism and health inequities in the USA: evidence and interventions. Lancet. 2017;389(10077):1453–1463.Hypertension. 2026;83:00–00. DOI: 10.1161/HYPERTENSIONAHA.125.25787Allen RH, Bartz D. Opill: The Over-the-Counter Contraceptive Pill. Obstet Gynecol. 2024;143(2):184-188. doi:10.1097/AOG.0000000000005455 Cahill EP, Kaur S. Advances in contraception research and development. Curr Opin Obstet Gynecol. 2020;32(6):393-398. doi:10.1097/GCO.0000000000000666 Charles DN, Nagarsheth M, Oshman L. Pain Management for IUD Insertion in Primary Care. Am Fam Physician. 2025;111(4):299-301. Chen, C., Strasser, J., Banawa, R., Luo, Q., Bodas, M., Castruccio-Prince, C., Das, K., & Pittman, P. (2022). Who is providing contraception care in the United States? An observational study of the contraception workforce. American journal of obstetrics and gynecology, 226(2), 232.e1–232.e11. https://doi.org/10.1016/j.ajog.2021.08.015 Diedrich,J., Klein, D. Peipert, J...
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    41 分
  • 500th Episode: Hot Topics, Then and Now - Frankly Speaking Ep 500

    500th Episode: Hot Topics, Then and Now - Frankly Speaking Ep 500
    2026/08/31
    Credits: 0.75 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-500 Overview: To celebrate our 500th episode, each member of our team revisits a popular topic from the podcast’s earlier installments—GLP-1s, cervical and breast cancer screening, diet and exercise, contraception, hypertension, and lipid management—to trace how the evidence and guidelines have changed since it was first covered. Whether you’re catching up or reinforcing what you know, this milestone episode helps you bring the latest evidence into everyday patient care. Guest: Robert Baldor, MD, Alan Ehrlich, MD, Susan Feeney, DNP, FNP-BC; FAANP, Jillian Joseph, PA, Mariyan L. Montaque, DNP, FNP-BC, Jill Terrien PhD, ANP-BC, FAAN Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com Episode resource links: Zhou H et al. Evaluation and Comparison of the PREVENT and Pooled Cohort Equations for 10‐Year Atherosclerotic Cardiovascular Risk Prediction. Journal of the American Heart Association Volume 14, Number 4Goff DC et al. 2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association task force on practice guidelines. Circulation. 2014;129:S49–S73.Circulation. 2018 Jul 24;138(4):345-355. eClinicalMedicine 2025: 103741.Curry, J. (2018). Screening for cervical cancer: US Preventive Services Task Force Recommendation Statement. JAMA.320(7):674-686. doi:10.1001/jama.2018.10897 https://www.ncbi.nlm.nih.gov/pubmed/30140884 Perkins RB, Wolf AMD, Church TR, et al. Self-collected vaginal specimens for human papillomavirus testing and guidance on screening exit: An update to the American Cancer Society cervical cancer screening guideline. CA Cancer J Clin. 2026;e70041. doi:10.3322/caac.70041 Screening for Cervical Cancer (2026). Obstetrics & Gynecology, 148(1), e63-e67. https://doi.org/10.1097/AOG.0000000000006257 Jad Zeitouni, Nosayaba Osazuwa-Peters, Yusuf Dundar, Gregory Zimet, Mark A. Varvares. (2025). Two decades of the HPV vaccine: its promise, progress, prospects, projections, and posterity, The Lancet Regional Health - Americas, (51), https://doi.org/10.1016/j.lana.2025.101243Diabetes, Obesity and Metabolism 28, no. 6 (2026): 5043–5057, https://doi.org/10.1111/dom.70698. Relationship of early rapid weight loss to efficacy and safety of tirzepatide and semaglutide for obesity: SURMOUNT-5 post hoc analysis. Am J Med. 2026 Jul;139(7):913-921. doi: 10.1016/j.amjmed.2026.03.010US Preventive Services Task Force; Nicholson WK, Silverstein M, Wong JB, et al. Screening for breast cancer: US Preventive Services Task Force recommendation statement. JAMA. 2024;331(22):1918–1930. Trentham-Dietz A, Chapman CH, Jayasekera J, et al. Collaborative modeling to compare different breast cancer screening strategies: a decision analysis for the US Preventive Services Task Force. JAMA. 2024;331(22):1931–1946.Giaquinto AN, Sung H, Miller KD, et al. Breast cancer statistics, 2022. CA Cancer J Clin. 2022;72(6):524–541. Qaseem A, Harrod CS, Balk EM, et al. Screening for breast cancer in asymptomatic, average-risk adult females: a guidance statement from the American College of Physicians (Version 2). Ann Intern Med. 2026.: American Cancer Society. Breast Cancer Facts & Figures 2022–2024. Atlanta, GA: American Cancer Society, 2022. Hu X, Chehal PK, Kaplan C, et al. Racial differences in patient-reported symptoms and adherence to adjuvant endocrine therapy among women with early-stage, hormone receptor-positive breast cancer. JAMA Netw Open. 2022;5(8):e2225485. Torres JM, Sodipo MO, Hopkins MF, Chandler PD, Warner ET. Racial differences in breast cancer survival between Black and White women according to tumor subtype: a systematic review and meta-analysis. J Clin Oncol. 2024;42(35):4225–4234. Bailey ZD, Krieger N, Agénor M, Graves J, Linos N, Bassett MT. Structural racism and health inequities in the USA: evidence and interventions. Lancet. 2017;389(10077):1453–1463.Hypertension. 2026;83:00–00. DOI: 10.1161/HYPERTENSIONAHA.125.25787Allen RH, Bartz D. Opill: The Over-the-Counter Contraceptive Pill. Obstet Gynecol. 2024;143(2):184-188. doi:10.1097/AOG.0000000000005455 Cahill EP, Kaur S. Advances in contraception research and development. Curr Opin Obstet Gynecol. 2020;32(6):393-398. doi:10.1097/GCO.0000000000000666 Charles DN, Nagarsheth M, Oshman L. Pain Management for IUD Insertion in Primary Care. Am Fam Physician. 2025;111(4):299-301. Chen, C., Strasser, J., Banawa, R., Luo, Q., Bodas, M., Castruccio-Prince, C., Das, K., & Pittman, P. (2022). Who is providing contraception care in the United States? An observational study of the contraception workforce. American journal of obstetrics and gynecology, 226(2), 232.e1–232.e11. https://doi.org/10.1016/j.ajog.2021.08.015 Diedrich,J., Klein, D. Peipert, J...
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    41 分
  • Recalculating Risk: Updated Guidelines for Lipid Management - Frankly Speaking Ep 499

    Recalculating Risk: Updated Guidelines for Lipid Management - Frankly Speaking Ep 499
    2026/08/24

    Credits: 0.25 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-499

    Overview: Stay in the know with this breakdown of the latest American College of Cardiology (ACC)/American Heart Association (AHA) recommendations for lipid testing and management. New approaches to evaluating hyperlipidemia, as well as limitations of the updated guidelines, are discussed to provide you with practical strategies for tailoring treatment decisions to individual patient risk.

    Episode resource links:

    • Writing Committee Members, Blumenthal RS, Morris PB, et al. 2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2026;153(17):e1154-e1276.

    Guest: Alan M. Ehrlich, MD, FAAFP Music Credit: Matthew Bugos

    Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com

    The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.
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    15 分
  • The Menopause Reset: Recognizing Symptoms and Rethinking Hormones - Frankly Speaking Ep 498

    The Menopause Reset: Recognizing Symptoms and Rethinking Hormones - Frankly Speaking Ep 498
    2026/08/17

    Credits: 0.25 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-498

    Overview: Ahead of her keynote address that will more comprehensively dive into menopause symptoms management, Dr. Rachel Rubin sits down with Frank to discuss common menopause symptoms that aren't being addressed in primary care, and the implications of the recent FDA label changes on hormone treatments.

    Guest: Rachel Rubin, MD Music Credit: Matthew Bugos

    Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com

    The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.
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    14 分
  • 2026 ACC/AHA Dyslipidemia Guideline Review: Getting to the Heart of the Evidence - Frankly Speaking Ep 497

    2026 ACC/AHA Dyslipidemia Guideline Review: Getting to the Heart of the Evidence - Frankly Speaking Ep 497
    2026/08/10

    Credits: 0.25 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-497

    Overview: While the 2026 ACC/AHA dyslipidemia guidelines may seem overwhelming, we’ve got you covered. Join us as we walk through the latest recommendations—from risk calculation to treatment targets to testing—and take a close look at the rationale behind the guidelines, so you can guide patients with confidence.

    Episode resource links:

    • JACC. Published online March 13, 2026. doi: 10.1016/j.jacc.2025.11.016
    • NEJM: 2026;394:1365-1375 DOI: 10.1056/NEJMoa2600283
    • JAMA. 2022;328(8):754–771. doi:10.1001/jama.2022.12138

    Guest: Robert A. Baldor MD, FAAFP Music Credit: Matthew Bugos

    Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com

    The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.
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    17 分
  • The Cannabis Conversation: Discussing the Risks with Adolescent Patients - Frankly Speaking Ep 496

    The Cannabis Conversation: Discussing the Risks with Adolescent Patients - Frankly Speaking Ep 496
    2026/08/03

    Credits: 0.25 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-496

    Overview: Adolescents who use cannabis—especially at a younger age or higher frequency—face substantially elevated risks of mood and psychiatric disorders. Listen in to hear practical, evidence-based strategies for screening teens for substance use, counseling patients and families, and recognizing the significant risks associated with adolescent cannabis use.

    Episode resource links:

    • Young-Wolff KC, Cortez CA, Alexeeff SE, et al. Adolescent Cannabis Use and Risk of Psychotic, Bipolar, Depressive, and Anxiety Disorders. JAMA Health Forum. 2026;7(2):e256839. doi:10.1001/jamahealthforum.2025.6839
    • American Academy of Pediatrics - Substance Use and Prevention

    Guest: Jillian Joseph, MPAS, PA-C Music Credit: Matthew Bugos

    Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com

    The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.
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    14 分
  • Statins—Time to Stop the Worry! - Frankly Speaking Ep 495

    Statins—Time to Stop the Worry! - Frankly Speaking Ep 495
    2026/07/27

    Credits: 0.25 AMA PRA Category 1 Credit™ CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-495

    Overview: Statin prescription labels and case reports list a variety of potential treatment-related adverse effects that often raise concerns about their safety. In this episode, we review the evidence for such effects from a recently published study of statin therapy, giving you confidence to counsel worried patients.

    Episode resource links:

    • Explain the concerns over potential negative effects from statin use
    • Outline the latest research demonstrating statin safety

    Guest: Robert A. Baldor MD, FAAFP Music Credit: Matthew Bugos

    Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com

    The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.
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    11 分