Can Christian McCaffrey's return ignite the San Francisco 49ers' offense against the Tampa Bay Buccaneers? With McCaffrey back in action, the 49ers aim to exploit the Buccaneers' defensive vulnerabilities, especially in the red zone, during this pivotal NFL matchup.

This episode breaks down the keys to victory for the 49ers, including George Kittle's potential to shine by exploiting the middle of the field. The hosts discuss the importance of rattling Baker Mayfield early and effectively covering Cade Otton, given the Buccaneers' depleted receiving corps. Injury updates, including Charvarius Ward's absence, and the impact of Khalil Davis joining the 49ers' defensive line are also covered. Fantasy football enthusiasts will find insights on how McCaffrey's return could shake up lineups.

San Francisco 49ers fans are treated to daily news and analysis with Locked On 49ers, hosted by football analyst Brian Peacock and former NFL/AFL cornerback Eric Crocker.

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🎧 https://link.chtbl.com/LO49ers?sid=YouTube

Locked On NFL League-Wide: Every Team, Fantasy, Draft & More

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Follow Brian Peacock and Eric Crocker on Twitter, where they’ll be sharing the latest news about the Niners and talking with fans.

Twitter: twitter.com/BDPeacock, twitter.com/eric_crocker

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