A night spent sleeping on dirt and leaves is not how Claire Matchett expected to spend her vacation. She thought this would be a break. A week of hiking and hot tubs with two other couple friends. Then Claire’s minivan breaks down on a lonely dirt road. With no cell reception, the group has no choice but to hike the rest of the way to their hotel. But it turns out the woods aren’t as easy to navigate as they thought. Hours later, they are lost. Hopelessly lost. And as they navigate deeper into the woods, the members of their party are struck down mysteriously one by one.

Tess Strebel can’t recognize her own face. She can’t recognize her home. Her bedroom is unfamiliar. And she can’t remember the handsome stranger lying next to her in bed. A stranger who claims he’s her husband. Tess reads a letter in her own handwriting, composed during a rare lucid day, explaining her life as it now exists: she was in a terrible car accident one year ago. Every morning, she wakes up unable to remember most of the last decade. Including her own wedding.

Medical student Amy Brenner is spending the night on a locked psychiatric ward. Amy has been dreading her evening working on Ward D, the hospital’s inpatient mental health unit. There are very specific reasons why she never wanted to do this required overnight rotation. Reasons nobody can ever find out. And as the hours tick by, Amy grows increasingly convinced something terrible is happening within these tightly secured walls.

Victoria Barnett has it all: a great career as a nurse practitioner, a handsome and loving husband, a beautiful home in the suburbs, and a plan to fill it with children. Life is perfect—or so it seems. Then she’s in a terrible accident...and everything falls apart. Now Victoria is unable to walk. She can’t feed or dress herself. She can’t even speak. She is confined to the top floor of her house with 24-hour care.

Erika Cass has a perfect family and a perfect life. Until the evening when two detectives show up at her front door. A high school girl has vanished from Erika's quiet suburban neighborhood. The police suspect the worst - murder. And Erika's teenage son, Liam, was the last person to see the girl alive. Erika has always sensed something dark and disturbed in her seemingly perfect older child. She wants to believe he's innocent, but as the evidence mounts, she can't deny the truth - Liam may have done the unthinkable.