Joanne knows how lucky she is—Richard is a wonderful husband, Evie is the most gorgeous baby girl, they live in a beautiful house—life couldn't be better. But then Richard's twenty-year-old daughter Chloe turns up. Chloe hasn’t spoken to her father since the day he married Joanne two years ago. But with the arrival of her baby sister Evie, Chloe wants to make peace. Richard is delighted, and since Joanne is struggling with the new baby, he suggests Chloe could move in and help.

Psychiatrist Dr. Gwen Moore is an expert on killers. She’s spent a decade treating California’s most depraved predators and unlocking their motives - predators much like the notorious Bloody Heart serial killer, whose latest teenage victim escaped and then identified local high school teacher Randall Thompson as his captor. The case against Thompson as the Bloody Heart Killer is damning - and closed, as far as Gwen and the media are concerned. If not for one new development.

Cassie thinks she has met the perfect man. Joel is sweet, handsome, romantic, and best of all, he’s crazy about Cassie. She thinks she’s found the guy she’ll spend the rest of her life with. Have children with. Grow old with. Yes, she knows about his perfect ex-girlfriend, Francesca. The beautiful, brilliant chef, beloved by all his friends. But she thinks Francesca is out of the picture. She thinks Francesca is gone for good. Think again, Cassie.

Medical student Amy Brenner is spending the night on a locked psychiatric ward. Amy has been dreading her evening working on Ward D, the hospital’s inpatient mental health unit. There are very specific reasons why she never wanted to do this required overnight rotation. Reasons nobody can ever find out. And as the hours tick by, Amy grows increasingly convinced something terrible is happening within these tightly secured walls.

Newly minted doctor Jane McGill is in hell. Not literally, of course. But between her drug addict patients, sleepless nights on call, and battling wits with the sadistic yet charming Sexy Surgeon, Jane can’t imagine an afterlife much worse than her first month of medical internship at County Hospital. And then there’s the devil herself: Jane’s senior resident Dr. Alyssa Morgan. When Alyssa becomes absolutely hell-bent on making her new interns pay tenfold for the deadly sin of incompetence, Jane starts to worry that she may not make it through the year with her soul or her sanity still intact.