Carl and Laralee and their team of scientists are hired by the Spanish government to develop a highly secret, revolutionary serum. Their goal: to create an army of carnivorous monkeys that would give Spain an indisputable advantage over its enemies.

They succeed beyond their wildest dreams. However, greatly increased intelligence is an unexpected side effect that causes serious complications. The beasts are thinking, reasoning, and turning out to be increasingly dangerous. After one death and several serious attacks on workers, the scientific team is relieved to learn their request to move the facility to a larger island with more security and built-in safeguards is approved.

Additional experiments with orangutans prove successful, as well. James and Julie - the most advanced, skilled, and lovable of the facility’s apes - have mated. Will they produce the amazingly intelligent offspring the team expects?

During the facility’s relocation, a terrible storm wreaks havoc and washes man and beast up onto a deserted island that turns out to be anything but a safe haven. Carl and Laralee, Doc Gustav and Teresa, and the rest of the team battle for survival against their own nightmarish creations.

Who will survive?