Still haunted by the disappearance of his little sister, Amy, over 20 years ago, Joseph Bridgeman’s life has fallen apart. When a friend talks him into seeing hypnotherapist Alexia Finch to help with his insomnia, Joseph accidentally discovers he can time travel. His first trip only takes him back a few minutes, but his new-found ability gives him something he hasn’t felt for the longest time: hope.

Newlyweds Tricia and Ethan are searching for the house of their dreams. But when they visit the remote manor that once belonged to Dr. Adrienne Hale, a renowned psychiatrist who vanished without a trace four years earlier, a violent winter storm traps them at the estate… with no chance of escape until the blizzard comes to an end. In search of a book to keep her entertained until the snow abates, Tricia happens upon a secret room. One that contains audio transcripts from every single patient Dr. Hale has ever interviewed.

Victoria Barnett has it all: a great career as a nurse practitioner, a handsome and loving husband, a beautiful home in the suburbs, and a plan to fill it with children. Life is perfect—or so it seems. Then she’s in a terrible accident...and everything falls apart. Now Victoria is unable to walk. She can’t feed or dress herself. She can’t even speak. She is confined to the top floor of her house with 24-hour care.

On his thirty-sixth birthday, Travis Cornell hikes into the foothills of the Santa Ana Mountains. But his path is soon blocked by a bedraggled Golden Retriever who will let him go no further into the dark woods. That morning, Travis had been desperate to find some happiness in his lonely, seemingly cursed life. What he finds is a dog of alarming intelligence that soon leads him into a relentless storm of mankind’s darkest creation....

Traumatized by the bombing of Dresden at the time he had been imprisoned, Pilgrim drifts through all events and history, sometimes deeply implicated, sometimes a witness. He is surrounded by Vonnegut's usual large cast of continuing characters (notably here the hack science fiction writer Kilgore Trout and the alien Tralfamadorians, who oversee his life and remind him constantly that there is no causation, no order, no motive to existence).