• Authentic Biochemistry Podcast. Alzheimer’s Disease coda. Dr Daniel J Guerra.04sept24

  • 2024/09/05
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Authentic Biochemistry Podcast. Alzheimer’s Disease coda. Dr Daniel J Guerra.04sept24

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  • Correction:

    In my lecture I incorrectly used the W single letter designation as representing tyrosine. I miss-spoke.

    W=tryptophan while Y=tyrosine.

    The WW domain discussion is important for specific protein:protein interactions wherein the tryptophan (W) residues (found in the beta1 and beta 3 folds) are separated by 20 -22 amino acids that contain certain tyrosine (Y) residues in the beta2 region which may become phosphorylated thus generating phosophotyrosine binding (PTB)domains that are recognized by other proteins.

    I apologize for the error.




    References

    Exp Biol Med (Maywood). 2015 Mar; 240(3):375–382

    Cellular Physiology and Biochemistry (2017) 41 (3): 1189–1198.

    PNAS 2022 Sep6;119(36):e2204069119

    Alzheimer's Research & Therapy.2024.volume 16, Article number: 144 Joel, B. 1977. Vienna [Strangers;lp]

    https://open.spotify.com/track/4U45aEWtQhrm8A5mxPaFZ7?si=240c0d811f164b7c

    Beethoven, LV. 1816. Seventh Symphony A major. Op92.

    https://open.spotify.com/album/2kDHEJxutXleLTNCctvgSB?si=qefvirqXSviiOqPmvWME7w


    --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
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あらすじ・解説

Correction:

In my lecture I incorrectly used the W single letter designation as representing tyrosine. I miss-spoke.

W=tryptophan while Y=tyrosine.

The WW domain discussion is important for specific protein:protein interactions wherein the tryptophan (W) residues (found in the beta1 and beta 3 folds) are separated by 20 -22 amino acids that contain certain tyrosine (Y) residues in the beta2 region which may become phosphorylated thus generating phosophotyrosine binding (PTB)domains that are recognized by other proteins.

I apologize for the error.




References

Exp Biol Med (Maywood). 2015 Mar; 240(3):375–382

Cellular Physiology and Biochemistry (2017) 41 (3): 1189–1198.

PNAS 2022 Sep6;119(36):e2204069119

Alzheimer's Research & Therapy.2024.volume 16, Article number: 144 Joel, B. 1977. Vienna [Strangers;lp]

https://open.spotify.com/track/4U45aEWtQhrm8A5mxPaFZ7?si=240c0d811f164b7c

Beethoven, LV. 1816. Seventh Symphony A major. Op92.

https://open.spotify.com/album/2kDHEJxutXleLTNCctvgSB?si=qefvirqXSviiOqPmvWME7w


--- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support
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