The intricate relationship between obstructive sleep apnea syndrome (OSA), gut health, and their associated health consequences has been the subject of numerous scientific studies. The three selected papers delve into this relationship, exploring the role of obesity, gut microbiota, and cognitive dysfunction in O.S.A. By comparing and contrasting these studies, we aim to provide a cohesive understanding of the pathogenesis and potential interventions for this disorder.

Follow us on social media!

• Instagram and TikTok: @agora_health
• Facebook Page: Agora Health
• Youtube Channel: Agora Health

References:

1. Kuvat N, Tanriverdi H, Armutcu F. The relationship between obstructive sleep apnea syndrome and obesity: A new perspective on the pathogenesis in terms of organ crosstalk. The clinical respiratory journal. 2020 Jul;14(7):595-604.

Link: https://onlinelibrary.wiley.com/doi/10.1111/crj.13175

2. Durgan DJ. Obstructive sleep apnea-induced hypertension: role of the gut microbiota. Current hypertension reports. 2017 Apr;19(4):35.

Link: https://link.springer.com/article/10.1007/s11906-017-0732-3

3. Deyang T, Baig AI, Dolkar P, Hediyal TA, Rathipriya AG, Bhaskaran M, PandiPerumal SR, Monaghan TM, Mahalakshmi AM, Chidambaram SB. Sleep apnoea, gut dysbiosis and cognitive dysfunction. The FEBS Journal. 2023 Sep 4.

Link: https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.16960

In this episode: Suicidal behaviors and thoughts, along with their tragic consequences, have been the subject of scientific investigation across the globe. Genetics is a burgeoning field of research in this context, with studies increasingly probing the intricate relationships between genetic markers, epigenetic factors, and predispositions towards self-harm and suicidal tendencies. The following is a comparative review of three paramount studies in this area.

Follow us on social media!

• Instagram and TikTok: @agora_health
• Facebook Page: Agora Health
• Youtube Channel: Agora Health

References:

1- Li QS, Shabalin AA, DiBlasi E, Gopal S, Canuso CM, FinnGen, International Suicide Genetics Consortium, Palotie A, Drevets WC, Docherty AR, Coon H. Genome-wide association study meta-analysis of suicide death and suicidal behavior. Molecular psychiatry. 2023 Feb;28(2):891-900.

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9908547/

2- Erlangsen A, Appadurai V, Wang Y, Turecki G, Mors O, Werge T, Mortensen PB, Starnawska A, Børglum AD, Schork A, Nudel R. Genetics of suicide attempts in individuals with and without mental disorders: a population-based genome-wide association study. Molecular Psychiatry. 2020 Oct;25(10):2410-21.

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7515833/

3- Mirza S, Docherty AR, Bakian A, Coon H, Soares JC, Walss‐Bass C, Fries GR. Genetics and epigenetics of self‐injurious thoughts and behaviors: Systematic review of the suicide literature and methodological considerations. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2022 Oct;189(7-8):221-46.

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900606/

In this episode: Three papers delve into the potential link between labor epidural analgesia (LEA) and postpartum depression (PPD). These studies, each employing different methodologies and sample sizes, aim to provide insights into whether the use of L.E.A during labor influences the onset or prevalence of P.P.D.

Follow us on social media!

• Instagram and TikTok: @agora_health
• Facebook Page: Agora Health
• Youtube Channel: Agora Health

References:

1. Almeida M, Kosman KA, Kendall MC, De Oliveira GS. The association between labor epidural analgesia and postpartum depression: a systematic review and meta-analysis. BMC women's health. 2020 Dec;20(1):1-7.

Link: https://bmcwomenshealth.biomedcentral.com/articles/10.1186/s12905-020-00948-0

2. Edipoglu IS, Aslan DD. Association of postpartum depression and epidural analgesia in women during labor: an observational study. Brazilian Journal of Anesthesiology. 2021 Jun 30;71:208-13.

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9373269/

3. Kountanis JA, Vahabzadeh C, Bauer S, Muzik M, Cassidy R, Aman C, MacEachern M, Bauer ME. Labor epidural analgesia and the risk of postpartum depression: a meta-analysis of observational studies. Journal of clinical anesthesia. 2020 May 1;61:109658.

The intricate relationship between sleep patterns and pregnancy remains a vital area of exploration in perinatal research. As sleep disruptions can significantly impact both the mother and fetus, a deeper understanding of these patterns is essential. This comparative analysis delves into three pivotal studies on the subject, contrasting their methodologies, findings, and broader implications to highlight the unique and complementary insights they each provide.

Follow us on social media!

• Instagram and TikTok: @agora_health
• Facebook Page: Agora Health
• Youtube Channel: Agora Health

References:

1. Dunietz GL, Sever O, DeRowe A, Tauman R. Sleep position and breathing in late pregnancy and perinatal outcomes. Journal of Clinical Sleep Medicine. 2020 Jun 15;16(6):955-9.

Link: https://jcsm.aasm.org/doi/10.5664/jcsm.8416

2. Sedov ID, Cameron EE, Madigan S, Tomfohr-Madsen LM. Sleep quality during pregnancy: a meta-analysis. Sleep medicine reviews. 2018 Apr 1;38:168-76.

Link:https://www.sciencedirect.com/science/article/abs/pii/S1087079217300291?via%3Dihub

3. Zhao P, Bedrick BS, Brown KE, McCarthy R, Chubiz JE, Ju YE, Raghuraman N, Fay JC, Jungheim ES, Herzog ED, England SK. Sleep behavior and chronotype before and throughout pregnancy. Sleep Medicine. 2022 Jun 1;94:54-62.

Link:https://www.sciencedirect.com/science/article/abs/pii/S1389945722001241?via%3Dihub

In today's episode: Three papers address this pressing issue from diverse vantage points, delving into the implications of repetitive concussions, examining cognitive functions in retired rugby players, and identifying predictors of clinical recovery.

Follow us on social media!

• Instagram and TikTok: agora_health
• Facebook Page: Agora Health
• Youtube Channel: Agora Health

References:

1. McAllister T, McCrea M. Long-term cognitive and neuropsychiatric consequences of repetitive concussion and head-impact exposure. Journal of athletic training. 2017 Mar 1;52(3):309-17.

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384827/

2. Gallo V, McElvenny DM, Seghezzo G, Kemp S, Williamson E, Lu K, Mian S, James L, Hobbs C, Davoren D, Arden N. Concussion and long‐term cognitive function among rugby players—The BRAIN Study. Alzheimer's & Dementia. 2022 Jun;18(6):1164-76.

Link: https://pubmed.ncbi.nlm.nih.gov/34668650/

3. Iverson GL, Gardner AJ, Terry DP, Ponsford JL, Sills AK, Broshek DK, Solomon GS. Predictors of clinical recovery from concussion: a systematic review. British journal of sports medicine. 2017 Jun 1;51(12):941-8.

Link: https://bjsm.bmj.com/content/51/12/941

In this episode: A consolidated review on maternal obesity and Its multifaceted implications on offspring health.

Follow us on social media!

• Instagram and TikTok: agora_health
• Facebook Page: Agora Health
• Youtube Channel: Agora Health

References:

1. Rubini E, Schenkelaars N, Rousian M, Sinclair KD, Wekema L, Faas MM, Steegers-Theunissen RP, Schoenmakers S. Maternal obesity during pregnancy leads to derangements in one-carbon metabolism and the gut microbiota: Implications for fetal development and offspring wellbeing. American Journal of Obstetrics and Gynecology. 2022 Sep 1;227(3):392-400.

Link: https://www.ajog.org/article/S0002-9378(22)00285-X/fulltext

2. Langley‐Evans SC, Pearce J, Ellis S. Overweight, obesity and excessive weight gain in pregnancy as risk factors for adverse pregnancy outcomes: a narrative review. Journal of Human Nutrition and Dietetics. 2022 Apr;35(2):250-64.

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9311414/

3. Godfrey KM, Reynolds RM, Prescott SL, Nyirenda M, Jaddoe VW, Eriksson JG, Broekman BF. Influence of maternal obesity on the long-term health of offspring. The lancet Diabetes & endocrinology. 2017 Jan 1;5(1):53-64.

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5245733/

In this episode, find a summary that delves into three pivotal papers that elucidate the multifaceted benefits of exercise, covering its molecular benefits, its effects on body composition in older Hispanics with type 2 diabetes, and its potential as a treatment for depression in seniors.

Follow us on social media!

• Instagram and TikTok: agora_health
• Facebook Page: Agora Health
• Youtube Channel: Agora Health

References:

1. Guan Y, Yan Z. Molecular mechanisms of exercise and healthspan. Cells. 2022 Mar 3;11(5):872.

Link: https://www.mdpi.com/2073-4409/11/5/872

2. Vieira ER, Cavalcanti FA, Civitella F, Hollifield M, Caceres S, Carreno J, Gaillard T, Huffman FG, Mora JC, Queiroga MR. Effects of exercise and diet on body composition and physical function in older Hispanics with type 2 diabetes. International Journal of Environmental Research and Public Health. 2021 Jul 29;18(15):8019.

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8345658/

3. López-Torres Hidalgo J. Effectiveness of physical exercise in the treatment of depression in older adults as an alternative to antidepressant drugs in primary care. BMC psychiatry. 2019 Dec;19(1):1-7.

Link: https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-018-1982-6

In this episode find a summary that synthesizes three key papers that explore the relationship between LDL-C and various health outcomes, primarily focusing on mortality.

• Instagram and TikTok: @agora_health
• Facebook Page: Agora Health
• Youtube Channel: Agora Health

References:

1. Johannesen CD, Langsted A, Mortensen MB, Nordestgaard BG. Association between low density lipoprotein and all cause and cause specific mortality in Denmark: prospective cohort study. Bmj. 2020 Dec 8;371.

Link: https://www.bmj.com/content/371/bmj.m4266.long

2. Navarese EP, Robinson JG, Kowalewski M, Kołodziejczak M, Andreotti F, Bliden K, Tantry U, Kubica J, Raggi P, Gurbel PA. Association between baseline LDL-C level and total and cardiovascular mortality after LDL-C lowering: a systematic review and meta-analysis. Jama. 2018 Apr 17;319(15):1566-79.

Link: https://jamanetwork.com/journals/jama/fullarticle/2678614

3. Ennezat PV, Guerbaai RA, Maréchaux S, Le Jemtel TH, François P. Extent of Low-density Lipoprotein Cholesterol Reduction and All-cause and Cardiovascular Mortality Benefit: A Systematic Review and Meta-analysis. Journal of Cardiovascular Pharmacology. 2023 Jan;81(1):35.

Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812424/