In this series, we dive into what rheumatologists should know about pulmonary hypertension, starting an interview with Joseph Parambil, MD, where we learn about the disease, when to suspect and how to work up!

• Intro 0:11
• In this episode 0:16
• Preview of the four-part series 4:46
• Interview with Joseph Parambil, MD 6:27
• How did you become interested in pulmonary hypertension? 7:02
• Brown and Parambil discuss the histology of pulmonary hypertension. 10:13
• Brown and Parambil discuss a case of pulmonary hypertension. 12:26
• What is pulmonary hypertension and what does that mean for a rheumatologist? Where is pulmonary hypertension happening? 13:25
• Describe the different groups of pulmonary hypertension. 19:51
• A note about Dr. Chatterjee 20:25
• Brown and Parambil discuss the groups of pulmonary hypertension. 23:35
• What should we know about evaluating patients with pulmonary hypertensions? 26:51
• Brown and Parambil discuss bendopnea and other signs of pulmonary hypertension. 29:58
• What about the heart sound? 33:06
• What should we look for in patients who we suspect to have pulmonary hypertension? 36:52
• What should we look for in the tricuspid jet? 38:18
• Brown and Parambil discuss the use of echocardiograms in pulmonary hypertension. 39:28
• Tell us about the threshold of diagnosis. 40:47
• What is the difference between the mean pressure and the wedge pressure? 41:41
• What about the role of the pulmonary function test? 43:55
• Summary 46:41
• Do you think the pulmonary hypertension in scleroderma and lupus are different entities? 48:37
• Brown and Parambil discuss the connection of autoimmune disease and pulmonary hypertension. 50:49
• Coming up in episode 91 51:50
• Thanks for listening 52:25

Disclosures: Brown and Parambil report no relevant financial disclosures.

Joseph Parambil, MD, is a staff member in the Respiratory Institute and the director of the HHT Center of Excellence and the Vascular Anomalies Center at the Cleveland Clinic. He is associate professor of medicine at Cleveland Clinic’s Lerner College of Medicine. He is certified by the American Board of Internal Medicine with additional specialty certification in pulmonary medicine and critical care medicine.

We’d love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum.

On this episode, hear the 2024 updates on COVID-19, long COVID and the latest developments in research in rheumatology. Hosted by Dr. Leonard Calabrese.

• Intro 0:12
• In this episode 0:21
• Coming up on Healio Rheuminations 0:56
• COVID-19, long COVID and the rheumatologist with Leonard Calabrese, DO 2:19
• Questions 3:12
• Long COVID 4:46
• Calabrese’s bias 10:15
• The evidence 13:08
• Auto antibodies 14:54
• Why does the body develop auto antibodies? 17:47
• COVID-19 and epidemiologic association 22:25
• New clinical entity 26:40
• Therapeutic implications 31:00
• In conclusion 32:00
• Thanks for listening 33:18

Leonard H. Calabrese, DO, is the chief medical editor, Healio Rheumatology, and professor of medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, and RJ Fasenmyer chair of clinical immunology at the Cleveland Clinic.

Disclosures: Calabrese reports professional relationships with AbbVie, AstraZeneca, Bristol Myers Squibb, Galvani, Genentech, GlaxoSmithKline, Janssen, Novartis, Regeneron, Sanofi and UCB.

We’d love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum.

It's that time of year again, everyone rolling up their sleeves to get a flu shot. This throwback episode dives into the history of the struggles pinning down the causative agent of flu and the journey to the vaccine!

• Intro 0:40
• In this episode 1:11
• The history of the flu: 1892 1:41
• What do we know about viruses? 6:29
• Rabies and dead virus 11:17
• A Sickness in the Serum, Part 2 14:43
• 1918 16:44
• Vaccines and trials 19:13
• Pig influenza 23:12
• Influenza: a filterable agent we can’t see 27:01
• The trials of 1942 33:02
• PS: 1918 influenza 38:57
• Thanks for listening 47:42

Disclosures: Brown reports no relevant financial disclosures.

We’d love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum.

References:

Hicks DJ, et al. Clin Exp Immunol. 2012;doi:10.1111/j.1365-2249.2012.04592.x.

Rosenau MJ. Experiments Upon Volunteers to Determine the Cause and Mode of Spread of Influenza, Boston, November and December, 1918. https://quod.lib.umich.edu/f/flu/3750flu.0016.573. Published February 1921. Accessed December 6, 2023.

Rosenau MJ, et al. JAMA. 1925;doi:10.1001/jama.1925.02670070040019.

Taubenberger JK, et al. Antivir Ther. 2007;12(4 Pt B):581-91.

Tobin J. The first flu shot. https://heritage.umich.edu/stories/the-first-flu-shot/. Accessed December 6, 2023.