Dr. Edward A. Botchwey is a Professor in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University. His research focuses on advancing regenerative medicine and immunoengineering through a convergence approach that integrates various disciplines and techniques for tissue repair and regeneration. Dr. Botchwey’s lab has made significant contributions in investigating S1P signaling in tissue repair and engineering in vivo gradients for microvascular remodeling, as well as developing regenerative immunotherapies using specialized pro-resolving lipid mediators (SPMs) and hydrogel-based delivery systems. This talk will mainly focus on targeting S1P signaling to promote tissue repair and regeneration, including the use of sphingosine kinase inhibitors (SK1i) to reduce local S1P levels and promote muscle fiber regeneration. Additionally, the development and application of ApoM-Fc-S1P, a novel S1P chaperone that enhances S1P receptor 1 signaling, will be discussed, highlighting its role in reducing fibrosis and improving muscle healing, particularly in aged animals. Advanced drug delivery systems such as nanofiber scaffolds and hydrogels, which provide localized and sustained release of therapeutic agents like FTY720, will also be introduced. These delivery systems enhance the efficacy of S1P-targeted therapies by ensuring higher drug concentration at the injury site, facilitating better integration and healing. The presentation will cover the use of ultrasound elastography as a noninvasive imaging technique to monitor tissue stiffness and fibrosis, providing valuable insights into the therapeutic efficacy of these approaches. Dr. Botchwey aims to develop innovative, equity-centered solutions to complex challenges in regenerative medicine, with potential applications in diverse fields such as regenerative immunotherapies, metabolic and hematologic disorders, and cell and tissue transplantation. Additionally, he is actively involved in promoting diversity and outreach through programs like SURE (Summer Undergraduate Research Experience) and ENGAGES (Engaging New Generations at Georgia Tech through Engineering and Science), which aim to provide underrepresented students with research opportunities and inspire the next generation of scientists and engineers. ---- Note: The views of this podcast represent those of my guest(s) and I. Note: Purpose of these episodes- not at all, for advice or medical suggestions. These are aimed to provide support for peer pharmacists in training in educational and intellectually stimulating ways. Again, these are not at all for medical advice, or for medical suggestions. Please see your local state and board-certified physician, PA or NP, and pharmacist for medical advice and suggestions.