Africa's public health landscape is again at the centre of global health attention with a series of actions now in play to stem the spread of mpox. This week, the Africa Centres for Disease Control and Prevention will officially declare mpox a public health emergency of continental concern. This is expected to be historic since this is the first time that the centre would be making such a declaration. Similarly, a closed virtual meeting of the Emergency Committee convened by the WHO Director-General under the International Health Regulations 2005 regarding the upsurge of mpox has been set for Wednesday, 14 August 2024, starting the official process that could lead to declaration of mpox as a public health emergency of international concern by the director general of the WHO. In this episode, I am joined by Aggrey Aluso who is Pandemic Action Network’s Director for the Africa region. The conversation focused on Africa's rapidly evolving public health landscape, particularly in relation to the MPOX outbreak. We discussed the challenges Africa faces in responding to infectious disease outbreaks and the need for increased capacity and resources, highlighting the importance of early action and collaboration, both within Africa and globally, to contain outbreaks. The conversation also touched on the need to prioritize health in national budgets and the role of civil society in holding governments accountable. My name is Paul Adepoju, and I welcome you to this episode.