Managing Patients With Neurotrophic Keratitis (NK)

著者： Annenberg Center for Health Sciences
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  • サマリー

  • The treatment of patients with NK, a rare disease of the eye that can lead to blindness, has evolved beyond treating symptoms to treatment that targets the root cause of the disease – nerve damage. Thus, early diagnosis is critical. Faculty discuss the etiology, diagnosis, staging, and treatment of patients with NK. In addition to an overview of symptomatic care and emerging treatments, the safety, efficacy, storage, and administration of cenegermin are explained in detail. Clinical and real-world questions are discussed, related to patient education, provided by multidisciplinary faculty.
    Annenberg Center for Health Sciences
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あらすじ・解説

The treatment of patients with NK, a rare disease of the eye that can lead to blindness, has evolved beyond treating symptoms to treatment that targets the root cause of the disease – nerve damage. Thus, early diagnosis is critical. Faculty discuss the etiology, diagnosis, staging, and treatment of patients with NK. In addition to an overview of symptomatic care and emerging treatments, the safety, efficacy, storage, and administration of cenegermin are explained in detail. Clinical and real-world questions are discussed, related to patient education, provided by multidisciplinary faculty.
Annenberg Center for Health Sciences
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エピソード
  • Patient Education & Cases

    Patient Education & Cases
    2024/06/05
    • Principles
    • Case #1
    • Case #2

    Key Concepts:

    • Patient education about the disease and its natural history if left untreated is important
    • Interprofessional, multidisciplinary care is associated with the best patient outcomes
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    13 分
  • Treatment

    Treatment
    2024/06/05
    • Team-based care
    • Treatment
      • General care
      • Prevention
      • Symptomatic treatment
      • Cenegermin
        • Safety, efficacy, role in treatment/patient selection
        • Cost
        • Storage and administration
      • Corneal neurotization
      • Investigational therapies

    Key Concepts:

    • Most patients should receive basic preventive and symptomatic care, as well as active treatment in certain cases
    • Cenegermin promotes corneal healing and is the only medication approved for the treatment of patients with neurotrophic keratitis
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    20 分
  • Screening & Diagnosis

    Screening & Diagnosis
    2024/06/05
    • Clinical manifestations
    • Screening
    • Tools to test corneal sensitivity
    • Diagnostic algorithm
    • Disease staging
    • Considerations for referral

    Key Concepts:

    • Patients who are candidates for screening include those with a variety of genetic, system, central nervous system, or ocular diseases, such as diabetes mellitus, multiple sclerosis, and Alzheimer’s disease, or who us contact lenses or eyedrops with preservatives
    • Corneal sensitivity can be tested various ways and is critical to make the diagnosis
    • Cenegermin is self-administered and requires the patient be thoroughly educated regarding storage, handling, and administration
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    21 分

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