Join Drs Nihar Desai and Matthew Cavender as they discuss the history, studies, and implementation of GLP-1 receptor agonists for people with cardiorenal metabolic syndrome.

Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/999842. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Glucagon-Like Peptide-1 Receptor Agonists https://www.ncbi.nlm.nih.gov/books/NBK551568/#:~:text=Glucagon%2Dlike%20peptide%2D1%20(,options%20for%20these%20endocrine%20diseases.

Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death From Cardiovascular Causes https://pubmed.ncbi.nlm.nih.gov/17517853/

Guidance for Industry on Diabetes Mellitus-Evaluating Cardiovascular Risk in New Antidiabetic Therapies to Treat Type 2 Diabetes; Availability https://www.federalregister.gov/documents/2008/12/19/E8-30086/guidance-for-industry-on-diabetes-mellitus-evaluating-cardiovascular-risk-in-new-antidiabetic

Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes https://pubmed.ncbi.nlm.nih.gov/27295427/

Effects of Oral Semaglutide on Cardiovascular Outcomes in Individuals With Type 2 Diabetes and Established Atherosclerotic Cardiovascular Disease and/or Chronic Kidney Disease: Design and Baseline Characteristics of SOUL, a Randomized Trial https://pubmed.ncbi.nlm.nih.gov/36945734/

Semaglutide and Cardiovascular Outcomes in Obesity Without Diabetes https://pubmed.ncbi.nlm.nih.gov/37952131/

Heart Failure With Preserved Ejection Fraction (HFpEF) https://www.ncbi.nlm.nih.gov/books/NBK599960/

Effects of Liraglutide on Clinical Stability Among Patients With Advanced Heart Failure and Reduced Ejection Fraction: A Randomized Clinical Trial https://pubmed.ncbi.nlm.nih.gov/27483064/

Semaglutide Versus Placebo in People With Obesity-Related Heart Failure With Preserved Ejection Fraction: A Pooled Analysis of the STEP-HFpEF and STEP-HFpEF DM Randomised Trials https://pubmed.ncbi.nlm.nih.gov/38599221/

Interpreting the Kansas City Cardiomyopathy Questionnaire in Clinical Trials and Clinical Care: JACC State-of-the-Art Review https://pubmed.ncbi.nlm.nih.gov/33183512/

Comparison of Tirzepatide and Dulaglutide on Major Adverse Cardiovascular Events in Participants With Type 2 Diabetes and Atherosclerotic Cardiovascular Disease: SURPASS-CVOT Design and Baseline Characteristics https://pubmed.ncbi.nlm.nih.gov/37758044/

Coordinated Care to Optimize Cardiovascular Preventive Therapies in Type 2 Diabetes: A Randomized Clinical Trial https://pubmed.ncbi.nlm.nih.gov/36877177/

Join Drs Nihar Desai and Jay Udell as they discuss the role of SGLT2 inhibitors in the treatment of cardiorenal metabolic syndrome.

Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/999841. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Effects of SGLT2 Inhibitors on Kidney and Cardiovascular Function https://pubmed.ncbi.nlm.nih.gov/33197224/

Study to Evaluate the Effect of Empagliflozin on Hospitalization for Heart Failure and Mortality in Patients With Acute Myocardial Infarction - EMPACT-MI https://www.acc.org/Latest-in-Cardiology/Clinical-Trials/2024/04/05/03/00/empact-mi

The Bark Giving Diabetes Therapy Some Bite: The SGLT Inhibitors https://pubmed.ncbi.nlm.nih.gov/30132029/

Effects of Dapagliflozin on Development and Progression of Kidney Disease in Patients With Type 2 Diabetes: An Analysis From the DECLARE-TIMI 58 Randomized Trial https://pubmed.ncbi.nlm.nih.gov/31196815/

Thiazolidinediones and Heart Failure: A Teleo-Analysis https://pubmed.ncbi.nlm.nih.gov/17536074/

Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes https://pubmed.ncbi.nlm.nih.gov/26378978/

Sotagliflozin in Patients With Diabetes and Recent Worsening Heart Failure https://pubmed.ncbi.nlm.nih.gov/33200892/

Effect of Empagliflozin on Heart Failure Outcomes After Acute Myocardial Infarction: Insights From the EMPACT-MI Trial https://pubmed.ncbi.nlm.nih.gov/38581389/

Effects of an Angiotensin-Converting-Enzyme Inhibitor, Ramipril, on Cardiovascular Events in High-Risk Patients https://pubmed.ncbi.nlm.nih.gov/10639539/

Join Drs Nihar Desai and Erica Spatz as they discuss the critical importance of social determinants of health in preventing and managing cardiorenal conditions.

Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/999840. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Cardiovascular-Kidney-Metabolic (CKM) Syndrome: A State-of-the-Art Review https://pubmed.ncbi.nlm.nih.gov/38103820/

What Is a Social Determinant of Health? Back to Basics https://pubmed.ncbi.nlm.nih.gov/34162174/

Multi-Ethnic Study of Atherosclerosis (MESA): JACC Focus Seminar 5/8 https://pubmed.ncbi.nlm.nih.gov/34167645/

What to Know About PREVENT, the AHA's New Cardiovascular Disease Risk Calculator https://pubmed.ncbi.nlm.nih.gov/38150239/

Accountable Health Communities Model https://www.cms.gov/priorities/innovation/innovation-models/ahcm

Racial and Ethnic Approaches to Community Health (REACH) https://www.cdc.gov/reach/php/about/index.html

Join Drs Nihar Desai and Chiadi Ndumele as they define and discuss cardiorenal metabolic syndrome, a chronic health condition with the potential to impact up to 90% of the US population.

Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/999839. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Cardiovascular-Kidney-Metabolic Health: A Presidential Advisory From the American Heart Association https://pubmed.ncbi.nlm.nih.gov/37807924/

American Heart Association PREVENTTM Online Calculator https://professional.heart.org/en/guidelines-and-statements/prevent-calculator

Prevalence of Cardiovascular-Kidney-Metabolic Syndrome Stages in US Adults, 2011-2020 https://pubmed.ncbi.nlm.nih.gov/38717747/

2013 ACC/AHA Guideline on the Assessment of Cardiovascular Risk: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines https://pubmed.ncbi.nlm.nih.gov/24222018/

Renoprotection With SGLT2 Inhibitors in Type 2 Diabetes Over a Spectrum of Cardiovascular and Renal Risk https://pubmed.ncbi.nlm.nih.gov/33222693/

Cardiovascular and Kidney Outcomes With Finerenone in Patients With Type 2 Diabetes and Chronic Kidney Disease: The FIDELITY Pooled Analysis https://pubmed.ncbi.nlm.nih.gov/35023547/

Study to Evaluate the Efficacy (Effect on Disease) and Safety of Finerenone on Morbidity (Events Indicating Disease Worsening) & Mortality (Death Rate) in Participants With Heart Failure and Left Ventricular Ejection Fraction (Proportion of Blood Expelled Per Heart Stroke) Greater or Equal to 40% (FINEARTS-HF) https://classic.clinicaltrials.gov/ct2/show/NCT04435626

Novo Nordisk Will Stop the Once-Weekly Injectable Semaglutide Kidney Outcomes Trial, FLOW, Based on Interim Analysis https://www.novonordisk.com/news-and-media/news-and-ir-materials/news-details.html?id=166327

Long-Term Kidney Outcomes of Semaglutide in Obesity and Cardiovascular Disease in the SELECT Trial https://pubmed.ncbi.nlm.nih.gov/38796653/