In this episode, host Dr Michael Saag speaks with Dr Paul Volberding, founder of the world's first dedicated HIV outpatient clinic, about their clinical experience treating HIV from the early days of the pandemic until now. They discuss the medical breakthroughs that they have seen over the years and how the history of HIV treatment directly informs treatment today.

Relevant disclosures can be found with the episode show notes on Medscape.com (https://www.medscape.com/viewarticle/963236). The topics and discussions are planned, produced, and reviewed independently of our advertiser. This podcast is intended only for US healthcare professionals.

Resources

Kaposi sarcoma clinical presentation https://emedicine.medscape.com/article/279734-clinical

Lymphadenopathy: endpoint or prodrome? Update of a 24-month prospective study https://pubmed.ncbi.nlm.nih.gov/6335951/

Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS) https://pubmed.ncbi.nlm.nih.gov/6189183/

The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial https://pubmed.ncbi.nlm.nih.gov/3299089/

The history of PCR http://siarchives.si.edu/research/videohistory_catalog9577.html

History of HAART -- the true story of how effective multi-drug therapy was developed for treatment of HIV disease https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1716971/

Dr Michael Saag and Dr Aadia Rana discuss best practices that providers can implement to prevent the spread of HIV in their local communities and connect HIV-positive patients to lifesaving care.

Relevant disclosures can be found with the episode show notes on Medscape.com (https://www.medscape.com/viewarticle/963237). The topics and discussions are planned, produced, and reviewed independently of our advertiser. This podcast is intended only for US healthcare professionals.

Resources

90-90-90 Treatment for all https://www.unaids.org/en/resources/909090

Too Many People Living with HIV in the U.S. Don't Know It https://www.hiv.gov/blog/too-many-people-living-hiv-us-don-t-know-it

CDC: HIV Testing Guidelines https://www.cdc.gov/hiv/testing/index.html

The science is clear: with HIV, undetectable equals untransmittable https://www.nih.gov/news-events/news-releases/science-clear-hiv-undetectable-equals-untransmittable

Initiating Antiretroviral Therapy for HIV at a Patient's First Clinic Visit: The RapIT Randomized Controlled Trial https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1002015

Implementation of an Immediate HIV Treatment Initiation Program in a Public/Academic Medical Center in the U.S. South: The Miami Test and Treat Rapid Response Program https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934174/

Development of a Citywide Rapid Antiretroviral Therapy Initiative in San Francisco https://pubmed.ncbi.nlm.nih.gov/34686290/

Immediate Initiation of HIV Treatment https://www1.nyc.gov/site/doh/providers/health-topics/aids-hiv-immediate-antiretroviral-therapy.page

Drs Michael Saag and Constance Benson discuss antiretroviral therapy, maintenance, and switching.

Relevant disclosures can be found with the episode show notes on Medscape.com (https://www.medscape.com/viewarticle/963238). The topics and discussions are planned, produced, and reviewed independently of our advertiser. This podcast is intended only for US healthcare professionals.

Resources

Preexposure Prophylaxis for the Prevention of HIV Infection in the United States – 2021 Update https://www.cdc.gov/hiv/pdf/risk/prep/cdc-hiv-prep-guidelines-2021.pdf

AIDS Clinical Trials Group https://actgnetwork.org/

Clarithromycin Therapy for Bacteremic Mycobacterium Avium Complex Disease https://www.acpjournals.org/doi/10.7326/0003-4819-121-12-199412150-00001?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed

UC San Diego Medical Center https://healthlocations.ucsd.edu/san-diego/200-w.-arbor-drive-hospital

Highlights from the Ryan White Clinical Conference https://www.hiv.gov/blog/long-acting-injectables-hold-promise-maintaining-viral-suppression-and-preventing-hiv

Clinical Effectiveness of Integrase Strand Transfer Inhibitor–Based Antiretroviral Regimens Among Adults With Human Immunodeficiency Virus: A Collaboration of Cohort Studies in the United States and Canada https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492356/

Key Considerations and Recommendations for Early (Acute and Recent) HIV Infection https://clinicalinfo.hiv.gov/en/guidelines/hiv-clinical-guidelines-adult-and-adolescent-arv/early-acute-and-recent-hiv-infection?view=full

Rising Rates of Recent Preexposure Prophylaxis Exposure Among Men Having Sex with Men Newly Diagnosed With HIV: Antiviral Resistance Patterns and Treatment Outcomes https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876422/

Long-acting Cabotegravir Plus Rilpivirine for Treatment in Adults With HIV-1 Infection: 96-week Results of the Randomised, Open-Label, Phase 3 FLAIR Study https://linkinghub.elsevier.com/retrieve/pii/S2352-3018(20)30340-4