Drs Sparks and Kumar go behind the scenes and discuss the preparation, surgery, and outcome of the pig-to-human kidney xenotransplantation at The University of Alabama.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/971886). The topics and discussions are planned, produced, and reviewed independently of advertiser. This podcast is intended only for US healthcare professionals.

Resources

The Advancing American Kidney Health Initiative https://www.kidney.org/advocacy/advancing-american-kidney-health-initiative

Nearly 106,000 U.S. Residents Are Waiting for a Lifesaving Transplant https://www.washingtonpost.com/health/2022/05/24/organ-transplant-waiting-list-numbers/

UNOS Patients on the Waiting List vs. Transplants Performed by Organ (2021) https://www.organdonor.gov/learn/organ-donation-statistics/detailed-description#fig1

First Clinical-Grade Porcine Kidney Xenotransplant Using a Human Decedent Model https://onlinelibrary.wiley.com/doi/abs/10.1111/ajt.16930

Mathieu Jaboulay's (1860–1913) Contribution to Xenotransplantation https://onlinelibrary.wiley.com/doi/10.1111/xen.12765

Alexis Carrel - Biographical https://www.nobelprize.org/prizes/medicine/1912/carrel/biographical/

5 Things to Know About CRISPR https://www.medscape.com/viewarticle/899354

Organ Donation and Transplantation Alliance https://www.organdonationalliance.org/

When Pigs Fly https://onlinelibrary.wiley.com/doi/10.1111/ajt.16963

C4d Staining in Renal Allograft Biopsies With Early Acute Rejection and Subsequent Clinical Outcome https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087790/

Results of Two Cases of Pig-to-Human Kidney Xenotransplantation https://www.nejm.org/doi/10.1056/NEJMoa2120238

University of Maryland School of Medicine Faculty Scientists and Clinicians Perform Historic First Successful Transplant of Porcine Heart Into Adult Human With End-stage Heart Disease https://www.medschool.umaryland.edu/news/2022/University-of-Maryland-School-of-Medicine-Faculty-Scientists-and-Clinicians-Perform-Historic-First-Successful-Transplant-of-Porcine-Heart-into-Adult-Human-with-End-Stage-Heart-Disease.html

Thomas E. Starzl Transplantation Institute http://www.stiresearch.health.pitt.edu/about