エピソード

  • STH - E30 Dr. Kliment Verba - Cryo-EM & COVID-19 virus receptor traps
    2023/04/24

    Dr. Kliment Verba is an Assistant Professor at the Quantitative Biosciences Institute (QBI) and Department of Cellular and Molecular Pharmacology at UCSF. Dr. Verba uses biophysical methods such as cryo-EM (cryogenic electron microscopy) to study structural biology and elucidate how proteins look in 3D, down to atomic details. His work spans topics ranging from cancer biology to virology, including recent work on the COVID-19 virus, which we discuss in this episode. For more information, visit Dr. Verba's profile and the QBI website.

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    1 時間
  • STH - E29 Dr. Derek Lowe - Blogging & Drug Discovery
    2022/12/19

    Dr. Derek Lowe is a medicinal chemist, author, and blogger. He is currently Director in Chemical Biology and Therapeutics at the Novartis Institutes for Biomedical Research (NIBR). Dr. Lowe’s work in drug discovery has spanned multiple decades with tenures at Schering-Plough, Bayer, and Vertex Pharmaceuticals. In addition to his industry work, Dr. Lowe authors a popular blog covering topics in drug discovery; check it out here: In the Pipeline. 

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    42 分
  • STH - E28 Dr. Eric Wang Returns - Leukemia & Therapy Resistance
    2022/06/29

    Dr. Eric Wang is an Assistant Professor at The Jackson Laboratory (JAX) for Genomic Medicine. Dr. Wang's work has uncovered new therapeutic vulnerabilities in RNA-binding protein networks in leukemia through the use of genomic screening approaches, which we discuss in this episode. His lab investigates therapy resistance in cancer, with a focus on leukemias. For more information, visit his lab page: Wang Lab

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    36 分
  • STH - E27 Dr. Mario Suva
    2021/02/18

    Dr. Mario Suva is an Associate Professor of Pathology at Harvard Medical School and Massachusetts General Hospital, is affiliated with the Neuro-Oncology program at Dana-Farber/Harvard Cancer Center, and is a member of the Broad Institute of MIT and Harvard. Dr. Suva's lab focuses on the biology of brain tumors, using single-cell technologies to dissect cellular heterogeneity and plasticity. Furthermore, recent work from his lab describes an atlas of glioma-infiltrating T cells, which we discuss in this episode. For more information, visit his lab page: Suva Lab

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    48 分
  • STH - E26 Dr. Mariella G. Filbin
    2019/09/13

    Dr. Mariella G. Filbin is an Attending Physician of Pediatric Oncology at Dana-Farber Cancer Institute, an Assistant Professor of Pediatrics at Harvard Medical School, and an Associate Member of the Broad Institute of Harvard and MIT. The Filbin Lab focuses its efforts on studying pediatric brain tumors, particularly lethal high-grade gliomas, including diffuse intrinsic pontine glioma (DIPG) and malignant embryonal brain tumors. Dr. Filbin's approach to understanding these tumors involves genomic technologies such as single cell RNA sequencing, which we discuss in this episode. For more information, visit her lab page: Filbin Lab

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    36 分
  • STH - E25 Laura Valente
    2019/06/26

    Laura Valente is a PhD student in the Department of Pathology at Duke University School of Medicine. She conducts research in the lab of Dr. Anthony Filiano, who is a faculty member in the Neurosurgery, Immunology, and Pathology departments at Duke. Laura's work focuses on developing mouse models of thymus transplants done in patients to understand the underlying mechanisms of thymus transplant efficacy. Recently, Laura took part in a science advocacy workshop called Catalyzing Advocacy in Science and Engineering (CASE), held by the American Association for the Advancement of Science (AAAS). In this episode, we discuss Laura's research and her recent crash course in science advocacy. For more information on Laura's research, please visit the Filiano Lab website. For more information on the CASE workshop, please visit the AAAS CASE website.

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    28 分
  • STH - E24 Dr. Kris Wood
    2018/04/20

    Dr. Kris Wood is an Assistant Professor in the Department of Pharmacology and Cancer Biology and the Department of Biomedical Engineering at Duke University. The Wood Lab utilizes functional genomics approaches to uncover targetable vulnerabilities in different types of human cancers. Much of this work is driven by investigation of the complex signaling networks that drive tumor formation and progression. Dr. Wood's research also leads to identification of combinatorial treatment strategies for cancers that evolve to develop resistance to monotherapies. For more information visit his lab page: Wood Lab

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    39 分
  • STH - E23 Dr. Herman Staats
    2018/03/01

    Dr. Herman Staats is a Professor and the Vice Chair for Research in the Department of Pathology at Duke University School of Medicine. Broadly, the Staats Lab focuses on vaccines and immunity. The lab's main projects include identifying and characterizing new adjuvants, and optimizing nasal immunization for use in humans. An adjuvant is any substance co-administered with a vaccine to enhance the immune response to the vaccine, and we discuss this topic in detail in this episode. For more information visit his lab page: Staats Lab

     

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    27 分