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In today’s episode of The Optimal Protein Podcast, we uncover a groundbreaking discovery about LEAP2, a newly identified hormone that plays a key role in hunger regulation, ketone production, and appetite suppression.

We are breaking down a 2022 study published in Endocrinology titled b-Hydroxybutyrate Suppresses Hepatic Production of the Ghrelin Receptor Antagonist LEAP2 (PubMed link).

This research reveals how ketones specifically b-hydroxybutyrate (BHB) interact with LEAP2 and the hunger hormone ghrelin, explaining why high-protein, low-carb, and ketogenic diets naturally reduce appetite and support fat loss.

If you’ve ever wondered why a high-protein diet helps you stay full longer while promoting fat-burning, this episode explains the new science behind it!

Key Takeaways

-What is LEAP2? The newly discovered hormone that regulates hunger and ketone metabolism.

-How high-protein diets generate ketones, even without high fat intake.

-The role of BHB in appetite suppression.

-How LEAP2 interacts with ghrelin, the hunger hormone.

-Why hunger may temporarily increase when starting ketosis but decrease over time.

-How this research explains the long-term appetite-suppressing effects of ketogenic and high-protein diets.

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The content provided in this podcast is for informational purposes only and should not be construed as medical advice. Consult with a healthcare professional before making significant changes to your diet or exercise regimen.