📢 207,255 cases of syphilis in the United States in 2022; that is an 80% increase since 2018 per the Centers for Disease Control and Prevention (CDC). 1.6 million cases of chlamydia, 650 reports of gonorrohea, and to add to those syphilis numbers, 3800 cases of syphilis among newborns. What are we doing? Really, we've got to do better in removing the stigma behind STIs and make treatment more accessible. Website: www.pharmwyze.comShop: www.pharmwyze.com/shop Social Links: https://links.pharmwyze.com DrugQueryInbox Request: https://pharmwyze.hopp.to/drugqueryinbox Streaming Platforms: https://pharmwyze.hopp.to/podstreams Patreon: https://patreon.com/PHARMWYZE Paypal Donation: https://pharmwyze.hopp.to/paypaldonate PHARMWYZE SITREP Newsletter: https://www.pharmwyze.com/sitrepnewsletter Harris, E. JAMA. 2023 May 16;329(19):1633. Tuddenham S, Hamill MM, Ghanem KG. JAMA. 2022 Jan 11;327(2):161-172. Korkowsi KA, Bachmann LH, Chan PA, et al. MMWR Recomm Rep. 2021 Jul 23;70(4):1-187.s Forrestel AK, Kovarik CL, Katz KA. J Am Acad Dermatol. 2020 Jan;82(1):17-28. CDC Links https://www.cdc.gov/std/syphilis/default.htm https://www.cdc.gov/tuskegee/timeline.htm#print Not medical advice. Educational purposes only. No relationships to report. #medicalschool #clinicalpearls #nursingschool #pharmacyschool #medicaleducation #pharmacist #pharmwyze #pharmfax #criticalcare #emergencymedicine #studentpharmacist #nursingstudent #medicalstudent #pharmacy #medicine #nursing #meded #shorts #rxshorts #medigram #medshed #foamed #emrx #pharmacology #pharmacokinetics #cardiology #antibiotics #neurology #patientcase #clinicalmedicine #clinicalpharmacy

🌟 Drug Query Inbox Episode 4 - Patient Case Post Recap - Role of clindamycin for necrotizing fasciitis? - Changing anticonvulsant therapy? - Benefit of tenecteplase over alteplase for massive PE? Welcome to PHARMWYZE! Clinical pharmacotherapy content made for learners of all medicine backgrounds. Thanks for joining my video series, #DRUGQUERYINBOX. I often get questions in the comments on my social media platforms, which I'll compile into weekly to biweekly videos. Website: www.pharmwyze.com Shop: www.pharmwyze.com/shop Social Links: https://links.pharmwyze.com DrugQueryInbox Request: https://pharmwyze.hopp.to/drugqueryinbox Streaming Platforms: https://pharmwyze.hopp.to/podstreams Patreon: https://patreon.com/PHARMWYZE Paypal Donation: https://pharmwyze.hopp.to/paypaldonate PHARMWYZE SITREP Newsletter: https://www.pharmwyze.com/sitrepnewsletter References Powers WJ, Rabinstein AA, Ackerson T, et al. Stroke. 2019 Dec;50(12):e344-e418. Korkowsi KA, Bachmann LH, Chan PA, et al. MMWR Recomm Rep. 2021 Jul 23;70(4):1-187. Pantel P, Peterson CD. Ann Emerg Med. 1980 Nov;9(11):588-90. Javaudin F, Lascarrou JP, Bastard QL, et al. Chest. 2019 Dec;156(6):1167-1175. Batchelor R, Liu DH, Bloom J, et al. Catheter Cardiovasc Interv. 2020 Jul;96(1):76-88. Bosson N, Isakson B, Morgan JA, et al. Prehosp Emerg Care. 2019 Sep-Oct;23(5):603-611. Not medical advice. Educational purposes only. No relationships to report. #medicalschool #clinicalpearls #nursingschool #pharmacyschool #medicaleducation #pharmacist #pharmwyze #pharmfax #criticalcare #emergencymedicine #studentpharmacist #nursingstudent #medicalstudent #pharmacy #medicine #nursing #meded #shorts #rxshorts #medigram #medshed #foamed #emrx #pharmacology #pharmacokinetics #cardiology #antibiotics #neurology #patientcase #clinicalmedicine #clinicalpharmacy

For this episode, we did something different than prior videos. There was a request from viewers on Instagram for a week of MEDIGRAM patient cases, so I've made a review of those post. Also, I included viewer questions that came from the comments! Website: www.pharmwyze.com Shop: www.pharmwyze.com/shop Social Media: linktr.ee/pharmwyze Patreon: https://patreon.com/PHARMWYZE Shopify: wearfarmd.myshopify.com Etsy: https://pharmwyze.etsy.com PHARMWYZE SITREP Newsletter: https://www.pharmwyze.com/sitrepnewsletter References Evans L, Rhodes A, Alhazzani W, et al. Intensive Care Med. 2021 Nov;47(11):1181-1247. Umar Z, Ul Rasool MH, Muhammad S, et al. Cureus. 2023 Jan 12;15(1):e33695. Heindenreich PA, Bozjurt B, Aguilar D, et al. Circulation. 2022 May 3;145(18):e895-e1032. Shaker MS, Wallace DV, Golden DB, et al. J Allergy Clin Immunol. 2020 Apr;145(4):1082-1123. Hoy SM. Drugs. 2018 Oct;78(15):1605-1613. Panchal AR, Bartos JA, Cabanas JG, et al. Circulation. 2020 Oct 20;142(16_suppl_2):S366-S468. Not medical advice. Educational purposes only. No relationships to report.

🦴 Where does ceftriaxone fit in that arsenal of bug juice for that bone sticking out? How do we classify and grade open fractures? Why do guidelines recommend cefazolin and gentamicin for extensive injuries? Hello there, Pharmers and Friends, Mark with PHARMWYZE. I'm a board certified emergency medicine pharmacist. I make clinical pharmacotherapy content on the social medias. Thanks for joining me on the Code Blue Debrief: A Clinical Pharmacotherapy YouTube & Podcast Series. We discuss emergency medicine and critical care pharmacology and disease state management. Make sure to stop by my website at www.pharmwyze.com, or visit linktr.ee/pharmwyze for my SM accounts. Website: www.pharmwyze.com Shop: www.pharmwyze.com/shop Patreon: https://patreon.com/PHARMWYZE Paypal Donation: https://www.paypal.com/donate/?hosted_button_id=PTNLSD4G5X6BA Social Media: linktr.ee/pharmwyze PHARMWYZE SITREP Newsletter: https://www.pharmwyze.com/pharmacotherapy-newsletter AtlasVPN: http://tinyurl.com/8tahadc7 Not medical advice. Educational purposes only. No relationships to report. References Hoff WS, Bonadies JA, Cachecho R, Dorlac WC. J Trauma. 2011 Mar;70(3):751-4. Rodriguez L, Jung HS, Goulet JA, et al. J Trauma Acute Care Surg. 2014 Sep;77(3). Vasenius J, Tulikoura I, Vainionpaa S, Rokkanen P. Ann Chir Gynaecol. 1998;87(3):224-8. Bankhead-Kendall B, Gutierrez T, Murry J, et al. Eur J Trauma Emerg Surg. 2019 Feb;45(1):125-129. #pharmacist #pharmwyze #pharmfax #criticalcare #emergencymedicine #studentpharmacist #nursingstudent #medicalstudent #pharmacy #medicine #nursing #meded #shorts #rxshorts #medigram #thelab #medshed #foamed #emrx #pharmacology #pharmacokinetics #pharmacodynamics #cardiology #neurology #infectiousdisease #mechanism #mechanismofaction #moa #drugs #ketamine #propofol #etomidate #fentanyl #rxshorts #massivetransfusion #ems #emergency #antibiotics #metabolism #antipsychotics #drugs

Up to 53% of patients will develop chronic epilepsy even with seizure prophylaxis in the setting of traumatic brain injuries. How do TBIs even cause seizures? When should we give seizure prophylaxis for TBIs? What anticonvulsants are considered for this indication? Hello there, Pharmers and Friends, Mark with PHARMWYZE. I'm a board certified emergency medicine pharmacist. I make clinical pharmacotherapy content on the social medias. Thanks for joining me on the Code Blue Debrief: A Clinical Pharmacotherapy YouTube & Podcast Series. We discuss emergency medicine and critical care pharmacology and disease state management. Make sure to stop by my website at www.pharmwyze.com, or visit linktr.ee/pharmwyze for my SM accounts. Website: www.pharmwyze.com Shop: www.pharmwyze.com/shop Patreon: https://patreon.com/PHARMWYZE Paypal Donation: https://www.paypal.com/donate/?hosted_button_id=PTNLSD4G5X6BA Social Media: linktr.ee/pharmwyze PHARMWYZE SITREP Newsletter: https://www.pharmwyze.com/pharmacotherapy-newsletter AtlasVPN: http://tinyurl.com/8tahadc7 Not medical advice. Educational purposes only. No relationships to report. References Ohman K, Kram B, Schultheis J et al. Neurocrit Care. 2023 Apr;38(2):345-355. Carney et al. Neurosurgery. 2017 Jan 1;80(1):6-15. Lucke-Wold et al. Seizure. 2015 Dec;33:13-23. DJohn J, Ibrahim R, Patel P, et al. Cureus. 2020 Jul; 12(7): e9117. #pharmacist #pharmwyze #pharmfax #criticalcare #emergencymedicine #studentpharmacist #nursingstudent #medicalstudent #pharmacy #medicine #nursing #meded #shorts #rxshorts #medigram #thelab #medshed #foamed #emrx #pharmacology #pharmacokinetics #cardiology #neurology #infectiousdisease #mechanism #mechanismofaction #moa #drugs #ketamine #propofol #etomidate #fentanyl #calcium #mtp #massivetransfusion #ems #emergency #antibiotics #metabolism #antipsychotics #drugs

Having a burning sensation down there after a weekend of high-risky behavior? Which antibiotics are used for chlamydia and gonorrhea? What options are available for pregnant women or true allergies for these sexually transmitted diseases? Chlamydia and Gonorrhea are the two most common sexually transmitted infections in the United States. There was a fairly recent update to the CDC STI Guidelines, tune in as we'll discuss the preferred agents. Hello there, Pharmers and Friends, Mark with PHARMWYZE. I'm a board certified emergency medicine pharmacist. I make clinical pharmacotherapy content on the social medias. Thanks for joining me on the Code Blue Debrief: A Clinical Pharmacotherapy YouTube & Podcast Series. We discuss emergency medicine and critical care pharmacology and disease state management. Make sure to stop by my website at www.pharmwyze.com, or visit linktr.ee/pharmwyze for my SM accounts. Website: www.pharmwyze.com Shop: www.pharmwyze.com/shop Patreon: https://patreon.com/PHARMWYZE Paypal Donation: https://www.paypal.com/donate/?hosted_button_id=PTNLSD4G5X6BA Social Media: linktr.ee/pharmwyze PHARMWYZE SITREP Newsletter: https://www.pharmwyze.com/pharmacotherapy-newsletter AtlasVPN: http://tinyurl.com/8tahadc7 Not medical advice. Educational purposes only. No relationships to report. References Dukers-Muijrers N., Wolffs P.F.G., De Vries H., et. al.: Treatment Effectiveness of Azithromycin and Doxycycline in Uncomplicated Rectal and Vaginal Chlamydia trachomatis Infections in Women: A Multicenter Observational Study (FemCure). Clin Infect Dis 2019; 69: pp. 1946-1954. Dombrowski J.C., Wierzbicki M.R., Newman L.M., et. al.: Doxycycline Versus Azithromycin for the Treatment of Rectal Chlamydia in Men Who Have Sex With Men: A Randomized Controlled Trial. Clin Infect Dis 2021; 73: pp. 824-831. Dutra K, Lazenby G. An Update on Gonorrhea and Chlamydia. Obstet Gynecol Clin North Am. 2023 Jun;50(2):299-310. Workowski KA, Bachmann LH, Chan PA, et al. MMWR Recomm Rep. 2021 Jul 23;70(4):1-187. #pharmacist #pharmwyze #pharmfax #criticalcare #emergencymedicine #studentpharmacist #nursingstudent #medicalstudent #pharmacy #medicine #nursing #meded #shorts #rxshorts #medigram #thelab #medshed #foamed #emrx #pharmacology #pharmacokinetics #cardiology #neurology #infectiousdisease #mechanism #mechanismofaction #moa #drugs #ketamine #propofol #etomidate #fentanyl #calcium #mtp #massivetransfusion #ems #emergency #antibiotics #metabolism #antipsychotics #drugs

Make sure to reel and deal those calcium salts during Massive Transfusion Protocol (MTP). Calcium salts are arguably the most important pharmacologic agent during MTP. Hello there, Pharmers and Friends, Mark with PHARMWYZE. I'm a board certified emergency medicine pharmacist. I make clinical pharmacotherapy content on the social medias. Thanks for joining me on the Code Blue Debrief: A Clinical Pharmacotherapy YouTube & Podcast Series. We discuss emergency medicine and critical care pharmacology and disease state management. Make sure to stop by my website at www.pharmwyze.com, or visit linktr.ee/pharmwyze for my SM accounts. Website: www.pharmwyze.com Shop: www.pharmwyze.com/shop Patreon: https://patreon.com/PHARMWYZE Paypal Donation: https://www.paypal.com/donate/?hosted_button_id=PTNLSD4G5X6BA Social Media: linktr.ee/pharmwyze PHARMWYZE SITREP Newsletter: https://www.pharmwyze.com/pharmacotherapy-newsletter Not medical advice. Educational purposes only. No relationships to report. References Meneses E, Boneva D, McKenney M, Elkbuli A. Massive transfusion protocol in adult trauma population. Am J Emerg Med. 2020 Dec;38(12):2661-2666. Wray JP, Bridwell RE, Schauer SG, Schakelford SA et al. The diamond of death: Hypocalcemia in trauma and resuscitation. Am J Emerg Med. 2021 Mar:41:104-109. Helsoot D, Fitzgerald M, Lefering R et al. Trauma-induced disturbances in ionized calcium levels correlate parabolically with coagulopathy, transfusion, and mortality: a multicentre cohort analysis from the TraumaRegister DGU®.Crit Care. 2023 Jul 6;27(1):267. Vasudeva M, Mathew JK, Groombridge C et al. Hypocalcemia in trauma patients: A systematic review. J Trauma Acute Care Surg. 2021 Feb; 90(2): 396–402. Robinson A, Rech MA, DeChristopher PJ et al. Defining the optimal calcium repletion dosing in patients requiring activation of massive transfusion protocol. Am J Emerg Med. 2023 Aug:70:96-100. Borowko R, Vignon PO, Lutz N. et al. The lethal triad of hemorrhage. Rev Infirm. 2021 Aug-Sep;70(273):16-18. #pharmacist #pharmwyze #pharmfax #criticalcare #emergencymedicine #studentpharmacist #nursingstudent #medicalstudent #pharmacy #medicine #nursing #meded #shorts #rxshorts #medigram #thelab #medshed #foamed #emrx #pharmacology #pharmacokinetics #cardiology #neurology #infectiousdisease #mechanism #mechanismofaction #moa #drugs #ketamine #propofol #etomidate #fentanyl #calcium #mtp #massivetransfusion #ems #emergency #antibiotics #metabolism

👾 Physostigmine is a reversal agent for anticholinergic toxicities. By inhibiting acetylcholinesterase, increased acetylcholine becomes available at the synapses. It is an excellent drug to reverse antimuscurinic poisonings. Unfortuanetely, it has a negative stigma from prior case reports associated with TCA deaths. The Akorn manufacturer went bankrupt recently, leaving the US without product available for the market. Recently, the FDA announced they would allow temporary importation from a company in Germany. Hello there, Pharmers and Friends, Mark with PHARMWYZE. I'm a board certified emergency medicine pharmacist. I make clinical pharmacotherapy content on the social medias. Thanks for joining me on the Code Blue Debrief: A Clinical Pharmacotherapy YouTube & Podcast Series. Make sure to hit the follow, subscribe, and notification bell as we get into the episode's topic. For this episode, we'll be discussing anticholinergic toxicity and the use of physostigmine. Make sure to stop by my website at www.pharmwyze.com, or visit linktr.ee/pharmwyze for my SM accounts. Website: www.pharmwyze.com Social Media: linktr.ee/pharmwyze PHARMWYZE SITREP Newsletter: https://www.pharmwyze.com/pharmacotherapy-newsletter Shop: www.pharmwyze.com/shop References Newton RW. JAMA . 1975 Mar 3;231(9):941-3. Pentel P, Peterson CD. Ann Emerg Med . 1980 Nov;9(11):588-90. Wang GS et al. Clin Toxicol (Phila). 2021 Aug;59(8):698-704. Watkins JW et al. J Med Toxicol. 2015 Jun;11(2):179-84. Fratta KA, Ginder M, Haggerty DA. The Journal of Emergency Medicine, Vol. 65, No. 4, pp. e366–e368, 2023 McCoy CE, Honda R. J Educ Teach Emerg Med. 2023 Jan 31;8(1):S25-S47. Elkhazeen A et al. J Forensic Sci . 2023 Jan;68(1):339-342. Nishtala PS, Salahudeen SJ, Hilmer SN. Expert Opin Drug Saf . 2016 Jun;15(6):753-68. https://www.fda.gov/drugs/drug-shortages/october-31-2023-temporary-importation-available-physostigmine-injection https://www.ashp.org/drug-shortages/current-shortages/drug-shortage-detail.aspx?id=721&loginreturnUrl=SSOCheckOnly