検索キーワード： 遺伝子

19世紀後半にメンデルが発見した遺伝の法則とダーウィンの進化論が出会い、遺伝学は歩み始めた。そして今、人類はゲノム編集の時代を迎えている。遺伝子が握る人類の運命とは？　ピュリッツァー賞受賞の医学者が自らの家系に潜む精神疾患の悲劇を織り交ぜながら、圧倒的なストーリーテリングで紡ぐ遺伝子全史

2000年代初頭、人間の全遺伝情報=ヒトゲノムがついに解読された。その後まもなく、山中伸弥らがiPS細胞(人工多能性幹細胞)の作製に成功。そして今、ジェニファー・ダウドナらが開発した新技術「CRISPR-Cas9」により、人類は「ゲノム編集」の時代を迎えている。自らの設計図を望み通りに書き換えられるようになったとき、人間の条件はどう変わるのか? 科学と倫理のせめぎ合いを圧倒的なストーリーテリングで描く傑作。

The Gene is the story of one of the most powerful and dangerous ideas in our history, from best-selling, prize-winning author Siddhartha Mukherjee. Spanning the globe and several centuries, The Gene is the story of the quest to decipher the master code that makes and defines humans, that governs our form and function. The story of the gene begins in an obscure Augustinian abbey in Moravia in 1856, where a monk stumbles on the idea of a 'unit of heredity'.

Contrary to conventional wisdom, chronic disease is not genetically predetermined but results from a mismatch between our genes and environment and lifestyle. What we call a "disease" is the outcome of an imbalance in one or more of the seven core physiological processes. Leveraging a lifetime on the cutting edge of research and practice, Dr. Jeffrey S. Bland lays out a road map for good health by helping us understand these processes and the root causes of chronic illness.

From an acclaimed Harvard professor and one of Time’s most influential people, this paradigm-shifting audiobook shows how almost everything we think we know about aging is wrong, offers a front-row seat to the amazing global effort to slow, stop, and reverse aging, and calls listeners to consider a future where aging can be treated.

The extraordinary Siddhartha Mukherjee has written a biography of the gene as deft, brilliant, and illuminating as his extraordinarily successful biography of cancer. Weaving science, social history, and personal narrative to tell us the story of one of the most important conceptual breakthroughs of modern times, Mukherjee animates the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices.

In the early 1800s, a century before there was any concept of the gene, physicians in insane asylums began to record causes of madness in their admission books. Almost from the beginning, they pointed to heredity as the most important of these causes. As doctors and state officials steadily lost faith in the capacity of asylum care to stem the terrible increase of insanity, they began emphasizing the need to curb the reproduction of the insane. They became obsessed with identifying weak or tainted families and anticipating the outcomes of their marriages.

In The Genome Odyssey, Dr. Euan Ashley, Stanford professor of medicine and genetics, brings the breakthroughs of precision medicine to vivid life through the real diagnostic journeys of his patients and the tireless efforts of his fellow doctors and scientists as they hunt to prevent, predict, and beat disease.

A new gene editing technology, invented just seven years ago, has turned humanity into gods. Enabling us to manipulate the genes in virtually any organism with exquisite precision, CRISPR has given scientists a degree of control that was undreamt of even in science fiction. But CRISPR is just the latest, giant leap in a long journey to master genetics. The Genetic Age shows the astonishing, world-changing potential of the new genetics and the possible threats it poses, sifting between fantasy and the reality when it comes to both benefits and dangers.

Ancestor Trouble is one writer’s attempt to use genealogy - a once-niche hobby that has grown into a multi-billion-dollar industry - to expose the secrets and contradictions of her own ancestors, and to argue for the transformational possibilities that reckoning with our ancestors offers all of us.

In November 2018, the world was shocked to learn that two babies had been born in China with DNA edited while they were embryos - as dramatic a development in genetics as the cloning of Dolly the sheep was in 1996. In this book, Hank Greely, a leading authority on law and genetics, tells the fascinating story of this human experiment and its consequences. Greely explains what Chinese scientist He Jiankui did, how he did it, and how the public and other scientists learned about and reacted to this unprecedented genetic intervention.

Since the discovery of DNA, scientists have believed that genes are fixed entities that cannot be changed by environment - we inherit them, pass them on to our children and take them with us when we die. Professor Tim Spector reveals how the latest genetic research and his own pioneering studies on epigenetics are rewriting everything we thought we knew about genes, identity and evolution.

Po Bronson and Arvind Gupta, venture capitalists from Silicon Valley, take everyday news headlines and decode them, leading us on a journey through their unique and highly entertaining view of the world. Each chapter is prefaced with a real-world headline from today's chaotic news cycle: dying bees. Rogue planets. Beyond Meat. Glaciers melting. Bronson and Gupta decipher what's really going on behind these headlines, and why.

Isabel Stenzel Byrnes and Anabel Stenzel tell of their lifelong struggle to pursue normal lives with cystic fibrosis while grappling with the realization that they will die young. Their story reflects the physical and emotional challenges of a particularly aggressive form of CF and tells how the twins' bicultural heritage - Japanese and German - influenced the way they coped with these challenges.

Orphan is about the struggle to save the lives of children who, because of an unlucky roll of the genetic dice, are born with any one of several thousand rare genetic disorders. Many are burdened with diseases that carry mysterious names, some of which you will hear about for the first time in this audiobook, along with compelling stories about the physicians, scientists, and parents who have taken them on.

A scientific and medical revolution has crept up on us, based on study after study, from hundreds of laboratories around the world. It is no longer just a theoretical shift: every one of us will be touched by it, and many of us already have been. The meaning of disease, our understanding of the human body, and crucial decisions about what we all need to know and what choices we make about our health are at stake. Welcome to the new world of personalized medicine.

In The Decision Tree, Thomas Goetz proposes a new strategy for thinking about health, one that applies cutting-edge technology and sound science to put us at the center of the equation. An individuals Decision Tree begins with genomics, where $400 and a test tube of spit provides a peek at how your DNA influences your health. It taps self-monitoring and collaborative health tools, where iPhone applications and next-generation monitoring gadgets can help individuals successfully change their behavior, once and for all.

Until very recently, if you were to ask most doctors, they would tell you there were only two kinds of medicine: the quack kind, and the evidence-based kind. The former is baseless, and the latter based on the best information human effort could buy. Well, Eric Topol isn't most doctors, and he suggests you entertain the notion of a third kind of medicine, one that will make the evidence-based state-of-the-art stuff look scarcely better than an alchemist trying to animate a homunculus in a jar.

Around 250,000 people have had their genomes sequenced, and scientists expect that number to rise to one billion by 2025. Professor Steven J. Heine argues that the first thing we will do on receiving our DNA test results is to misinterpret them completely. Despite breathless (often lightly researched) media coverage about newly discovered "cancer" or "divorce" or "IQ" genes, the prospect of a DNA test forecasting how your life is going to turn out is vanishingly small.

In Beat the Heart Attack Gene, world-renowned cardiovascular specialists Bradley Bale, MD, and Amy Doneen, ARNP, present a new model for understanding and preventing heart disease. They explain the three different genetic types of cholesterol profiles and tailor treatments for each type, using their cutting-edge Bale/Doneen Method, a simple, comprehensive prevention plan that detects cardiovascular disease (CVD) at early stages.