『Midlife Mayhem』のカバーアート

Midlife Mayhem

Midlife Mayhem

著者： joanne lee cornish
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Welcome to Midlife Mayhem, where we embark on an empowering journey through the world of midlife body composition transformation. In this space, we challenge the misconceptions surrounding aging and redefine what’s possible for those navigating the exhilarating terrain of midlife and beyond. Join me as we explore the science, mindset shifts, and practical strategies that can help you sculpt the body of your dreams, proving that age is no barrier to achieving peak vitality and confidence. Whether you’re seeking to shed excess weight, gain lean muscle, or simply feel more vibrant, this podcast is your trusted companion in the pursuit of a healthier, stronger, and more resilient you. Welcome to a new era of limitless possibilities in midlife body transformation. ”Hi I’m Joanne, and I have been coaching body composition for over 30 years. I’ve worked with household names that you know, and I have worked with thousands of people in my group coaching programs. I was a pro bodybuilder in the 90’s with a top 10 physique in the world, but I only knew how to be in shape and out of shape. That frustration led me on a fascinating path of self-study where I found all the answers I could have asked for and more. But I had to dig for the answers, and I have my own ideas on why those answers are not mainstream and why the weight loss industry fails you, but I will save that for a Midlife Mayhem episode. Author of ”When Calories & Cardio Don’t Cut It”New podcast weblogCopyright 2023 All rights reserved. エクササイズ・フィットネス フィットネス・食生活・栄養 個人的成功 自己啓発 衛生・健康的な生活
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  • Could This Injection Finally Fix Cellulite?

    Could This Injection Finally Fix Cellulite?
    2026/10/17
    Midlife Mayhem: CBL-514, the Injectable That Could Change Cellulite and Stubborn Fat Is an injection, pill or potion coming for everything? This week Joanne looks at CBL-514, an experimental injectable aimed at stubborn fat and cellulite, and shows how to read a breakthrough headline without getting swept away. 🎧 In This Episode Cellulite and stubborn fat are the two things midlife women ask about most. CBL-514 is an experimental injectable developed for both. It isn’t approved anywhere and can’t be bought, but it points to where this whole field is heading, and it makes a great case study in reading the headlines critically. 🔬 What Is CBL-514? Developed by Taiwanese company Calaway BiopharmaceuticalsA small molecule injection (not a peptide)Designed for non-surgical, localized fat reduction and moderate to severe celluliteStill in clinical trials, not approved anywhere 💡 Why It’s Different: Fewer Fat Cells, Not Just Smaller Ones Diet, training and even GLP-1 medications shrink the size of the fat cells you already have, like letting the water out of a balloon. The cell is still there, which is why weight regain is so common.CBL-514 is proposed to induce apoptosis (programmed cell death) in fat cells, so there are fewer fat cells in a targeted area.Think of it as an injectable liposuction.If the fat cell is gone, it can’t refill. 📊 What the Data Shows So Far Early phase 2a study: abdominal fat volume dropped about 25%, roughly 120 ml (about half a cup)Reported cellulite results: roughly 95% of women with moderate to severe cellulite saw significant improvement Reading the Headline: Key Caveats The results come from the company’s own announcement. That doesn’t make them false, but companies share their most flattering numbers.The study was open label. Participants knew what they were being treated with, and in aesthetics, expectation matters. Placebo-controlled data is the goal.120 ml is meaningful, but the real question is what it looks like on a real body in the mirror. 🧪 What’s Next: The Trials Phase 3 trial, “Supreme 01”: randomized, double-blind and placebo-controlled; started September 2026 and currently recruitingA second pivotal trial has been cleared by the FDAResults from both are expected sometime in 2027Trials use MRI to measure fat volume alongside patient-reported scalesAfter that comes regulatory review, so the product is likely a long way off 🧬 Why Cellulite Is So Hard to Treat It isn’t simply too much fat. It’s largely structural.Bands of connective tissue anchor the skin to a deeper layer, and fat pushes up between the bands, creating dimples.That’s why lean, fit women can have cellulite and some heavier women have none.Hormones, genetics and skin thickness all play a role, and it often worsens after 30 and through menopause as skin thins and collagen declines.Past treatments have had mixed results: an injectable called Qwo (collagenase) is no longer sold in the US, and devices can help modestly but need a lot of maintenance. Joanne also trained in Endermologie and says it can help. 💉 The Weight-Loss Medication Angle Many women on weight-loss medications worry about muscle loss and rapid regain after stopping.Calaway presented animal data at the American Diabetes Association meeting in 2026, looking at CBL-514 combined with tirzepatide. The company says it may help reduce weight regain after stopping treatment and improve metabolic health.Human trials of the combination are planned to begin very soon.As Joanne notes, animal studies aren’t small humans, so the human results are the ones to watch. ⚠️ Joanne’s Take If it works, targeting fat cell number could be a real option for stubborn areas that diet and training don’t touch.Long-term safety is the open question. If fat cells are killed off, where does the fat go? Ectopic fat (stored in places like the liver, muscle and brain) is a concern, and there’s potential for misuse.For cellulite, injecting small pockets of fat under the skin looks incredibly promising.It still won’t fix muscle loss. You can never outsource muscle: results will always depend on resistance training and enough protein. 📣 Announcements Membership program coming next year! Joanne is planning a membership with plenty of topics, including this one.5-Amino 1MQ Pure (Joanne’s product) inhibits lipogenesis, the creation of new fat, and is available now on her website. 🔗 Links & Resources Blue Theory Skin: https://www.bluetheoryskin.comJoanne Lee Store: https://www.joanneleestore.comYouTube: https://www.youtube.com/@JoanneLeeCornishMidlife Mayhem Podcast: https://podcast.joannelee.comSubscribe for Updates: https://api.leadconnectorhq.com/widget/form/qyLTSxd4AhdTYsraMcj6
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    17 分
  • MIDLIFE PIVOT - UP OR DOWN, BUT NEVER SIDEWAYS

    MIDLIFE PIVOT - UP OR DOWN, BUT NEVER SIDEWAYS
    2026/10/07
    Midlife Is a Life Pivot: Why I’m Running Mastering Midlife Again in 2026 Mastering Midlife 2026 runs October 26 – November 21 Join Mastering Midlife → www.midlifemonth.com For the first time since March, I’m running a live program again. And honestly, I felt like I needed to. I've spent much of this year working on my products, Blue Theory Skin Care and a few other things I'll tell you about later, but I kept coming back to the same thought: I need to run Mastering Midlife again. Not because we need more information. We have plenty of that. We have too much information. The problem is what we do with it. Midlife Finally Matters — And Now It's Getting Confusing For decades, midlifers were basically forgotten about. Men. Women. It didn't matter. You were either young or old. There wasn't much conversation about what happens in the decades in between. Meanwhile, people were struggling through perimenopause, menopause, andropause, changes in body composition, declining energy, sleep problems, bloating and all the other things that come with this chapter of life. Now? Midlife is trending. Menopause. HRT. TRT. Peptides. Weight-loss medications. Hormones. Everybody has something to say. And that's fantastic because these are conversations we desperately needed to have. But there is a downside. It's becoming incredibly confusing. The information is fascinating. Truly. I could talk about this stuff all day. But there is a LOT of it. And sometimes I think we make things unnecessarily complicated because, frankly, complicated information makes us sound smarter. I know I'm guilty of that too. But when you're the person trying to figure out what you're actually supposed to do, complicated isn't necessarily helpful. The Information Isn't the Problem We're living in the most information-rich period in history. You can get information from: YouTube Podcasts AI Substack Social media Researchers Doctors Influencers Books Courses You can find almost anything you want. But we've been here before. Remember when YouTube first became a thing? Everyone said, We don't need coaches anymore. All the information is free on YouTube. Well... How did that work out? People spent hours, weeks and months watching videos. Some of the information was excellent. Some was terrible. Some was exaggerated. Some wasn't relevant to the individual watching it. But the biggest problem was that none of it was in order. You had all the pieces to the puzzle. But the puzzle was upside down. You could have every single piece you needed sitting right in front of you and still have no idea how to put the thing together. That's what coaching should do. Give you the information you need, including the information you didn't know you needed, and put it in the right order. Which pieces go first? Which are the corner pieces? Which are the straight edges? How do they fit together? And then you actually start building something. The Solutions Are Much Simpler Than the Information This is one of the biggest things I want people to understand about Mastering Midlife. The information can be complex. The solutions don't have to be. In fact, the solutions are often ridiculously simple. That's good news. Because simple things are easier to: Do. Repeat. Track. Be accountable to. Be consistent with. And that's where the results start to compound. People sometimes come into my programs expecting a secret. They're waiting for the magic solution nobody else knows about. And then I explain something and they're like: Oh. I can do that. Exactly. That's the point. You know why you should do it, you know how to do it, and now you actually do it over and over again. That's where the life pivot starts to happen. What's Included in Mastering Midlife 2026? This is a live four-week group program, but you can participate as much—or as little—as you want. There are 10 live Zoom calls, and every call is recorded. Want to turn your camera on, ask questions and participate? Great. Want to quietly observe? That's fine too. But I do want to talk about the group component because connection is something we're losing. We're becoming increasingly dependent on screens and AI and digital communication. And I'm as guilty of that as anyone. But there is something different about being around people who are working toward the same goal. You don't have to be a "group person." I'm not particularly a group person either. I'm an introvert. I'm just not shy. And I've heard that exact same thing from so many people who join my programs: I don't want to be on camera. I don't want to participate in a group. I'm not a group person. And then they finish the program and tell me how much they got from the people around them. You don't have to be highly involved in the group to benefit from the group. My groups are small enough to be intimate, but large enough to be dynamic. And I know everyone in the program. You have access to me. And Guys — This Isn't Just for Women Please come...
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    34 分
  • LEAN MASS IS NOT MUSCLE MASS

    LEAN MASS IS NOT MUSCLE MASS
    2026/09/28

    The scale says “lean mass.” Your strength tells the fuller story.

    If you’re using a GLP-1, moving through menopause, or simply trying to stay strong as you get older, losing weight isn’t the only thing that matters. What you’re losing—and what you’re keeping—matters more.

    In this episode of Midlife Mayhem, I’m connecting three conversations that are usually discussed separately: protein, GLP-1 medications, and HRT.

    We’re talking about why the standard protein RDA may not be enough when your goal is preserving or building muscle, why I recommend around one gram of protein per pound of goal body weight, and what really happens when you dramatically increase protein intake.

    I also break down one of the biggest concerns surrounding GLP-1 medications: muscle loss.

    When a DEXA scan reports a drop in “lean mass,” that doesn't automatically mean you've lost that amount of muscle. Glycogen, water, organs and connective tissue are all included in lean mass—and rapid weight loss can change several of those very quickly.

    That doesn’t mean muscle loss can’t happen. It absolutely can, particularly when calories drop dramatically without enough protein or resistance training. But this isn’t a problem invented by GLP-1 medications.

    And then there’s HRT.

    Hormone replacement therapy can be enormously valuable during menopause and may improve symptoms, sleep, recovery and quality of life. But HRT doesn't replace the muscle-building stimulus of resistance training.

    The hierarchy is simple:

    1. Resistance training provides the signal.

    2. Protein provides the raw material.

    3. Sleep, recovery, stress management—and, for some women, HRT—support the process.

    In this episode, I also explain why your strength may be one of the most useful warning systems you have. If your weight is falling while your strength is holding or improving, that's very different from watching your weight fall while becoming progressively weaker.

    Precision is the antidote to panic.

    We’ll cover:

    • How much protein you may actually need in midlife

    • Why protein isn't the body-fat villain it's often made out to be

    • What “lean mass” on a DEXA scan actually means

    • GLP-1s, rapid weight loss and muscle preservation

    • Why resistance training becomes even more important when appetite is suppressed

    • Where HRT fits into the muscle-building equation

    • Why strength can tell you something the scale cannot

    No pill, powder, injection or prescription does the reps for you.

    Listen to the full episode of Midlife Mayhem with Joanne Lee Cornish.

    Subscribe to my email list

    BLUE THEORY SKIN CARE - The power of GHK CU for mature skin

    5 amino 1mq & SLU PP 332 - saved my body compostion in my 50's
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    41 分
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