Midlife Mayhem

著者： joanne lee cornish
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  • Welcome to Midlife Mayhem, where we embark on an empowering journey through the world of midlife body composition transformation. In this space, we challenge the misconceptions surrounding aging and redefine what’s possible for those navigating the exhilarating terrain of midlife and beyond. Join me as we explore the science, mindset shifts, and practical strategies that can help you sculpt the body of your dreams, proving that age is no barrier to achieving peak vitality and confidence. Whether you’re seeking to shed excess weight, gain lean muscle, or simply feel more vibrant, this podcast is your trusted companion in the pursuit of a healthier, stronger, and more resilient you. Welcome to a new era of limitless possibilities in midlife body transformation. ”Hi I’m Joanne, and I have been coaching body composition for over 30 years. I’ve worked with household names that you know, and I have worked with thousands of people in my group coaching programs. I was a pro bodybuilder in the 90’s with a top 10 physique in the world, but I only knew how to be in shape and out of shape. That frustration led me on a fascinating path of self-study where I found all the answers I could have asked for and more. But I had to dig for the answers, and I have my own ideas on why those answers are not mainstream and why the weight loss industry fails you, but I will save that for a Midlife Mayhem episode. Author of ”When Calories & Cardio Don’t Cut It”New podcast weblog
    Copyright 2023 All rights reserved.
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あらすじ・解説

Welcome to Midlife Mayhem, where we embark on an empowering journey through the world of midlife body composition transformation. In this space, we challenge the misconceptions surrounding aging and redefine what’s possible for those navigating the exhilarating terrain of midlife and beyond. Join me as we explore the science, mindset shifts, and practical strategies that can help you sculpt the body of your dreams, proving that age is no barrier to achieving peak vitality and confidence. Whether you’re seeking to shed excess weight, gain lean muscle, or simply feel more vibrant, this podcast is your trusted companion in the pursuit of a healthier, stronger, and more resilient you. Welcome to a new era of limitless possibilities in midlife body transformation. ”Hi I’m Joanne, and I have been coaching body composition for over 30 years. I’ve worked with household names that you know, and I have worked with thousands of people in my group coaching programs. I was a pro bodybuilder in the 90’s with a top 10 physique in the world, but I only knew how to be in shape and out of shape. That frustration led me on a fascinating path of self-study where I found all the answers I could have asked for and more. But I had to dig for the answers, and I have my own ideas on why those answers are not mainstream and why the weight loss industry fails you, but I will save that for a Midlife Mayhem episode. Author of ”When Calories & Cardio Don’t Cut It”New podcast weblog
Copyright 2023 All rights reserved.
エピソード
  • Can This Molecule Shrink Fat Cells and Save Muscle?"

    Can This Molecule Shrink Fat Cells and Save Muscle?"
    2025/04/08
    Today, I’m diving into a molecule that might just blow your mind: 5-Amino-1MQ (aka 5-Amino-1-Methylquinolinium). 💥 WWW.5AMINO.COM Why am I talking about this? Because we're in a new era of body composition, longevity, muscle preservation… and this molecule is part of a nonconventional, cutting-edge toolbox 🧰 that’s worth exploring. 🧬 What Is 5-Amino-1MQ? It sounds like something from a sci-fi lab—because it kinda is. But don’t let the name scare you. 👉 It’s a small molecule being researched for its effects on: Fat metabolism 🧈 Muscle preservation 💪 NAD+ levels ⚡ Insulin sensitivity 🧃 And even longevity ⏳ 🔍 How It Works: The Science (Simplified) Let’s break it down without causing brain fog: 🧪 It blocks an enzyme called NNMT (Nicotinamide N-Methyltransferase), which becomes more active in your fat cells as they grow. 🔒 NNMT = The Gatekeeper of Fat Cells It makes fat cells hoard energy 😤 Suppresses metabolism 🐌 Reduces NAD+, the molecule linked to cellular energy and longevity 💥 🧯 When you inhibit NNMT using 5-Amino-1MQ: Fat storage decreases ❌🧈 Energy usage goes up ⚡ Muscle is preserved 💪 NAD+ levels rise ⬆️ Lipid profiles improve 📈 Basically: fat cells shrink, muscle stays, and your body acts more like it did in your 20s. 🎯 🐀 But Wait—Is This Just In Rats? Yeah, the main studies are in rodents 🐭… but the mechanisms apply to humans too. ✅ In one study, rats fed a high-fat diet + 5-Amino-1MQ: Lost fat (even with a calorie surplus) 🍕➡️🔥 Had better blood sugar 🚦 Lower cholesterol 🫀 No muscle loss 🚫💀💪 So... eyebrow-raising? Yes. 😲 💡 Why It's Intriguing for Us www.5amino.com We all know as we age: Muscle gets harder to gain 🧱 Fat gets easier to store 🧈 Metabolism slows down 😩 NAD+ levels tank 🧃⬇️ This compound may reverse that trend by helping us: Burn fat more efficiently 🔥 Preserve precious muscle tissue 💎 Improve energy, blood sugar, and overall vitality ⚡ 💪 Muscle Preservation: My Jam You know me—muscle is my thing. Always has been. 🧠 As we age, building muscle becomes incredibly difficult. 🏋️‍♀️ Even in a calorie deficit, 5-Amino-1MQ appears to preserve lean muscle—which is a game-changer. Especially now, when: Weight loss meds are rampant 💉 And people are losing muscle along with fat—which is NOT the goal. ❌ 🧬 Let’s Talk NAD+ You’ve probably heard of NAD+—a molecule vital for: Mitochondrial health (your body’s batteries) 🔋 DNA repair 🧬 Youthful muscle maintenance 💪✨ As we age, NAD+ drops dramatically. But 5-Amino-1MQ helps prevent that by blocking NNMT. So: 🧪 Less NNMT = More NAD+ = More cellular repair = More metabolic youth. 🙋‍♀️ My Personal Experience I first started taking 5-Amino-1MQ years ago. Bought it from Peptide Sciences—$250 a bottle. 💸 I took it for 3 months during a time when: I wasn’t training much Food was off I was constantly traveling ✈️ 👉 And yet... I didn’t gain a single pound. Not one. I usually gain 4–5 lbs from a trip to England or California. So that was wild. 👨‍🔬 Then Kevin Got Curious... So now Kevin’s on it too, and after 4 months—his blood work improved significantly, especially cholesterol. 💥 I now source my own product. Why? Because I didn’t want to keep spending $500/month 😅 But here’s the drama... 😤 The Saga of Sourcing It’s hydrophobic (moisture sensitive), and I had some issues with capsules breaking. That led to switching to special vegan capsules… and then— 🧨 My website broke. Add-to-cart button? Dead. Shipping calculator? Broken. I ended up learning coding 🤯 and fixing it myself. Took days. Spent money. Was this close to quitting. But… ✨ I’m tenacious. And now? It's BACK. Available on my site. 🔗 Available again on TheShrinkShop.com ⚠️ Legal Disclaimer (of course) 🚫 Not FDA-approved. 🧪 Sold only as a research compound. 👀 Make your own decisions, do your own research. 🧠 Why This All Matters Even if you never take this, here’s what it reveals: ✔️ Your body already has systems for burning fat and preserving muscle. ✔️ This compound doesn’t add something foreign—it helps you use your own biology better. ✔️ It's not magic. It's science. And it's one of many tools emerging in the age of true health optimization. 🔎 Want to Learn More? 📺 Watch my YouTube video here 🔍 Visit 5amino.com 💻 Or grab the full Muscle Month Program: MuscleMonth.com 💪 Final Thoughts We're moving into an age where it's not about just eating less and moving more. That still helps—but... ✨ It's about upgrading the code. ✨ It's about knowing what levers to pull. ✨ It's about preserving your power—for life. If this intrigued you, reach out, do the research, and stay curious.
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    43 分
  • SUSTAINED WEIGHT LOSS - THE PROBLEM

    SUSTAINED WEIGHT LOSS - THE PROBLEM
    2025/04/05
    ❌ Why Sustained Weight Loss Without Muscle Is a Total Fail You might’ve lost weight. 🎉 But if you’ve been losing muscle along the way… we need to talk. This episode will be short and sharp (ish) because I cover this A LOT—but today, we’re laser-focused on why sustainable weight loss is hard when you're losing muscle. ⏳ Muscle Loss Happens with Age—That’s a Given But now, thanks to weight loss meds like Ozempic and Mounjaro, it’s happening faster and bigger. The fear-mongering is out there, but the concern is real: Most people on these meds are losing up to 50% muscle with their weight loss. Why? Because they're losing weight without training. And it’s not a drug issue—it’s a muscle issue. This has been happening since the 800-calorie-diet days. The meds just speed it up. 🧠 Let’s Talk Storage Tanks (aka Your Muscles) Muscle = Nutrient Storage. Roughly 75–80% of your carbs are stored in your muscles. 🛑 Lose muscle = lose storage. So where does the energy go? Straight to fat. 🔧 Think of it like this: You own 6 cars and have a 6-car garage = no problem. Now you have 6 cars and a carport = problem. Less muscle = less storage = more fat gain. 🧱 Anabolic Resistance: When Your Muscles Say "No Thanks" If you don’t train your muscles, they go into anabolic resistance. They stop responding to nutrients like a sponge turning into a stone. 🧽 Healthy muscle = sponge: absorbs amino acids, stores nutrients 🪨 Resistant muscle = stone: won’t absorb anything And if you can’t get nutrients into your muscle, it can’t grow, repair, or survive. You’re starving it—even if you’re eating well. 🧬 Hormonal Chaos from Muscle Loss 1. Leptin Drops ⬇️ Leptin tells your brain you’ve got enough energy. Low leptin = brain thinks you’re starving = slows metabolism + increases hunger. 🍕🥱 2. Ghrelin Increases ⬆️ Ghrelin = the hunger hormone. More muscle loss = more ghrelin = more cravings. Chronic dieting? Poor sleep? Ghrelin goes wild. 3. Insulin Becomes Less Efficient Insulin tries to shove nutrients into your muscle. But if your muscle’s a stone? Nada. The pancreas freaks out, pumps more insulin. 🚫 High insulin = fat storage ON, fat burning OFF 4. Testosterone Tanks 🧔⚠️ Not just for men—women need it too. Muscle loss reduces it = less fat burning, more muscle wasting. 5. Growth Hormone Declines ⬇️ Aka the “Fountain of Youth” hormone. Less growth hormone = less overnight fat burning and muscle building. 6. Myokines Disappear Myokines are released when you contract muscle. They reduce inflammation, improve insulin sensitivity, and boost fat oxidation. No training = no myokines = no fat burning 🔥 🔁 The Domino Effect Here’s what you’re left with if you lose muscle: ❌ Less nutrient storage ❌ Anabolic resistance ❌ Hormonal havoc ❌ Slower metabolism ❌ More hunger ❌ Less fat burning ❌ Weaker immune function 📉 And your metabolic rate? That drops too. 🚛 Be a Truck, Not a Prius I use this analogy a lot: You want to be a big diesel truck that burns through fuel. Not a tiny hybrid that sips gas and stores every crumb. Your muscle mass determines your metabolic rate. More muscle = more calories burned doing nothing. Let’s look at some real-life numbers: Sedentary woman: 1400 calories/day Active, muscular woman: 2200–2800 calories/day One of my clients had a resting metabolic rate of 800 😱 That’s starvation level. And sadly, it’s common in chronic dieters. 🎯 So What’s the Fix? You need to train. You need to lift. You need to eat protein. You need to fight for your muscle like your life depends on it—because it kinda does. 💥 That’s why my Muscle Month (aka Muscle Mastery) program exists. Too late to join live right now, but you can get the evergreen version anytime. 📦 60+ pieces of content 📚 You’ll know more than 90% of trainers 💌 Email me: joe@theshrinkshop.com to get on the waitlist for the next live round 💊 If You’re Using GLP-1 Meds… Listen Up I celebrate your success. 👏 I want you to keep it and optimize it. That’s why I’m writing a new program: RX Success ➡️ For those considering meds, taking them, optimizing them, or stepping away from them ➡️ Shorter, sharper, and designed for sustainable results Coming soon. Stay tuned. 💻📆 🧩 Final Thought The real problem? Most people make this journey too complicated and don’t actually understand what’s happening in their bodies. If I have one mission, it’s this: 👉 To eliminate confusion 👉 To turn frustration into inspiration 👉 To make results feel easy, joyful, and totally achievable 📬 Got questions? Just want to say hi? Shoot me an email: jo@theshrinkshop.com You deserve results that last. And I’m here to help you get them.
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    21 分
  • LOOSE SKIN & GHK CU

    LOOSE SKIN & GHK CU
    2025/04/01
    Loose Skin in Midlife? Let’s Talk About the Blue Miracle Molecule 🧬💉 For a video on my I use GHK CU please go to my youtube video HERE Weight loss, body composition, and finally, building the body you’ve always deserved—especially in midlife and beyond. 💪✨ Let’s cut through the noise. We’re told that middle age is the beginning of the end—weight gain, muscle loss, poor health. Like it's all just part of the deal. If that’s your vibe, cool. But if you’re here to defy that narrative and reclaim your best body yet? Then I’m your gal. 🙋‍♀️ And this podcast? It’s your no-nonsense, no-fluff companion. 🎙️🔥 We break down real body composition strategies, dish out practical tips, and expose the trends worth skipping. I don’t sugarcoat (ever), but I do show you what’s not just possible—but probable. 👇 If this fires you up, check the show notes. You’ll find links to 1:1 coaching, my super popular group programs, and the corporate “Educate to Elevate” experience. Let’s kick mediocrity to the curb together. 🧵 Now, let’s get into it: Loose Skin. It’s a hot topic in my Muscle Month coaching group right now. These legends are building muscle, losing fat, and naturally—asking about the dreaded skin sag. Especially the ladies. 🙋‍♀️ As we age, our skin doesn’t snap back the way it used to. So what can we actually do about it? 💧 Yes, hydration. Yes, muscle building. But there’s also this little blue molecule making big waves: GHK-Cu (aka Copper Peptide). 💙 🤔 What the Heck is GHK-Cu? Discovered in 1973 by Dr. Loren Pickart, GHK-Cu (Glycyl-L-Histidyl-L-Lysine-Copper) is a naturally occurring copper-binding peptide. He found that younger people had higher levels of it, and that it seemed to trigger tissue healing, collagen production, and gene repair. 🧬💥 Today, we know it affects over 4,000 human genes linked to: Collagen & elastin production DNA repair Anti-inflammation Skin structure & regeneration 🧖‍♀️ What It Does for Your Skin Aging skin = loss of: Collagen Elastin Hydration Density GHK-Cu combats all that by: ✅ Promoting angiogenesis (more blood vessels = better nutrient delivery) ✅ Boosting collagen & elastin ✅ Reducing inflammation ✅ Improving skin thickness & tightness ✅ Enhancing hydration and glow Fun fact from my own experience? I found myself constantly rubbing the tops of my hands. Why? Because the skin felt silky smooth. And when I showered? The water just slid off like I was covered in lotion. Unreal. 🧴 How to Use GHK-Cu You’ve got three main methods: 1. Topical Creams & Serums 🧴 Easiest and most common. Look for products with 0.05%–0.5% concentration. Apply once or twice daily to clean skin. Exfoliate or microneedle first for deeper penetration. (Even a skin roller helps!) Great option: I use a $30 serum from Amazon. Link in the show notes. 2. Microneedling + GHK-Cu ✨ Use a microneedling device, then apply GHK-Cu serum. Helps push it deeper into the skin layers for faster results. 3. Injectable / Transdermal Delivery 💉 More advanced. Not FDA-approved for injection, so proceed with caution and professional guidance. I use injectable GHK-Cu 3–5x per week and LOVE it. Link to my YouTube video about it is in the show notes (made for my clients, but you’re welcome to it!). 📆 When Will You See Results? 2–4 weeks: More hydration and smoother texture 4–8 weeks: Skin begins to feel firmer 3 months: Visible improvement in elasticity and sagging ✨ Consistency is everything. Pair it with hydration, good sleep, collagen, and smart skincare. ⚠️ Copper Sensitivity? Heads up. Some people (like me!) feel injection site pain initially. I took an antihistamine the next time and had zero issues. Topical? No problems at all. Always patch test first and don’t mix GHK-Cu with retinol or vitamin C (they cancel each other out ❌). 🔄 Cycling GHK-Cu: Many users (me included) follow a cycle like: 3 months on, 1 month off To avoid potential copper overload or zinc imbalance. 🧪 The Science is Legit 📚 A few highlights from research: 1988 study: GHK-Cu outperformed vitamin C and retinoic acid for skin thickness and wrinkle reduction 2009 study: Improved elasticity and reduced sun damage 2015 study: Activated anti-aging and anti-cancer gene pathways Not snake oil. Not hype. Just science doing its thing. 💡 Bonus Tips for Sagging Skin If copper isn’t for you (due to sensitivity or medical reasons), try this combo: Collagen peptides (I love the lemon Vital Proteins flavor 🍋) Hydration: Nothing makes your skin look more aged than dehydration Gentle exfoliation + barrier repair 📣 Final Thoughts Loose skin can be frustrating—especially when you’re putting in the work. But there ARE things you can do. GHK-Cu might just be your new secret weapon. 🔬💥 If you want more info, shoot me an email: 📧 joe@theshrinkshop.com Let me ...
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    21 分

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