Most women only hear about PCOS in their teens or twenties — when cycles are irregular, acne is flaring, weight is piling onto the midsection, and fertility becomes a concern. But here’s the truth:

👉 PCOS does NOT disappear. 👉 Symptoms simply shift. 👉 And midlife can amplify everything that was simmering beneath the surface for decades.

In this episode of Midlife Mayhem, Joanne breaks down the real metabolic story behind PCOS — not the simplified, fertility-focused version most women are handed in their early years.

You’ll learn:

PCOS fundamentally affects insulin, inflammation, and cortisol long before it affects fertility. Those root issues follow women into midlife even when cycle symptoms fade.

Regular cycles and clearer skin don’t mean PCOS is gone. It simply means estrogen and progesterone have shifted, masking reproductive symptoms while worsening metabolic ones.

This is the perfect storm no one talks about. Declining estrogen + progesterone + long-standing insulin resistance = intensified midsection fat gain, inflammation, cravings, fatigue, and higher cardiometabolic risk.

Afternoon crashes, carb cravings, stubborn belly fat, worsening triglycerides, glucose instability, and unexplained inflammation — these aren’t random. They’re PCOS physiology expressing itself in a new hormonal landscape.

When estrogen drops, insulin resistance rises. When muscle declines, metabolic flexibility crashes. And when progesterone disappears, inflammation spikes. Midlife magnifies every mechanism behind PCOS.

With the chaos of cycles behind them, women can finally address PCOS with precision: strength training, protein prioritization, carb timing, gut repair, insulin management, targeted supplementation, GLP-1 support, and HRT where appropriate.

This episode is packed with the depth, physiology, and straight-talk education that midlife women deserve — and rarely receive.

✨ 5-Amino-1MQ — Metabolic, energy & body composition support 👉 www.5amino.com

✨ SLU-PP-332 (“Exercise in a Bottle”) — A next-generation mitochondrial & longevity compound 👉 www.slu332.com

✨ Joanne’s New Website (80% complete — launching soon!) 👉 www.joannelee.com

✨ To connect with Joanne directly: 📩 joanne@joannelee.com

In this episode of Midlife Mayhem, Joanne dives into one of the wildest cultural shifts in modern health and fitness: how we went from terrified of needles to injecting everything in sight — from weight loss medications to peptides, and now, even experimental compounds.

A few years ago, the idea of self-injecting anything was unthinkable. Today? People proudly post their peptide stacks like they’re Michelin-star meals. But somewhere in all this newfound syringe enthusiasm, we’ve lost sight of something important: the delivery system doesn’t determine the result — the mechanism does.

This is a deep, science-backed, myth-busting conversation for anyone curious about:

• Why injectable doesn’t automatically mean superior

• The real reason scientists use injections in research — and why that doesn’t translate to better human results

• How 5-Amino-1MQ and SLU-PP-332 actually work at the cellular level

• The difference between spikes and stability in metabolism and fat oxidation

• How oral delivery can often outperform injections by providing consistent activation instead of biochemical chaos

• Why small, lipophilic molecules like 5-Amino-1MQ and SLU-PP-332 thrive in oral form — and what that means for energy, endurance, and longevity

• The hidden risks of home-mixed injectables (purity, solvents, contamination, degradation)

• Why consistency, not intensity, is what drives results in body composition and performance

Injectables look hardcore. They feel scientific. But for many compounds — especially small molecules designed to work through long-term cellular signaling — oral delivery isn’t a compromise. It’s often the smarter, safer, and more sustainable route.

The body doesn’t care how fast something hits your bloodstream; it cares how well it integrates into your system. And that’s where the hype ends and the science begins.

“Injectables were designed for lab control, not lifestyle performance.”

“Needles spike. Capsules sustain. And for long-term results — stability wins.”

“We’ve glamorized the syringe, but metabolism doesn’t need theater — it needs consistency.”

Explore the science, studies, and benefits behind these two groundbreaking compounds: 👉 www.5amino.com — Learn about 5-Amino-1MQ and how it supports metabolism, energy, and muscle preservation. 👉 www.slu332.com — Discover SLU-PP-332, the endurance molecule known as “exercise in a bottle.”

And for more in-depth discussions on midlife performance, muscle, and metabolism: 🎥 Subscribe to my YouTube channel — @JoanneLeeCornish