🔥 JULY 4TH FLASH DEAL – ENDS MONDAY! Buy 1 bottle of 5-Amino-1MQ and get the 2nd for $100 – that’s a $39 savings! 🧬 Boost fat loss, protect muscle, and optimize your body’s performance. 👉 Use code JULY4 at checkout at www.5amino.com Expires Monday at noon (MST) – don’t miss it!

This episode is bold, necessary, and deeply personal.

We’re diving into the truth about HRT (Hormone Replacement Therapy) and HGH (Human Growth Hormone), what women actually need, and why most of what you're told is incomplete, underdosed, or simply outdated.

👀 If you’ve ever been told “your labs are normal” while feeling exhausted, anxious, and like a stranger in your own body—this episode is for you.

• The real difference between HRT and HGH

• Why most doctors underprescribe (and what to do about it)

• What bloodwork matters—and what it’s NOT telling you

• Why testosterone is essential for women (yes, really)

• What happens when your progesterone disappears

• The risks and rewards of HGH (and how to do it safely)

• Why peptides like CJC, Ipamorelin, and 5-Amino-1MQ might be the smarter option

• Why information alone doesn’t create results—but coaching support does

Tight28 is my LIVE 28-day program to identify food sensitivities without extreme elimination diets.

No gluten, no dairy, no soy, no added sugar—just clean, powerful results.

🚫 No fluff. No detox gimmicks. ✅ Rapid wins, powerful education, and deep coaching support.

⚠️ This live version won’t return until 2027 as I roll out two other programs. 👉 Join here before Sunday – you’ll thank yourself later.

A premium membership that includes: ✅ Full access to all my content ✅ Weekly live coaching calls ✅ A curated community of high-level doers ✅ Access to me

This will not be open to everyone—only to those serious about growth, community, and results. 💌 Interested? Email Joanne Lee Cornish on YouTube

🔬 Learn more about 5-Amino-1MQ: 👉 www.5amino.com 💥 Use code JULY4 to get the second bottle for just $100 through Monday!

🎙️ Midlife Mayhem Show Notes: Zonulin & Leaky Gut — Why You Can’t Not Be Affected

📆 Tight28 starts July 6–August 2! Enjoy your gluten-filled 4th of July… then join us for 28 days of discovery, education, and possibly the biggest physical and mental relief you didn’t know you needed. 👉 Tight28.com

In today’s episode, we’re getting real about zonulin—what it is, what it does, and why it might be quietly wrecking your health (yes, even if you feel “fine”).

Unlike a food sensitivity (which affects some), zonulin affects everyone. It’s not subjective. It’s not up for debate. And it might just be turning your digestive system into a fishnet factory.

• What is zonulin? A protein made in the small intestine that controls your gut’s tight junctions (think: gatekeeper).

• Cheesecloth vs. Fishnet Stockings Analogy A visual breakdown of what a healthy gut lining should be doing… and what happens when zonulin is chronically elevated.

• The Origin Story Discovered by Dr. Alessio Fasano (Italian gastroenterologist), zonulin was the missing link in how gluten triggers immune responses, even in non-celiacs.

• Why It’s a Universal Problem Zonulin loosens your gut lining in everybody, not just those with gluten sensitivity. When that lining opens too wide, stuff gets into your blood that shouldn’t. Your immune system freaks out. Cue: inflammation, fatigue, mood swings, brain fog, skin issues, and more.

• Enter LPS (Lipopolysaccharides) When zonulin opens the gates, LPS—an inflammatory toxin from normal gut bacteria—sneaks in. It’s been linked to insulin resistance, autoimmune conditions, and chronic fatigue.

• Zonulin Triggers

  • Gluten (especially gliadin)

  • Bacterial overgrowth (E. coli, salmonella, SIBO)

  • Toxins & inflammation

• Why the Body Even Makes Zonulin It’s a defense mechanism—but it backfires when activated daily by diet. Occasional gluten = recoverable. Daily gluten = chronic gut permeability.

• Kevin’s Case Study Gluten out, inflammation gone. Kevin lost 15 lbs in 10 days—pure inflammation and water. Not fat. Just normalized gut havoc.

Yes.

• Stool Test (GI Map, Doctor’s Data): Measures zonulin in the gut

• Blood Test (Serum Zonulin): Measures zonulin that’s leaked into the bloodstream—often high in autoimmune or chronically inflamed individuals

• Zonulin ≠ Sensitivity. It’s a biological mechanism. It works the same in everyone.

• Gluten increases zonulin. Period. Doesn’t matter if you “feel fine”—your gut lining is still impacted.

• This is reversible. Remove the irritants, and the results are often shockingly fast.

Join me for Tight28 (July 6–August 2) We dive into:

• Food reactivity

• Histamine & inflammation

• Gut-brain-skin connections

• How to feel actually better—without going full-on monk mode

👉 Tight28.com Let’s clean up your gut without a “cleanse.” Just smart, scientific education with a side of sass. 🎯

If you eat gluten regularly and think you're unaffected—you're not. Zonulin guarantees it. And you can feel better than you do right now.

🎧 Listen. Learn. Question Everything. That’s Midlife Mayhem.

🔗 Tight28.com | Starts July 6 #MidlifeMayhem #Tight28 #GutHealth #Zonulin #FoodSensitivities #BodyComposition #Inflammation #GlutenFacts #LeakyGut #LPS #GlutenFreeCurious #MidlifeStrong