Drs Michael S. Saag and Charles W. Flexner discuss the mechanisms of drug-drug interactions and the promise and limitations of longer-acting HIV therapeutics for both treatment and prevention.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/986504). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

HIV Infection and AIDS https://emedicine.medscape.com/article/211316-overview

Drug Interactions With Antiretroviral Therapy (ART) https://emedicine.medscape.com/article/2039809-overview

Common Drug Interactions With Protease Inhibitors https://emedicine.medscape.com/article/2041624-overview

HIV-Protease Inhibitors https://pubmed.ncbi.nlm.nih.gov/9562584/

The Role of Drug Metabolizing Enzymes in Clearance https://pubmed.ncbi.nlm.nih.gov/24392841/

AIDS Clinical Trials Group https://actgnetwork.org/

Ritonavir https://reference.medscape.com/drug/norvir-ritonavir-342627

The Cytochrome P450 Isoenzyme and Some New Opportunities for the Prediction of Negative Drug Interaction In Vivo https://pubmed.ncbi.nlm.nih.gov/29780235/

Boosting https://clinicalinfo.hiv.gov/en/glossary/boosting

Cytochrome p450 Structure, Function and Clinical Significance: A Review https://pubmed.ncbi.nlm.nih.gov/28124606/

Darunavir https://reference.medscape.com/drug/prezista-darunavir-342647

Atazanavir https://reference.medscape.com/drug/reyataz-atazanavir-342608

Tenofovir Disoproxil Fumarate https://clinicalinfo.hiv.gov/en/drugs/tenofovir-disoproxil-fumarate/patient

The Structure and Mechanism of Drug Transporters https://pubmed.ncbi.nlm.nih.gov/34272696/

Tenofovir Alafenamide (TAF) Clinical Pharmacology https://pubmed.ncbi.nlm.nih.gov/35146360/

Prodrugs for Improved Drug Delivery: Lessons Learned From Recently Developed and Marketed Products https://pubmed.ncbi.nlm.nih.gov/33137942/

Update on Drug-Drug Interaction at Organic Cation Transporters: Mechanisms, Clinical Impact, and Proposal for Advanced In Vitro Testing https://pubmed.ncbi.nlm.nih.gov/33896325/

The Role of Organic Anion Transporting Polypeptides in Drug Absorption, Distribution, Excretion and Drug-Drug Interactions https://pubmed.ncbi.nlm.nih.gov/27783531/

Creatinine Clearance https://pubmed.ncbi.nlm.nih.gov/31334948/

Dolutegravir https://reference.medscape.com/drug/tivicay-tivicay-pd-dolutegravir-999861

Cobicistat https://reference.medscape.com/drug/tybost-cobicistat-999845

Paxlovid https://pubmed.ncbi.nlm.nih.gov/35138785/

Interaction Between Ritonavir and Statins https://pubmed.ncbi.nlm.nih.gov/11959074/

COVID-19 Drug Interactions https://www.covid19-druginteractions.org/checker

Cabotegravir https://reference.medscape.com/drug/vocabria-apretude-cabotegravir-1000364

Lenacapavir https://reference.medscape.com/drug/sunlenca-lenacapavir-4000240

Inhibitors of the HIV-1 Capsid, a Target of Opportunity https://pubmed.ncbi.nlm.nih.gov/29782334/

Flip-Flop Pharmacokinetics--Delivering a Reversal of Disposition: Challenges and Opportunities During Drug Development https://pubmed.ncbi.nlm.nih.gov/21837267/

Polymeric Biomaterials for Medical Implants and Devices https://pubmed.ncbi.nlm.nih.gov/33465850/

Microneedle Arrays Combined With Nanomedicine Approaches for Transdermal Delivery of Therapeutics https://pubmed.ncbi.nlm.nih.gov/33419118/

Preexposure HIV Prophylaxis https://emedicine.medscape.com/article/2054869-overview