Today's episode builds on the discussion of puberty as a sensitive period from the previous episode with Dr. Megan Gunnar. Featuring developmental scientist Dr. Ronald Dahl, this conversation explores early adolescence as a pivotal transition, highlighting the unique vulnerabilities and opportunities for positive growth during this formative window. Dr. Dahl emphasizes the importance of supporting prosocial learning, cultivating positive emotions, and addressing inequities through integrative, interdisciplinary approaches to improve the lives of children and adolescents. Tune in next month for an episode on Superwoman Schema with Dr. Cheryl Woods Giscombé!

Dr. Ronald Dahl is a pediatrician and developmental scientist whose research focuses on early adolescence as a developmental period with unique opportunities for early intervention to support behavioral and emotional health. He is the Director of the Institute of Human Development at the University of California, Berkeley, where he also serves as a Professor in the School of Public Health and the Joint Medical Program. He is also the Founding Director of the Center for the Developing Adolescent. His research is interdisciplinary and bridges between basic developmental research (emphasizing social and affective neuroscience) and the translation of this work into clinical and social policy relevance. He has published extensively on child and adolescent development, sleep disorders, behavioral/emotional health in children, adolescent brain development and on the policy implications of this work. He has been elected as a Fellow of organizations including: Association for Psychological Science, American Academy of Pediatrics, New York Academy of Sciences and American Academy of Sleep Medicine. He is a Founding Editor of the journal Developmental Cognitive Neuroscience and is a Past President of the Society for Research in Child Development. We especially appreciate his focus on integrative developmental science and translating this area of research into clinical and social policy that can improve the lives of children and adolescents.

Topics Discussed:

• Adolescent Development
• Integrative Developmental Science
• Social Transitions
• Fitting In vs. Standing Out
• Self-Other Concept
• Prosociality
• Population Health
• Sleep and Digital Technology
• Youth Involvement/Co-Creation

Papers Mentioned:

• Dahl, R. E., Armstrong-Carter, E., & Van Den Bos, W. (2024). Wanting to matter and learning to care: A neurodevelopmental window of opportunity for (Pro) social learning? Developmental Cognitive Neuroscience, 69, 101430. https://doi.org/10.1016/j.dcn.2024.101430
• Shoib S, Siddiqui MF, Saleem SM, Chandradasa M. Sir Michael Rutter (2022). Pioneer, legend, and father of modern child psychiatry. Ind Psychiatry J. 2022 Jul-Dec;31(2):384-386. doi: 10.4103/ipj.ipj_244_21.
• Schleider, J. L., Zapata, J. P., Rapoport, A., Wescott, A., Ghosh, A., Kaveladze, B., Szkody, E., & Ahuvia, I. L. (2025). Single-Session Interventions for Mental Health Problems and Service Engagement: Umbrella Review of Systematic Reviews and Meta-Analyses. Annual review of clinical psychology, 10.1146/annurev-clinpsy-081423-025033. Advance online publication. https://doi.org/10.1146/annurev-clinpsy-081423-025033
• Sotomayor, I., *Chang, Y., *Szkody, E., Fox, K., & Schleider, J. L. (under review). A digital, minority stress-focused single-session intervention benefits multiply-marginalized sexual minority adolescents. Preprint
• CERES Project (Sleep in Ukranian Teens)

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The Stress Puzzle is hosted by Dr. Ryan L. Brown (https://www.ryanlinnbrown.com/) and supported by the UCSF Stress Measurement Network, an NIH/NIA funded network which aims to better understand the relationship between stress and health by improving the measurement of stress in research studies. Learn more about available resources to support stress research at: www.stressmeasurement.org.

Have burning questions about stress? Email us at stresspuzzlepod@gmail.com and we may feature your question in a future episode!

For today's episode, I had the honor of speaking with Dr. Megan Gunnar, a developmental psychologist who discusses her research on early life adversity and stress biology showing the importance of puberty as a window of biological flexibility. Dr. Gunnar discussed work from earlier in her career that led her to pursue these questions through an interdisciplinary lens. Tune in next month to hear more on the importance of adolescence from Dr. Ronald Dahl.

Dr. Megan Gunnar is a Regents Professor and Distinguished McKnight University Professor at the University of Minnesota. Her doctoral training was in Developmental Psychology at Stanford University. She then completed her post-doctoral fellowship in Psychoneuroendocrinology at Stanford Medical School. Since then, she has built a remarkable career studying how stress biology affects neurobehavioral development and the processes that help children regulate stress hormones. Dr. Gunnar is a fellow of the National Academy of Sciences and has numerous lifetime achievement awards across many societies and disciplines including the Association for Psychological Science and the International Society for Psychoneuroendocrinology. Learn more about Dr. Gunnar's research: https://innovation.umn.edu/gunnar-lab/

Topics Discussed:

• Developmental Psychoneuroendocrinology
• Stress System Calibration and Recalibration
• Stress Reactivity
• Puberty
• Chronic Stress
• HPA Axis
• Early Life Adversity

Papers Mentioned:

• Gunnar, M. R., DePasquale, C. E., Reid, B. M., Donzella, B., & Miller, B. S. (2019). Pubertal stress recalibration reverses the effects of early life stress in postinstitutionalized children. Proceedings of the National Academy of Sciences, 116(48), 23984–23988. https://doi.org/10.1073/pnas.1909699116
• Gunnar, M. R., & Vazquez, D. M. (2001). Low cortisol and a flattening of expected daytime rhythm: Potential indices of risk in human development. Development and Psychopathology, 13(3), 515–538. https://doi.org/10.1017/S0954579401003066
• Engel, M. L., & Gunnar, M. R. (2020). The development of stress reactivity and regulation during human development. International review of neurobiology, 150, 41–76. https://doi.org/10.1016/bs.irn.2019.11.003
• Gunnar, M. R. (2017). Social Buffering of Stress in Development: A Career Perspective. Perspectives on Psychological Science, 12(3), 355–373. https://doi.org/10.1177/1745691616680612

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The Stress Puzzle is hosted by Dr. Ryan L. Brown (https://www.ryanlinnbrown.com/) and supported by the UCSF Stress Measurement Network, an NIH/NIA funded network which aims to better understand the relationship between stress and health by improving the measurement of stress in research studies. Learn more about available resources to support stress research at: www.stressmeasurement.org.

Have burning questions about stress? Email us at stresspuzzlepod@gmail.com and we may feature your question in a future episode!

Can you believe it's almost the end of 2024?! Join me for a conversation with Dr. Aric Prather about stress, sleep, and social experiences at the holidays + what we know about links between those and our susceptibility to infections and severity of illness. We chatted about foundational knowledge drawn from studies where people are experimentally exposed to rhinovirus (aka the common cold) before moving to a conversation about health behaviors through the holidays. We hope this episode encourages you to indulge in social support and lean into the joy of this holiday season!

Dr. Aric Prather is a Professor and Pritzker Family Fund Endowed Chair in Health and Community in the Department of Psychiatry and Behaviroal Sciences at the University of California, San Francisco. He co-directs the UCSF Aging, Metabolism, and Emotions Center, is the Director of the UCSF Center for Health and Community, and Associate Director of the Stress Measurement Network. His research focuses primarily on links between sleep and health, particularly immune health, and his work is regularly featured in the New York TImes, NPR, and the Today Show.

Topics Discussed:

• Psychoneuroimmunology
• Susceptibility to Illness
• Severity of Illness
• Health Behaviors
• Sleep and Health
• Glucocorticoid Resistance
• Common Cold/Rhinovirus
• Social Support
• Resilience and Self-Care

Research Mentioned:

• Cohen S. Keynote Presentation at the Eight International Congress of Behavioral Medicine: the Pittsburgh common cold studies: psychosocial predictors of susceptibility to respiratory infectious illness. Int J Behav Med. 2005;12(3):123-31.
• Prather, AA, Janicki-Deverts, D, Hall, MH, & Cohen, S. Behaviorally Assessed Sleep and Susceptibility to the Common Cold. Sleep. 2015;38(9):1353–1359.
• Cohen S, Janicki-Deverts D, Turner RB, Doyle WJ. Does hugging provide stress-buffering social support? A study of susceptibility to upper respiratory infection and illness. Psychol Sci. 2015 Feb;26(2):135-47.
• Access the Pittsburgh Common Cold Study data for yourself!
• Spiegel K, Rey AE, Cheylus A, Ayling K, Benedict C, Lange T, Prather AA, Taylor DJ, Irwin MR, Van Cauter E. A meta-analysis of the associations between insufficient sleep duration and antibody response to vaccination. Curr Biol. 2023 Mar 13;33(5):998-1005.e2.
• Newman DB, Gordon AM, Prather AA, Berry Mendes W. Examining Daily Associations Among Sleep, Stress, and Blood Pressure Across Adulthood. Ann Behav Med. 2023 May 23;57(6):453-462.

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The Stress Puzzle is hosted by Dr. Ryan L. Brown (https://www.ryanlinnbrown.com/) and
supported by the UCSF Stress Measurement Network, an NIH/NIA funded network which
aims to better understand the relationship between stress and health by improving the
measurement of stress in research studies. Learn more about available resources to support
stress research at: www.stressmeasurement.org.

Have burning questions about stress? Email us at stresspuzzlepod@gmail.com and we may
feature your question in a future episode!

Welcome back to the Stress Puzzle! This is the second of two episodes highlighting winners of the Stress Measurement Network's (SMN) Stress Science Paper Award. Today we'll hear from the lead author of the winning paper in the Human Empirical/Clinical category, Dr. Tené Lewis. We discussed the findings of their paper, which highlights the importance of stress experienced by close loved ones (e.g., family, friends) for African-American women's cardiovascular health. We also chatted about the strength of her team's methodology, how they disseminate the research to women who participated in their study, and the importance of these findings for conversations around self-care, care work (whether formal or informal), and the enormous responsibility that falls to women who end up as the social safety net.

Dr. Tené Lewis is a Professor in the Rollins School of Public Health at Emory University where she studies health psychology and psychosocial epidemiology with an emphasis on cardiovascular health in women. Much of her research investigates the psychological and social factors underlying cardiovascular health disparities for African-American women compared to women of other racial or ethnic groups. Dr. Lewis’ research has been honored by the Health Psychology Division of the American Psychological Association, as well as the recently renamed Society for Biopsychosocial Science and Medicine. Her work has been featured by NPR, Essence Magazine, and the Washington Post.

SMN Stress Science Paper Award Winner (Human Empirical/Clinical):

• Lewis TT, Parker R, Murden R, Spikes T, Erving C, McKinnon II, Van Dyke ME, Booker B, Quyummi A, Vaccarino V, Moore RH. Network stressors, personal stressors, and ambulatory blood pressure in African-American women - Does Superwoman Schema Play a Role? Health Psychol. 2023 Jul;42(7):485-495. doi: 10.1037/hea0001309.

Topics Discussed:

• Network stressors vs. personal stressors
• Cardiovascular risk
• African American women’s health
• Social networks and social support
• Social safety nets
• Ambulatory blood pressure
• Superwoman Schema
• Dissemination
• Self-care
• Ecological validity

Additional Research Mentioned:

• Woods-Giscombé CL, Lobel M, Zimmer C, Wiley Cené C, Corbie-Smith G. Whose stress is making me sick? Network-stress and emotional distress in African-American women. Issues Ment Health Nurs. 2015;36(9):710-7. doi: 10.3109/01612840.2015.1011759. PMID: 26440874; PMCID: PMC7220100.
• Woods-Giscombé CL. Superwoman schema: African American women's views on stress, strength, and health. Qual Health Res. 2010 May;20(5):668-83. doi: 10.1177/1049732310361892. Epub 2010 Feb 12. PMID: 20154298; PMCID: PMC3072704.
• Work of Jasmine Abrams (e.g., Abrams JA, Hill A, Maxwell M. Underneath the Mask of the Strong Black Woman Schema: Disentangling Influences of Strength and Self-Silencing on Depressive Symptoms among U.S. Black Women. Sex Roles. 2019 May;80(9-10):517-526. doi: 10.1007/s11199-018-0956-y)
• Holding it Together: How women became America's safety net by Jessica Calcaro

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The Stress Puzzle is hosted by Dr. Ryan L. Brown (https://www.ryanlinnbrown.com/) and
supported by the UCSF Stress Measurement Network, an NIH/NIA funded network which
aims to better understand the relationship between stress and health by improving the
measurement of stress in research studies. Learn more about available resources to support
stress research at: www.stressmeasurement.org.

Have burning questions about stress? Email us at stresspuzzlepod@gmail.com and we may
feature your question in a future episode!

Welcome back to the Stress Puzzle! This is the first of two episodes highlighting winners of the Stress Measurement Network's (SMN) Stress Science Paper Award. Today we'll hear from the lead author of the winning paper in the Basic Science category, Dr. Natalia Bobba-Alves. We discussed the findings and implications of their paper (particularly around hypermetabolism, chronic stress, and accelerated cellular aging), directions to move the field forward, and how exciting of a moment it is for interdisciplinary stress science.

Dr. Natalia Bobba-Alves is a Postdoctoral Researcher working at the National Institute on Aging where she focuses on how stress signaling affects cellular energetics and aging. She received numerous awards that supported both her undergraduate and master’s degrees in Uruguay, and then was awarded a Fulbright Foreign Grant, which supported her PhD in Nutritional and Metabolic Biology at Columbia University in New York. There she worked with Dr. Martin Picard in the Mitochondrial PsychoBiology Lab to quantify the energetic cost of stress and the impact on cellular aging.

SMN Stress Science Paper Award Winner (Basic Science):

• Bobba-Alves, N., Sturm, G., Lin, J., Ware, S. A., Karan, K. R., Monzel, A. S., Bris, C., Procaccio, V., Lenaers, G., Higgins-Chen, A., Levine, M., Horvath, S., Santhanam, B. S., Kaufman, B. A., Hirano, M., Epel, E., & Picard, M. (2023). Cellular allostatic load is linked to increased energy expenditure and accelerated biological aging. Psychoneuroendocrinology, 155, 106322. https://doi.org/10.1016/j.psyneuen.2023.106322

Topics Discussed:

• Allostasis/Allostatic load/Wear and Tear
• Chronic Stress
• Glucocorticoid signaling
• Cellular energy expenditure
• Mitochondria/mitochondrial psychobiology
• Homeostasis
• Hypermetabolism
• Social stress vs. molecular stress

Additional Research Mentioned:

• Sterling, P., & Eyer, J. (1988). Allostasis: A new paradigm to explain arousal pathology. In S. Fisher & J. Reason (Eds.), Handbook of life stress, cognition and health (pp. 629–649). John Wiley & Sons.
• Stress Puzzle episode with Dr. Michael Marmot
• Stress Puzzle episode with Dr. Jenny Tung
• Bobba-Alves N, Juster RP, Picard M. (2022) The energetic cost of allostasis and allostatic load. Psychoneuroendocrinology, 146:105951. doi: 10.1016/j.psyneuen.2022.105951.

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The Stress Puzzle is hosted by Dr. Ryan L. Brown (https://www.ryanlinnbrown.com/) and
supported by the UCSF Stress Measurement Network, an NIH/NIA funded network which
aims to better understand the relationship between stress and health by improving the
measurement of stress in research studies. Learn more about available resources to support
stress research at: www.stressmeasurement.org.

Have burning questions about stress? Email us at stresspuzzlepod@gmail.com and we may
feature your question in a future episode!

Welcome back to the Stress Puzzle! I had the joy of speaking with Dr. Jenny Tung, an evolutionary anthropologist and geneticist who discusses her intergenerational and experimental research showing how the social environment affects health and lifespan in non-human primates. She shared about her creative methods to experiment with social hierarchies and the special experience of collaborating with the other women who have led the Amboseli Baboon Research Project in Kenya. For more on human hierarchies and health, check out our last episode with Dr. Michael Marmot.

Dr. Jenny Tung is the Director of the Department of Primate Behavior and Evolution at the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany and a Professor of Evolutionary Anthropology and Biology at Duke University. She co-directs the Amboseli Baboon Research Project, which started in 1971 and is one of the longest running primate field sites in the world located in Kenya. Dr. Tung investigates the genetic and genomic consequences of social environments in baboons, rhesus macaques, and other social mammals. She has advanced the science on social determinants of health by adding DNA analyses to the decades of behavioral observations in baboons to advance lifespan understanding of social influences on health. She has also combined these lifespan studies with creative experimental methods that provide greater causal evidence for the impact of the social environment and on health. Dr. Tung was named a MacArthur Fellow in 2019 for the depth and translational importance of her research. Learn more about Dr. Tung's research: http://www.tung-lab.org/

Topics Discussed:

• Social Hierarchies and Health in Non-Human Primates
• Lifespan Studies and Social Relationships
• Plasticity of the Immune System to Changes in Social Environment
• Methodological Challenges and Future Directions
• Intergenerational Effects of Social Environment
• Collaborative Research through the Amboseli Baboon Research Project

Papers Mentioned:

• Tung, J., Archie, E. A., Altmann, J., & Alberts, S. C. (2016). Cumulative early life adversity predicts longevity in wild baboons. Nature communications, 7(1), 11181. https://doi.org/10.1038/ncomms11181
• Zipple, M. N., Archie, E. A., Tung, J., Altmann, J., & Alberts, S. C. (2019). Intergenerational effects of early adversity on survival in wild baboons. Elife, 8, e47433. https://doi.org/10.7554/eLife.47433

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The Stress Puzzle is hosted by Dr. Ryan L. Brown (https://www.ryanlinnbrown.com/) and supported by the UCSF Stress Measurement Network, an NIH/NIA funded network which aims to better understand the relationship between stress and health by improving the measurement of stress in research studies. Learn more about available resources to support stress research at: www.stressmeasurement.org.

Have burning questions about stress? Email us at stresspuzzlepod@gmail.com and we may feature your question in a future episode!

Welcome back to the Stress Puzzle! For this episode, I was joined by Dr. Michael Marmot who is an expert on social status and health. We discussed his seminal work on the Whitehall Studies of British Civil Servants, translating research into policy, and how he remains an "evidence-based optimist" through it all. Tune in next month to hear about complementary research conducted by Dr. Jenny Tung on social status and health in nonhuman primates!

Dr. Michael Marmot is a Professor of Epidemiology at University College London, Director of the UCL Institute of Health Equity, and Past President of the World Medical Association. He has led multiple longitudinal cohort studies that have massively impacted our understanding of how social conditions influence health and aging, including the Whitehall Studies of British Civil Servants and the English Longitudinal Study of Ageing. Professor Marmot has also chaired the Commission on Social Determinants of Health for the World Health Organization and conducted a Strategic Review of Health Inequalities in England to produce evidence-based policy recommendations to support population health. He was recognized as a global health hero at the World Health Assembly in 2019.

Topics Discussed:

• Social determinants of health / health disparities
• Impact of social policy on health equity
• Challenges of policy implementation
• Prevention science

Research Mentioned:

• Fair Society, Health Lives: The Marmot Review: https://www.instituteofhealthequity.org/resources-reports/fair-society-healthy-lives-the-marmot-review/fair-society-healthy-lives-full-report-pdf.pdf
• Whitehall I: Marmot MG, Rose G, Shipley M, Hamilton PJ. Employment grade and coronary heart disease in British civil servants. J Epidemiol Community Health (1978). 1978 Dec;32(4):244-9. doi: 10.1136/jech.32.4.244. PMID: 744814; PMCID: PMC1060958. https://pubmed.ncbi.nlm.nih.gov/744814/
• Whitehall II: Marmot MG, Smith GD, Stansfeld S, Patel C, North F, Head J, White I, Brunner E, Feeney A. Health inequalities among British civil servants: the Whitehall II study. Lancet. 1991 Jun 8;337(8754):1387-93. doi: 10.1016/0140-6736(91)93068-k. PMID: 1674771. https://pubmed.ncbi.nlm.nih.gov/1674771/
• Destitution in the UK: https://www.jrf.org.uk/deep-poverty-and-destitution/destitution-in-the-uk-2023

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The Stress Puzzle is hosted by Dr. Ryan L. Brown (https://www.ryanlinnbrown.com/) and
supported by the UCSF Stress Measurement Network, an NIH/NIA funded network which
aims to better understand the relationship between stress and health by improving the
measurement of stress in research studies. Learn more about available resources to support
stress research at: www.stressmeasurement.org.

Have burning questions about stress? Email us at stresspuzzlepod@gmail.com and we may
feature your question in a future episode!