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  • New Study: How Exercising Muscle Prevents Chronic Inflammation #33

    New Study: How Exercising Muscle Prevents Chronic Inflammation #33
    2024/07/26
    I hope you enjoy my content and find it interesting or informative, if so, please consider supporting the channel by using one of the affiliate links below: * Buy me a Kofi: https://ko-fi.com/mynmnexperiment * Patreon: https://bit.ly/3hhfjl5 * SubscribeStar: https://bit.ly/3psYo23ProHealth 15% Discount Code: MYNMN (https://prohealth.pxf.io/DKveZG) Renue by Science 10% Discount Code: MYNMN (https://renuebyscience.com/?rfsn=5692699.331801&coupon-code=MYNMN) Renue by Science 15% Subscription Service Discount Code: MYNMNSUB DoNotAge 10% Discount Code: MYNMN (https://bit.ly/2VBDgNt) Youth & Earth 15% Discount Code: MYNMN (https://youthandearth.com?sca_ref=3766764.knrWl4O3cB) Please note that the links above are affiliate links, which means that if you use the code, I will receive a small commission, and if you do, may I say many thanks I advance for your support. My Current Anti-Aging Protocol:· 1.5 grams of an NADBooster (https://bit.ly/3c2Fxt8) · 1.5 grams of Trans-resveratrol (Tue, Thu & Sat) (https://bit.ly/3yxeqy2) · 500mg Metformin· 1.5 grams of TMG (https://bit.ly/3oe1Ted) · 5,000 IU (International Units) of vitamin D3 (https://bit.ly/3P32hYH) · 120 mcg (micrograms) of vitamin K2 (Mk 7) (https://bit.ly/3PhkBgn) · 250mg Magnesium (L-Threonate) (https://bit.ly/3O4pZ5o) · 200mg high molecular weight hyaluronic acid (https://bit.ly/3P0Z4c2) · 2,400mg of Fisetin, on the 1st, 2nd & 3rd of each month (https://bit.ly/3P2rSB0) · 2,400mg of Quercetin, on the 1st, 2nd & 3rd of each month (https://bit.ly/3IzulAy)· Quercetin & Fisetin Periodic Dosing (https://bit.ly/3mw1IgN)· 81mg of aspirin (https://bit.ly/3uFjtem) · 800mg SIRT6 Activator (https://bit.ly/3MyfA4J)· 600mg DIM (https://bit.ly/3ZX9NsG)· 800mg GlyNAC (https://shorturl.ac/7b75r)· 5 grams of Creatine (1 month on, 2 months off) DISCLAIMER: The Video Content has been made available for informational and educational purposes only. The video creator does not make any representation or warranties with respect to the accuracy, applicability, fitness, or completeness of the Video Content. The Video Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. The video creator hereby disclaims any and all liability to any party for any direct, indirect, implied, punitive, special, incidental or other consequential damages arising directly or indirectly from any use of the Video Content, which is provided as is, and without warranties.Longevity, Mortality, Longevity study how to live to 100, Live to 100, Human mortality study, Life expectancy, Human Life expectancy, maximum human lifespan, antiaging, Longevity study, lifespan study, what is maximum human lifespan, what is human lifespan, what is Healthspan, Lifespan, Healthspan, longevity diet, longevity secrets, longevity research, longevity exercises, longevity supplements, antiaging tips, antiaging secrets, antiaging podcast, how to live longer.How to live healthy, Live to 100, Human mortality study, Life expectancy, Human Life expectancy, maximum human lifespan, antiaging, Longevity, Mortality, Longevity study, lifespan study, what is maximum human lifespan, what is human lifespan, what is Healthspan, Lifespan, Healthspan, longevity diet, longevity secrets, longevity research, longevity exercises, longevity supplements, antiaging tips, antiaging secrets, antiaging podcast, how to live longer, how to live healthy.FAIR-USE COPYRIGHT DISCLAIMER Copyright Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, commenting, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational, or personal use tips the balance in favor of fair use. Signal To Noise by Scott Buckley https://soundcloud.com/scottbuckleyCreative Commons — Attribution 3.0 Unported — CC BY 3.0Free Download / Stream: https://bit.ly/signal-to-noiseMusic promoted by Audio Library https://youtu.be/of0Ei_T4isc
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    7 分
  • 4 Changes that DOUBLED my Deep Sleep #32

    4 Changes that DOUBLED my Deep Sleep #32
    2023/09/11
    I hope you enjoy my content and find it interesting or informative, if so, please consider supporting the channel by using one of the affiliate links below:  * Buy me a Kofi: https://ko-fi.com/mynmnexperiment  * Patreon: https://bit.ly/3hhfjl5  * SubscribeStar: https://bit.ly/3psYo23 Renue by Science 10% Discount Code: MYNMN (https://renuebyscience.com/?rfsn=5692699.331801&coupon-code=MYNMN) Renue by Science 15% Subscription Service Discount Code: MYNMNSUBYouth & Earth 15% Discount Code: MYNMN (https://youthandearth.com?sca_ref=3766764.knrWl4O3cB)  ProHealth 15% Discount Code: MYNMN (https://www.prohealth.com/) DoNotAge 10% Discount Code: MYNMN (https://bit.ly/2VBDgNt)  Please note that the links above are affiliate links, which means that if you use the code, I will receive a small commission, and if you do, may I say many thanks I advance for your support.  My Current Anti-Aging Protocol:·      1.5 grams of NMN (https://bit.ly/3c2Fxt8) ·      1.5 grams of Trans-resveratrol (Tue, Thu & Sat) (https://bit.ly/3yxeqy2) ·      500mg Metformin·      1.5 grams of TMG (https://bit.ly/3oe1Ted) ·      5,000 IU (International Units) of vitamin D3 (https://bit.ly/3P32hYH) ·      120 mcg (micrograms) of vitamin K2 (Mk 7) (https://bit.ly/3PhkBgn) ·      250mg Magnesium (L-Threonate) (https://bit.ly/3O4pZ5o) ·      200mg high molecular weight hyaluronic acid (https://bit.ly/3P0Z4c2) ·      2,400mg of Fisetin, on the 1st, 2nd & 3rd of each month (https://bit.ly/3P2rSB0) ·      2,400mg of Quercetin, on the 1st, 2nd & 3rd of each month (https://bit.ly/3IzulAy)·      Quercetin & Fisetin Periodic Dosing (https://bit.ly/3mw1IgN)·      81mg of aspirin (https://bit.ly/3uFjtem) ·      800mg SIRT6 Activator (https://bit.ly/3MyfA4J)·      600mg DIM (https://bit.ly/3ZX9NsG)·      800mg GlyNAC (https://shorturl.ac/7b75r) Why is deep sleep such a big deal, as long as you get around 7 hours total sleep a night, shouldn’t that be enough?Deep sleep has an ancient, restorative power to clear waste from the brain, it’s our body’s way of taking out the trash; waste clearance occurs whilst we are awake but is substantially enhanced during deep sleep.This waste potentially includes toxic proteins that may lead to neuro-degenerative diseases such as Alzheimer's disease and Parkinson's. My Sleep Statistics 2019You can see here that my sleep on 29th, 30th and 31st of October 2019 was good as far as overall time is concerned, 7:34, 7:49 and 7:10.But my deep sleep; the most rejuvenating sleep only accounted for 8% and 17% of the overall total.I managed to increase that to over 25% and if some cases over 40%, and now I will tell you how. Fitness TrackerAs part of my NMN Experiment I purchased a fitness tracker to monitor my heart rate, another function of this tracker is a sleep monitor, it records overall sleep, light sleep, deep sleep and minutes awake.Link below to the one I use...I may do a sperate video on it, let me know if you’d like that.I Experimented with different sleep aids, techniques, types of food, when I ate food, alcohol intake etc. Unless there is an unexpected occurrence, I can now pretty much guarantee that I will get 7 to 8 hours of sleep a night, but more importantly that over 20%, (in one case 43%) will be deep, rejuvenating sleep.  SMART LightsWith white, blue and green light being such an issue to our alertness and melatonin levels I stared to research smart light bulbs, bulbs that I could programme to dim and gradually turn red 2 hours before I actually went to bed.When the lights are on after 8pm it reminds me of the Ops Rooms that I would often frequent when I was in the Army…no white light after sundown.I used these in my study, the living room and the bedroom, in conjunction with my blue light blocking glasses (which I will cover later).Link Below to the bulbs that I use, you will need to download an app so you can control them all from your phone.   Blue and Green Light Blocking GlassesI listened to the likes of Dave Asprey who extoled the virtues of Blue and green light blocking eyewear, of which he owns a company,I also watched an interview with the BLUblox CEO, Andy Mant where he further explained the science behind how blue light affects our sleep patterns.The science seemed unquestionable, so I purchased this pair of glasses.Did they work, well when you put them on 2 hours before you sleep, they certainly do make you feel sleepy. However, over a period of a few months I tried wearing them on and off and made sure that all lights were out before I went to bed and only had the red lights on if I had to go to the toilet during the night.They made absolutely no difference to my overall sleep, but more importantly to my deep sleep. This may be different for you, Dave Asprey or Andy Mant, but for me ZERO effect!So, they are now in the cupboard of broken dreams.Eye ...
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    16 分
  • Researchers Identify a NEW Promising Model for Studying Human Aging #31

    Researchers Identify a NEW Promising Model for Studying Human Aging #31
    2023/09/09
    I hope you enjoy my content and find it interesting or informative, if so, please consider supporting the channel by using one of the affiliate links below:  * Buy me a Kofi: https://ko-fi.com/mynmnexperiment  * Patreon: https://bit.ly/3hhfjl5  * SubscribeStar: https://bit.ly/3psYo23Renue by Science 10% Discount Code: MYNMN (https://renuebyscience.com/?rfsn=5692699.331801&coupon-code=MYNMN) Renue by Science 15% Subscription Service Discount Code: MYNMNSUB Youth & Earth 15% Discount Code: MYNMN (https://youthandearth.com?sca_ref=3766764.knrWl4O3cB)  ProHealth 15% Discount Code: MYNMN (https://www.prohealth.com/) DoNotAge 10% Discount Code: MYNMN (https://bit.ly/2VBDgNt)Please note that the links above are affiliate links, which means that if you use the code, I will receive a small commission, and if you do, may I say many thanks I advance for your support.  My Current Anti-Aging Protocol:·      1.5 grams of NMN (https://bit.ly/3c2Fxt8) ·      1.5 grams of Trans-resveratrol (Tue, Thu & Sat) (https://bit.ly/3yxeqy2) ·      500mg Metformin·      1.5 grams of TMG (https://bit.ly/3oe1Ted) ·      5,000 IU (International Units) of vitamin D3 (https://bit.ly/3P32hYH) ·      120 mcg (micrograms) of vitamin K2 (Mk 7) (https://bit.ly/3PhkBgn) ·      250mg Magnesium (L-Threonate) (https://bit.ly/3O4pZ5o) ·      200mg high molecular weight hyaluronic acid (https://bit.ly/3P0Z4c2) ·      2,400mg of Fisetin, on the 1st, 2nd & 3rd of each month (https://bit.ly/3P2rSB0) ·      2,400mg of Quercetin, on the 1st, 2nd & 3rd of each month (https://bit.ly/3IzulAy)·      Quercetin & Fisetin Periodic Dosing (https://bit.ly/3mw1IgN)·      81mg of aspirin (https://bit.ly/3uFjtem) ·      800mg SIRT6 Activator (https://bit.ly/3MyfA4J)·      600mg DIM (https://bit.ly/3ZX9NsG)·      800mg GlyNAC (https://shorturl.ac/7b75r) For adults in their 40s, sarcopenia is hardly noticeable—about 3% muscle mass is lost each decade. However, for those aged 65 years and older, muscle decline can become much more rapid, with an average loss of 1% muscle mass per year.More importantly, sarcopenia is also marked by a decrease in strength, impaired gait, reduced physical activity and difficulty completing simple everyday tasks such walking, sitting down and standing up unaided. The Future The proportion of older adults aged 65+ is projected to more than double by the year 2060, this is driving research into the process of musculoskeletal decline.Researchers at Colorado State University's Columbine Health Systems Center for Healthy Aging believe they have found an animal model that will help them better understand it and find ways to limit the symptoms.The study, published in Frontiers in Physiology: Striated Muscle in October, is an example of using comparative medicine to understand human diseases and conditions.   Animal ModelsScientists often rely on animal models to mimic disease progression and study the prevention, diagnosis and treatment of medical conditions.However, until now, no animal model has been able to fully capture all aspects of human musculoskeletal aging.Karyn Hamilton Karyn Hamilton, a professor in the Colorado State University's Department of Health and Exercise Science, and associate director at the Center for Healthy Aging said "Existing pre-clinical models either rely on unloading the muscle, meaning mimicking bedrest in an animal, or they must wait until the animals get really, really old, and even then they don't really get the same muscle aging phenotype as people do."Dunkin Hartley Guinea PigIn their work, Hamiliton's team found that the Dunkin Hartley guinea pig was a good candidate for a muscle aging model due to the animal's tendency to develop osteoarthritis at a young age.The two conditions, osteoarthritis and sarcopenia, seem to be linked in humans; with advancing age, skeletal muscle dysfunction increases the risk for osteoarthritis, and osteoarthritis increases the risk for further muscle decline.Hamilton’s teamHamilton teamed up with Dr. Kelly Santangelo—an associate professor in the Department of Microbiology, Immunology, and Pathology at CSU, who has been studying primary osteoarthritis in Hartley guinea pigs for many years, also Associate Professor Raoul Reiser, also in Department of Health and Exercise Science, to understand how skeletal muscle changes as osteoarthritis progresses in guinea pigs.The team hypothesized that those muscle changes may mimic human musculoskeletal aging. Classic signsMuscle composition also changes with age: fast-twitch fibers, which are larger and capable of exerting stronger forces, decrease in number, and slow-twitch fibers, which are smaller and less metabolically efficient, tend to increase.Generally, when people "lose muscle mass," it's the large, fast-twitch fibers that are affected, also with decreasing muscle mass tends to come an ...
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    9 分
  • Prostate Tumors Growth Slowed or EVEN REVERSED with Vitamin D Supplements #30

    Prostate Tumors Growth Slowed or EVEN REVERSED with Vitamin D Supplements #30
    2023/09/04
    I hope you enjoy my content and find it interesting or informative, if so, please consider supporting the channel by using one of the affiliate links below:  * Buy me a Kofi: https://ko-fi.com/mynmnexperiment  * Patreon: https://bit.ly/3hhfjl5  * SubscribeStar: https://bit.ly/3psYo23 Renue by Science 10% Discount Code: MYNMN (https://renuebyscience.com/?rfsn=5692699.331801&coupon-code=MYNMN) Renue by Science 15% Subscription Service Discount Code: MYNMNSUBYouth & Earth 15% Discount Code: MYNMN (https://youthandearth.com?sca_ref=3766764.knrWl4O3cB)  ProHealth 15% Discount Code: MYNMN (https://www.prohealth.com/) DoNotAge 10% Discount Code: MYNMN (https://bit.ly/2VBDgNt)My Current Anti-Aging Protocol:·      1.5 grams of NMN (https://bit.ly/3c2Fxt8) ·      1.5 grams of Trans-resveratrol (Tue, Thu & Sat) (https://bit.ly/3yxeqy2) ·      500mg Metformin·      1.5 grams of TMG (https://bit.ly/3oe1Ted) ·      5,000 IU (International Units) of vitamin D3 (https://bit.ly/3P32hYH) ·      120 mcg (micrograms) of vitamin K2 (Mk 7) (https://bit.ly/3PhkBgn) ·      250mg Magnesium (L-Threonate) (https://bit.ly/3O4pZ5o) ·      200mg high molecular weight hyaluronic acid (https://bit.ly/3P0Z4c2) ·      2,400mg of Fisetin, on the 1st, 2nd & 3rd of each month (https://bit.ly/3P2rSB0) ·      2,400mg of Quercetin, on the 1st, 2nd & 3rd of each month (https://bit.ly/3IzulAy)·      Quercetin & Fisetin Periodic Dosing (https://bit.ly/3mw1IgN)·      81mg of aspirin (https://bit.ly/3uFjtem) ·      800mg SIRT6 Activator (https://bit.ly/3MyfA4J)·      600mg DIM (https://bit.ly/3ZX9NsG)·      800mg GlyNAC (https://shorturl.ac/7b75r)Links: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952478/https://pubmed.ncbi.nlm.nih.gov/22508710/https://www.acs.org/content/acs/en/pressroom/newsreleases/2015/march/vitamin-d-may-keep-low-grade-prostate-cancer-from-becoming-aggressive.htmlhttps://journals.lww.com/oncology-times/fulltext/2015/04250/evidence_that_vitamin_d_can_slow_or_reverse.20.aspxhttps://www.healthline.com/health/prostate-cancer/vitamin-d-and-prostate-cancerhttps://www.cancer.northwestern.edu/news/2014/Murphy-Vitamin-D-Deficiency.htmlhttps://www.medscape.com/viewarticle/842012At the 249th National Meeting & Exposition of the American Chemical Society (ACS) it was announced that supplementing with Vitamin D supplements may slow or even reverse the progression of less aggressive, or low-grade, prostate tumors without the need for surgery or radiation.   Gleason Grading System If a tumor is present in a prostate biopsy, the pathologist will grade its aggressiveness on a scale known as the Gleason Grading System.Tumors attracting a score of 7 or above are considered aggressive and are prone to spreading; they will require either surgical removal of the prostate gland or radiation therapy.However, tumors with a score of 6 or less are classed as less aggressive and in some cases may show no symptoms or cause no health problems for the duration of the man's life. Active Surveillance Bruce Hollis, Ph.D., who is at the Medical University of South Carolina, explained that in cases of a low-grade prostate cancer (a score of 6 or below), many urologists do not treat the disease, but instead initiate "active surveillance. The cure, which means surgery or radiation, is probably worse than the disease, so urologists will wait a year and then conduct another biopsy to see where the patient stands." Elective Surgery That said, knowing that they have even low-grade prostate cancer can cause patients and their family’s excessive anxiety, this may prompt some of the men to undergo elective surgery, despite the risk of complications such as infection, urinary incontinence and erectile dysfunction.But a man must wait at least 60 days from the time of his biopsy before he can undergo surgery, this is that any inflammation caused by the biopsy can wane.Vitamin D supplementationBruce Hollis wondered if giving these men vitamin D supplements during the 60-day waiting period would affect their prostate cancer.Previous research had shown that when men with low-grade prostate cancer took vitamin D supplements for a year, 55% of them showed decreased Gleason scores, and in some of the cases the tumors disappeared completely. Clinical Trial In a new randomized, controlled clinical trial, Bruce Hollis’s team was assigned 37 men who were due to undergo elective surgery.There were two groups, one that received 4,000 IU of vitamin D per day and a second placebo group that didn't receive vitamin D.The men's prostate glands were removed and examined 60 days later. ResultsHollis stated, “The new research suggests that vitamin D supplementation may improve low-grade prostate cancers by reducing inflammation, perhaps lessening the need for eventual surgery or radiation treatment.”He went on to say…·"We don't know yet whether ...
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    6 分
  • Why YOU SHOULD combine a Senolytic with your NAD Booster #29

    Why YOU SHOULD combine a Senolytic with your NAD Booster #29
    2023/09/02
    I hope you enjoy my content and find it interesting or informative, if so, please consider supporting the channel by using one of the affiliate links below:  * Buy me a Kofi: https://ko-fi.com/mynmnexperiment  * Patreon: https://bit.ly/3hhfjl5  * SubscribeStar: https://bit.ly/3psYo23Renue by Science 10% Discount Code: MYNMN (https://renuebyscience.com/?rfsn=5692699.331801&coupon-code=MYNMN) Renue by Science 15% Subscription Service Discount Code: MYNMNSUBYouth & Earth 15% Discount Code: MYNMN (https://youthandearth.com?sca_ref=3766764.knrWl4O3cB)  ProHealth 15% Discount Code: MYNMN (https://www.prohealth.com/) DoNotAge 10% Discount Code: MYNMN (https://bit.ly/2VBDgNt) Renue by Science 10% Discount Code: MYNMN (https://renuebyscience.com/?rfsn=5692699.331801&coupon-code=MYNMN) Renue by Science 15% Subscription Service Discount Code: MYNMNSUB My Current Anti-Aging Protocol:·      1.5 grams of NMN (https://bit.ly/3c2Fxt8) ·      1.5 grams of Trans-resveratrol (Tue, Thu & Sat) (https://bit.ly/3yxeqy2) ·      500mg Metformin·      1.5 grams of TMG (https://bit.ly/3oe1Ted) ·      5,000 IU (International Units) of vitamin D3 (https://bit.ly/3P32hYH) ·      120 mcg (micrograms) of vitamin K2 (Mk 7) (https://bit.ly/3PhkBgn) ·      250mg Magnesium (L-Threonate) (https://bit.ly/3O4pZ5o) ·      200mg high molecular weight hyaluronic acid (https://bit.ly/3P0Z4c2) ·      2,400mg of Fisetin, on the 1st, 2nd & 3rd of each month (https://bit.ly/3P2rSB0) ·      2,400mg of Quercetin, on the 1st, 2nd & 3rd of each month (https://bit.ly/3IzulAy)·      Quercetin & Fisetin Periodic Dosing (https://bit.ly/3mw1IgN)·      81mg of aspirin (https://bit.ly/3uFjtem) ·      800mg SIRT6 Activator (https://bit.ly/3MyfA4J)·      600mg DIM (https://bit.ly/3ZX9NsG)·      800mg GlyNAC (https://shorturl.ac/7b75r) Links:https://singularityhub.com/2020/11/24/another-win-for-senolytics-fighting-aging-at-the-cellular-level-just-got-easier/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405395/https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(19)30641-3/fulltexthttps://www.nature.com/articles/s42255-020-00305-3https://www.nature.com/articles/s41591-018-0092-9https://www.nature.com/articles/s41591-018-0092-9https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911708/https://www.nature.com/articles/s41587-020-00750-1https://www.healtheuropa.eu/senolytic-drugs-can-this-antibiotic-treat-symptoms-of-ageing/100585/ Firstly, many thanks to Tao Plakrapong, for sending me a link to this article. This is a review of the article ‘Another Win for Senolytics: Fighting Aging at the Cellular Level Just Got Easier’ by Shelly Fan PhD and some other interesting information on senolytic trials.Links in the description below to the article and the other links I used to make this presentation.  Hallmarks of Aging In the article Shelly references the parable of the blind men and the elephant and likens it to Longevity. For those unfamiliar with the parable, in essence blind men who don’t know what an elephant is are asked to touch a different body part and then conceptualize what the animal is like, because of their limited experience and specific area of touch, each man has vastly different conclusion and they all believe that they’re description is correct. She says that aging, thanks to its complexity, is the bio-medical equivalent of the elephant.In that researchers have focused on either one or another “hallmark” of aging, with some success, but not a number together.Joining the DotsFor example, past research has shown us that energy production in our cells can become erratic and non-functional as we age. Cells programmed for apoptosis don’t die, but instead become zombie-like “senescent cells. A "senescent cell" is a cell in our body whose telomeres have reached their "Hayflick Limit" i.e. its telomeres have become so short that the cell cannot divide anymore.It is not a healthy cell anymore, it’s not exactly dead, but it is programmed for death, this cell death is called apoptosis, the Greek for self-eating, if it doesn’t die it starts to produce chemicals that increase inflammation and damage our DNA.The key is to find out how other hallmarks of aging, such as lower NAD, inflammation and shortening telomeres interact with zombie cells, so we can see the whole picture. The StudyA new study published in Nature Metabolism has starting to connect the dots. A study, in mice, linked-up three promising anti-aging pathways·     Attacking senescent cells·     Addressing inflammation·     Tackling unreliable energy production in cellsAll three elements point to one key factor that drives aging. Healthy to Zombie CellShelly likens individual cells to small cities; each with their own power plants and their ‘superstar’ molecular worker is Nicotinamide Adenine Dinucleotide (NAD). As we know NAD...
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    12 分
  • 27,000 DEATHS a year from this AGE-RELATED DISEASE #28

    27,000 DEATHS a year from this AGE-RELATED DISEASE #28
    2023/08/31
    I hope you enjoy my content and find it interesting or informative, if so, please consider supporting the channel by using one of the affiliate links below:  * Buy me a Kofi: https://ko-fi.com/mynmnexperiment  * Patreon: https://bit.ly/3hhfjl5  * SubscribeStar: https://bit.ly/3psYo23 Renue by Science 10% Discount Code: MYNMN (https://renuebyscience.com/?rfsn=5692699.331801&coupon-code=MYNMN) Renue by Science 15% Subscription Service Discount Code: MYNMNSUBYouth & Earth 15% Discount Code: MYNMN (https://youthandearth.com?sca_ref=3766764.knrWl4O3cB)  ProHealth 15% Discount Code: MYNMN (https://www.prohealth.com/) DoNotAge 10% Discount Code: MYNMN (https://bit.ly/2VBDgNt)My Current Anti-Aging Protocol:·      1.5 grams of NMN (https://bit.ly/3c2Fxt8) ·      1.5 grams of Trans-resveratrol (Tue, Thu & Sat) (https://bit.ly/3yxeqy2) ·      500mg Metformin·      1.5 grams of TMG (https://bit.ly/3oe1Ted) ·      5,000 IU (International Units) of vitamin D3 (https://bit.ly/3P32hYH) ·      120 mcg (micrograms) of vitamin K2 (Mk 7) (https://bit.ly/3PhkBgn) ·      250mg Magnesium (L-Threonate) (https://bit.ly/3O4pZ5o) ·      200mg high molecular weight hyaluronic acid (https://bit.ly/3P0Z4c2) ·      2,400mg of Fisetin, on the 1st, 2nd & 3rd of each month (https://bit.ly/3P2rSB0) ·      2,400mg of Quercetin, on the 1st, 2nd & 3rd of each month (https://bit.ly/3IzulAy)·      Quercetin & Fisetin Periodic Dosing (https://bit.ly/3mw1IgN)·      81mg of aspirin (https://bit.ly/3uFjtem) ·      800mg SIRT6 Activator (https://bit.ly/3MyfA4J)·      600mg DIM (https://bit.ly/3ZX9NsG)·      800mg GlyNAC (https://shorturl.ac/7b75r) Links:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269139/#:~:text=Sarcopenia%20is%20a%20condition%20characterized,exclusively%20seen%20in%20older%20persons.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066461/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623318/https://pubmed.ncbi.nlm.nih.gov/27370407/https://pubmed.ncbi.nlm.nih.gov/27376823/https://pubmed.ncbi.nlm.nih.gov/25365952/https://pubmed.ncbi.nlm.nih.gov/26844538/https://pubmed.ncbi.nlm.nih.gov/25826683/https://pubmed.ncbi.nlm.nih.gov/26073423/https://pubmed.ncbi.nlm.nih.gov/26980367/https://pubmed.ncbi.nlm.nih.gov/26566405/https://www.medicalnewstoday.com/articles/318501https://www.thelancet.com/article/S0140-6736(19)31138-9/fulltexthttps://www.health.harvard.edu/staying-healthy/preserve-your-muscle-masshttps://www.sciencedirect.com/science/article/pii/S1568163716302719https://www.healthline.com/health/sarcopenia#preventionhttps://www.healthline.com/nutrition/sarcopenia#TOC_TITLE_HDR_5https://www.webmd.com/healthy-aging/guide/sarcopenia-with-agingSarcopenia is the loss of muscle mass specifically related to aging. It’s normal to lose some muscle mass as you age. However, sarcopenia describes severe muscle loss that strays from the norm. Sarcopenia affects your gait, your balance and your overall ability to perform daily tasks. For too long, researchers have believed that this deterioration in muscle was inevitable. But they’re now beginning to look into treatments that might prevent or slow down this process.  SymptomsPeople with sarcopenia often experience weakness and lose stamina. This can affect their ability to carry out even the simplest of physical activities like walking or sitting. This reduction in activity then leads to further muscle mass loss and instability. CausesA common cause of sarcopenia is decreased physical activity throughout the day. However, although less frequent, some people with active lifestyles may also be diagnosed with sarcopenia, this suggests that there could be other reasons for the development of the disease. Researchers currently believe that other causes of sarcopenia could include:·     a reduction in the nerve cells that send signals from your brain to tell your muscles to move·     a lowering of your hormone levels·     a decline in your body’s ability to convert protein to energy, remember this is one of the roles of NAD·     not consuming enough daily calories and protein in order to maintain your muscle mass Treatment - ExerciseThe main treatment path for sarcopenia is exercise. Researchers have identified resistance training as the specific form of exercise that is most beneficial to people with sarcopenia. This training is designed to improve muscle strength and stamina and uses resistance bands or weights. Resistance training can also help balance your hormone levels.It has been shown to improve our ability to turn protein into energy. These changes have in some cases been seen in only two weeks. The right intensity and frequency of exercise is vital, so you achieve the best results, without causing injury.So, spending 45 minutes at the gym, but only training for 25 won’t cut it; trust me you’re only kidding yourself . Hormone ...
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    8 分
  • What is Biological Age Testing? #27

    What is Biological Age Testing? #27
    2023/08/30
    I hope you enjoy my content and find it interesting or informative, if so, please consider supporting the channel by using one of the affiliate links below:  * Buy me a Kofi: https://ko-fi.com/mynmnexperiment  * Patreon: https://bit.ly/3hhfjl5  * SubscribeStar: https://bit.ly/3psYo23 Renue by Science 10% Discount Code: MYNMN (https://renuebyscience.com/?rfsn=5692699.331801&coupon-code=MYNMN) Renue by Science 15% Subscription Service Discount Code: MYNMNSUBYouth & Earth 15% Discount Code: MYNMN (https://youthandearth.com?sca_ref=3766764.knrWl4O3cB)  ProHealth 15% Discount Code: MYNMN (https://www.prohealth.com/) DoNotAge 10% Discount Code: MYNMN (https://bit.ly/2VBDgNt) My Current Anti-Aging Protocol:·      1.5 grams of NMN (https://bit.ly/3c2Fxt8) ·      1.5 grams of Trans-resveratrol (Tue, Thu & Sat) (https://bit.ly/3yxeqy2) ·      500mg Metformin·      1.5 grams of TMG (https://bit.ly/3oe1Ted) ·      5,000 IU (International Units) of vitamin D3 (https://bit.ly/3P32hYH) ·      120 mcg (micrograms) of vitamin K2 (Mk 7) (https://bit.ly/3PhkBgn) ·      250mg Magnesium (L-Threonate) (https://bit.ly/3O4pZ5o) ·      200mg high molecular weight hyaluronic acid (https://bit.ly/3P0Z4c2) ·      2,400mg of Fisetin, on the 1st, 2nd & 3rd of each month (https://bit.ly/3P2rSB0) ·      2,400mg of Quercetin, on the 1st, 2nd & 3rd of each month (https://bit.ly/3IzulAy)·      Quercetin & Fisetin Periodic Dosing (https://bit.ly/3mw1IgN)·      81mg of aspirin (https://bit.ly/3uFjtem) ·      800mg SIRT6 Activator (https://bit.ly/3MyfA4J)·      600mg DIM (https://bit.ly/3ZX9NsG)·      800mg GlyNAC (https://shorturl.ac/7b75r) Source 1: https://www.youtube.com/watch?v=Py49yZFk0soSource 2: https://www.youtube.com/watch?v=YqjWQ9CtI-USource 3: http://www.oprah.com/style/twins-and-aging-factors-that-affect-aging/all What is Epigenetics? Epigenetics is the science of how our DNA is controlled and how it’s affected by external factors; these external factors affect our health-span and lifespan. Genetics is fixed from birth; we get our genes from our parents and they define us as being male or female, they control our eye colour, height etc. This is what is measured by companies such as 23andMe.We all share more than 99% of our DNA, however the remaining 1% varies from person to person; this is what makes us unique Epigenetics looks into the dynamic changes in our gene function overtime, changes that don’t involve a change in the underlying DNA sequence; these changes are influenced by external factors  Good to KnowSo, how much can these external ‘epigenetic’ factors actually affect out lifespan and health-span? Someone who is at high risk of heart disease from a genetic predisposition, so there is a family history of heart disease, may have four times the chance of developing heart disease because it is in their genes; that is obviously bad, but compare that to someone who has a low risk of heart disease from a genetic pre-disposition, but is affected by external environmental and lifestyle factors, the risk to them is 5,000 fold, so 5,000 times more chance of getting heart disease because of the environment or the life choices they made.So, there is a lot more risk from factors that are under our control, than from our genes,  As David Sinclair says, ‘Only 20% of longevity is genetic, the rest is up to you, what will you do today?You can Affect thisSo, identical twins have the same DNA, but through lifestyle choices may well have vastly different health outcomes by the time they reach middle-age (Source 3), which twin smoked and didn’t use sunscreen? Biological age testing allows us to read our epigenetic markers, markers that we can influence through changes to our lifestyle. Epigenetic markers change every time one of our cells divides, and even when our cells are not dividing, changes are still taking place to our epigenetic markers. We can affect, through lifestyle, the way that these markers change and through DNA methylation testing we can monitor our progress, either good or bad. It is not easy to do the right thing and there is no magic pill, targeted supplementation is only a small part of the answer.Our Biological Age?So, why should we check our biological age? Our Epigenetic age is a much better measure of our health, well-being, lifespan and health-span than our chronological age.​Knowing our epigenetic or biological age allows ‘us’ - you and me - to move our healthcare needs from being reactive to being proactive;We can become citizen scientists; we can take responsibility for our own longevity by measuring our health objectively at the molecular level And once we know our Epigenetic age, we can take measures to adjust it if necessary, I am guessing no matter what your biological age is, you would like to see it lower?  The Slippery SlopeEpigenetics measures how ...
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    16 分
  • NR Does Not Work in Humans #26

    NR Does Not Work in Humans #26
    2023/08/21
    I hope you enjoy my content and find it interesting or informative, if so, please consider supporting the channel by using one of the affiliate links below:  * Buy me a Kofi: https://ko-fi.com/mynmnexperiment  * Patreon: https://bit.ly/3hhfjl5  * SubscribeStar: https://bit.ly/3psYo23 Renue by Science 10% Discount Code: MYNMN (https://renuebyscience.com/?rfsn=5692699.331801&coupon-code=MYNMN) Renue by Science 15% Subscription Service Discount Code: MYNMNSUBYouth & Earth 15% Discount Code: MYNMN (https://youthandearth.com?sca_ref=3766764.knrWl4O3cB)  ProHealth 15% Discount Code: MYNMN (https://www.prohealth.com/) DoNotAge 10% Discount Code: MYNMN (https://bit.ly/2VBDgNt)My Current Anti-Aging Protocol:·      1.5 grams of NMN (https://bit.ly/3c2Fxt8) ·      1.5 grams of Trans-resveratrol (Tue, Thu & Sat) (https://bit.ly/3yxeqy2) ·      500mg Metformin·      1.5 grams of TMG (https://bit.ly/3oe1Ted) ·      5,000 IU (International Units) of vitamin D3 (https://bit.ly/3P32hYH) ·      120 mcg (micrograms) of vitamin K2 (Mk 7) (https://bit.ly/3PhkBgn) ·      250mg Magnesium (L-Threonate) (https://bit.ly/3O4pZ5o) ·      200mg high molecular weight hyaluronic acid (https://bit.ly/3P0Z4c2) ·      2,400mg of Fisetin, on the 1st, 2nd & 3rd of each month (https://bit.ly/3P2rSB0) ·      2,400mg of Quercetin, on the 1st, 2nd & 3rd of each month (https://bit.ly/3IzulAy)·      Quercetin & Fisetin Periodic Dosing (https://bit.ly/3mw1IgN)·      81mg of aspirin (https://bit.ly/3uFjtem) ·      800mg SIRT6 Activator (https://bit.ly/3MyfA4J)·      600mg DIM (https://bit.ly/3ZX9NsG)·      800mg GlyNAC (https://shorturl.ac/7b75r) Links:https://pubmed.ncbi.nlm.nih.gov/31710095/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509089/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951182/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088772/A long-term clinical study from Denmark has shown that increased Nicotinamide Adenine Dinucleotide (NAD) levels and improved mitochondrial function results from NR supplementation in mice could not unfortunately be repeated in humans. NR 12 Week Study in HumansStudies in animals have shown that NAD boosters stimulate metabolic health by improving mitochondrial function in skeletal muscle, so far NR supplementation has only been shown to raise human NAD levels in blood.Scientists from Denmark have published, in the Journal of Physiology, the results of a 12-week study where they tested the effects of NR on NAD levels and mitochondrial function in human skeletal muscle. Metabolic HealthOur metabolic health depends on mitochondrial function, but as our NAD decreases with age so does our mitochondrial function.Research has linked these declines with age-related diseases such as obesity, insulin resistance and type 2 diabetes, this in turn results in the defective regulation of our skeletal muscle metabolism. Scientific StudyThe team of scientists studied NR supplementation to see if it did in fact increase NAD levels and improve mitochondrial function in human skeletal muscle too.The clinical trial consisted of 40 participants (men with obesity and insulin resistance) They were given 1000 mg NR or a placebo twice a day for 12 weeks, 2000 mg per day is a lot, the advised dose is around 300 mg a day. ResultsThe results showed that NR supplements did not improve NAD levels in the participants’ skeletal muscle.The study also concluded that NR supplementation did not affect the level of mitochondria in their skeletal muscle.The team also measured the levels of citrate synthase, an enzyme that correlates to mitochondrial levels, and unfortunately also found no changes.The team also checked to see if NR supplementation increased reactions that use oxygen to convert nutrients into cellular energy, they found that NR supplementation did not increase in the overall mitochondrial oxidative capacity in human skeletal muscleStudy ConclusionThe team stated, ‘our data does not support the hypothesis that dietary NR supplementation has significant impact on skeletal muscle mitochondria in obese and insulin-resistant men.’ They also stated, ‘Future studies on the effects of NR on human skeletal muscle may include both sexes and potentially provide comparisons between younger and older people.’  The NR communityThe NR community has been very quiet about this study? Charles Brenner who is usually very vocal (in his tweets) when it comes to the lack of NMN human studies or rubbishes anything linked to David Sinclair such as resveratrol, seems to have lost the ability to Tweet.   What the study doesn’t tell usThis study is very specific, if you are a man with obesity and insulin resistance, NR will not improve mitochondrial function in your skeletal muscle, IMHO anyone commenting on this study and not talking about the specifics of this study is just guessing. This study was ...
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    7 分